Alzheimer's disease and miRNA effects (Homo sapiens)

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ER1, 6, 7, 10, 11, 13...4172318183, 2329915, 18, 29128NeuronMicrogliaAICDCalcium overloadp-NFTsDecreased energy production?sAPP-alphaATP depletionAggr. amyloidNeuronal InjuryMitochondrial dysfunctionAICDMitochondiral dysfunctionInsulin resistancealpha-SecretaseC83Cell deathAmyloid Beta (AB)Protein oxidationNOOxidative PhosphorylationAPPHydrogen peroxideCopperIP3MIR101NF-kB MAPTApoptosisInduction of ApoptosisRTN3RAGECalciumAPPBP1TNFRSF1AModulation of gene expressionbeta-amyloid protein 40JAK-STATIronCalcium Signaling Pathway252525APBB1GAPDHADAM10BACE1PSENENPSEN1NCSTNAPH1AIDEMMELPLAPOELRP1FASTNFRSF1AFADDCASP8Cx ICx IICx IIICx IVCx VAPP processingbeta-Secretasegamma-SecretaseHSD17B10Fall in mitochondrialmembrane potentialsAPP-betaC99Increased ROSDegredationInactivationBIDCYCSCALM1CHPBADCALM2CALM3CALML3CALML5PPP3CAPPP3CBPPP3CCPPP3R1PPP3R2CHP2ADAM17PSEN2APAF1CASP9CASP3AB AggregationOligomeric ABalpha-synucleinSNCASenileplaqueNACGPCRGRIN1CACNA1CGRIN2AGRIN2BGRIN2CGRIN2DCACNA1DCACNA1FCACNA1SGNAQPLCB1PLCB2PLCB3PLCB4TNFIL1BMAPK1MAPK3CASP12ApoptosisRYR3PSENENATP2A2ATP2A1ATP2A3EIF2AK3ERN1ATF6ITPR1ITPR2ITPR3CalciumCalciumER stressCAPN1CAPN2TP53CDK5R1NOS1CDK5TAUPGSK3BPCASP3CASP7Paired helical filaments (PHFs)Neurofibrillarytangles (NFTs)ABApoptosisDNA damageInflammationLipid peroxidationONOO-5Based on Table 1 from Burgos et al, PLoS ONE 2014 May.miRNA differentially expressed in AD(measured in cerebrospinal fluid)MIR199BMIR381MIR181B1MIR124-2MIR181DMIR124-1MIR760MIR184MIR136MIR181A1MIR598MIR181A2MIR127MIR34BMIR101-1MIR95MIR488MIR138-2MIR769MIR218-1MIR181B2MIR138-1MIR218-2MIR495MIR708MIR874MIR873MIR129-1MIR129-2MIR139MIR3200MIR431MIR9-1MIR9-2MIR9-3MIR326MIR377MIR433MIR323AMIR134MIR329-1MIR329-2MIR10AMIR33BMIR410MIR708miRNA differentially expressed in AD(measured in blood serum)MIR219-2MIR22MIR125B1MIR1307MIR34CMIR34BMIR887MIR182MIR135A1MIR135A2MIR184MIR127MIR30C2MIR873MIR125AMIR671MIR21MIR1285-2MIR375MIR3176MIR124-3MIR29AMIR29B1MIR29CMIR132MIR34CMIR375MIR124-3MIR9-1MIR138-2MIR138-2MIR132MIR21MIR21MIR21MIR21MIR21MIR1285-2ABP3RTN4HyperinsulinemiaSequestration of IDEConcentrated intoendosome/lysosomeINSINSRIRS1IRS2IRS4PPIDMCUCalciumCalciumCalciumbeta-amyloid protein 42beta-amyloid protein 40beta-amyloid protein 42AKT1AKT2AKT3PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3PIP3


Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

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  5. Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B; ''Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  6. Wasser CR, Herz J; ''Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.''; J Biol Chem, 2017 PubMed Europe PMC Scholia
  7. Lane-Donovan C, Herz J; ''ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.''; Trends Endocrinol Metab, 2017 PubMed Europe PMC Scholia
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  9. Wu H, Huang M, Lu M, Zhu W, Shu Y, Cao P, Liu P; ''Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel.''; Cancer Chemother Pharmacol, 2013 PubMed Europe PMC Scholia
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  32. Small DH, Mok SS, Bornstein JC; ''Alzheimer's disease and Abeta toxicity: from top to bottom.''; Nat Rev Neurosci, 2001 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
128085view01:23, 24 January 2024EweitzFix typo, fix graphically truncated label, standardize case
119468view17:53, 29 June 2021Khanspersadded literature references
119429view23:47, 28 June 2021KhanspersModified title
119428view23:46, 28 June 2021KhanspersModified title
119427view23:43, 28 June 2021Khanspersupdated nonamyloidogenic APP processing
119164view01:14, 19 June 2021Khanspersadded literature references
119163view00:21, 19 June 2021Khanspersadded legend
119162view00:13, 19 June 2021Khanspersadded ptms and updated mutated genes
119161view19:18, 18 June 2021KhanspersUpdated Ab degradation part
119089view05:55, 17 June 2021KhanspersCleaned up the mitochondria part
118932view22:17, 4 June 2021Khansperswork in progress
118931view18:59, 4 June 2021Khanspersreplaced peptide labels with protein nodes
118913view04:38, 4 June 2021KhanspersAdded detail to top left corner
118912view04:15, 4 June 2021Khansperswork in progress
118863view01:01, 3 June 2021KhanspersAdded Wnt signaling
118862view00:29, 3 June 2021Khanspersadded axonal transport defects
118861view00:10, 3 June 2021Khansperswork in progress
118791view23:39, 1 June 2021KhanspersWork in progress
118790view23:12, 1 June 2021Khansperswork in progress
118789view22:28, 1 June 2021KhanspersUpdating with latest information. Work in progress.
118198view05:10, 26 May 2021Khanspersupdate in progress
116396view23:18, 6 May 2021EweitzModified title
115412view11:55, 18 February 2021EgonwMade five more pathways clickable
108233view14:43, 1 December 2019EgonwBetter point to a pathway than a inhibitor metabolite.
108214view11:18, 29 November 2019FehrhartOntology Term : 'DOID:10652' removed !
108091view11:56, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
106706view13:13, 17 September 2019MaintBotHMDB identifier normalization
106521view23:41, 5 September 2019KhanspersModified description
105877view04:50, 16 August 2019KhanspersModified description
105524view05:58, 9 August 2019KhanspersModified description
104977view18:27, 27 June 2019Khanspersremoved KEGG
104976view18:26, 27 June 2019KhanspersModified description
102211view00:06, 11 December 2018Khanspersfixed unconnected interaction
102163view22:07, 4 December 2018Khanspersupdated xrefs for miRNAs
101829view09:35, 12 November 2018EgonwReplaced an old Uniprot data source with the new one.
99069view14:16, 29 October 2018SusanFixed interactions
99043view10:32, 27 October 2018Lovnish.thakurReverted to version '10:25, 27 October 2018' by Lovnish.thakur
99042view10:31, 27 October 2018Lovnish.thakurIncluded RAGE(Receptor for glycosylation end products)interaction with Aβ
99041view10:25, 27 October 2018Lovnish.thakurI have included the Receptor for advanced glycosylation end products(RAGE)in this pathway.Interaction of RAGE with Abeta is also responsible for neuronal damage & inflamation mediated which is mediated by NF-κB & JAK/STAT signaling pathways.
97494view14:02, 23 May 2018Fehrhartfixed connections
97492view13:57, 23 May 2018Fehrhartfixed connections
97491view13:56, 23 May 2018Fehrhartfixed connections
87372view09:56, 22 July 2016MaintBotadded missing graphids
85192view16:05, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
85191view16:01, 23 April 2016EgonwFixed a weird char in a reference.
82906view15:21, 11 November 2015JmeliusCorrect outdated id
79765view02:16, 11 April 2015AlexanderPicoAdded miRNA interactions and refs
79302view19:04, 20 March 2015AlexanderPicoupdated miRNA label
78941view22:47, 16 February 2015KhanspersAdded mir132
78916view21:58, 13 February 2015KhanspersAdded lit ref for mir29

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
APH1AGeneProductENSG00000117362 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
APP processingPathway
APPBP1GeneProductENSG00000159593 (Ensembl)
APPGeneProductENSG00000142192 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ATP2A1GeneProductENSG00000196296 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
ATP2A3GeneProductENSG00000074370 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BACE1GeneProductENSG00000186318 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CACNA1CGeneProductENSG00000151067 (Ensembl)
CACNA1DGeneProductENSG00000157388 (Ensembl)
CACNA1FGeneProductENSG00000102001 (Ensembl)
CACNA1SGeneProductENSG00000081248 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK5R1GeneProductENSG00000176749 (Ensembl)
CHPGeneProduct11261 (Entrez Gene)
CHP2GeneProduct63928 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl)
Calcium Signaling PathwayPathway
CalciumMetaboliteHMDB0000464 (HMDB)
CopperMetaboliteHMDB0000657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DNA damagePathway
EIF2AK3GeneProductENSG00000172071 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GPCRGeneProduct
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HSD17B10GeneProductENSG00000072506 (Ensembl)
Hydrogen peroxideMetaboliteHMDB0003125 (HMDB)
IDEGeneProductENSG00000119912 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
INSGeneProduct3630 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IP3MetaboliteHMDB0001498 (HMDB)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
IRS4GeneProductENSG00000133124 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IronMetaboliteHMDB0000692 (HMDB)
JAK-STATPathwayWP2593 (WikiPathways)
LPLGeneProductENSG00000175445 (Ensembl)
LRP1GeneProductENSG00000123384 (Ensembl)
Lipid peroxidationPathwayWP1878 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPTGeneProductENSG00000186868 (Ensembl)
MCUGeneProductENSG00000156026 (Ensembl)
MIR101-1Rna406893 (Entrez Gene)
MIR101GeneProductENSG00000199135 (Ensembl)
MIR10ARna406902 (Entrez Gene)
MIR124-1Rna406907 (Entrez Gene)
MIR124-2Rna406908 (Entrez Gene)
MIR124-3Rna406909 (Entrez Gene)
MIR125ARna406910 (Entrez Gene)
MIR125B1Rna406911 (Entrez Gene)
MIR127RnaENSG00000207608 (Ensembl)
MIR1285-2Rna100302268 (Entrez Gene)
MIR129-1Rna406917 (Entrez Gene)
MIR129-2RnaENSG00000199077 (Ensembl)
MIR1307Rna100302174 (Entrez Gene)
MIR132GeneProduct406921 (Entrez Gene)
MIR134Rna406924 (Entrez Gene)
MIR135A1Rna406925 (Entrez Gene)
MIR135A2Rna406926 (Entrez Gene)
MIR136RnaENSG00000207942 (Ensembl)
MIR138-1Rna406929 (Entrez Gene)
MIR138-2Rna406930 (Entrez Gene)
MIR138-2RnaENSG00000207649 (Ensembl)
MIR139Rna406931 (Entrez Gene)
MIR181A1Rna406995 (Entrez Gene)
MIR181A2Rna406954 (Entrez Gene)
MIR181B1Rna406955 (Entrez Gene)
MIR181B2Rna406956 (Entrez Gene)
MIR181DRna574457 (Entrez Gene)
MIR182Rna406958 (Entrez Gene)
MIR184Rna406960 (Entrez Gene)
MIR199BRna406978 (Entrez Gene)
MIR21Rna406991 (Entrez Gene)
MIR218-1Rna407000 (Entrez Gene)
MIR218-2Rna407001 (Entrez Gene)
MIR219-2Rna407003 (Entrez Gene)
MIR22RnaENSG00000275595 (Ensembl)
MIR29AGeneProductENSG00000284032 (Ensembl)
MIR29B1GeneProduct407024 (Entrez Gene)
MIR29CGeneProductENSG00000284214 (Ensembl)
MIR30C2RnaENSG00000199094 (Ensembl)
MIR3176Rna100423037 (Entrez Gene)
MIR3200Rna100422912 (Entrez Gene)
MIR323ARnaENSG00000199069 (Ensembl)
MIR326Rna442900 (Entrez Gene)
MIR329-1RnaENSG00000207761 (Ensembl)
MIR329-2Rna574409 (Entrez Gene)
MIR33BRna693120 (Entrez Gene)
MIR34BRnaENSG00000207811 (Ensembl)
MIR34CRna407042 (Entrez Gene)
MIR34CRnaENSG00000207562 (Ensembl)
MIR375RnaENSG00000198973 (Ensembl)
MIR377RnaENSG00000199015 (Ensembl)
MIR381RnaENSG00000199020 (Ensembl)
MIR410RnaENSG00000199092 (Ensembl)
MIR431Rna574038 (Entrez Gene)
MIR433RnaENSG00000207569 (Ensembl)
MIR488RnaENSG00000202609 (Ensembl)
MIR495RnaENSG00000207743 (Ensembl)
MIR598RnaENSG00000207600 (Ensembl)
MIR671Rna768213 (Entrez Gene)
MIR708Rna100126333 (Entrez Gene)
MIR760RnaENSG00000211575 (Ensembl)
MIR769Rna768217 (Entrez Gene)
MIR873RnaENSG00000215939 (Ensembl)
MIR874RnaENSG00000216009 (Ensembl)
MIR887RnaENSG00000216077 (Ensembl)
MIR9-1Rna407046 (Entrez Gene)
MIR9-1RnaENSG00000207933 (Ensembl)
MIR9-2Rna407047 (Entrez Gene)
MIR9-3Rna407051 (Entrez Gene)
MIR95Rna407052 (Entrez Gene)
MMEGeneProductENSG00000196549 (Ensembl)
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NCSTNGeneProductENSG00000162736 (Ensembl)
NF-kB MetaboliteQ27087912 (Wikidata)
NOMetaboliteHMDB0003378 (HMDB)
NOS1GeneProductENSG00000089250 (Ensembl)
ONOO-MetaboliteHMDB0002179 (HMDB)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PIP3MetaboliteHMDB0004249 (HMDB)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PPIDGeneProductENSG00000171497 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
PSEN2GeneProductENSG00000143801 (Ensembl)
PSENENGeneProductENSG00000205155 (Ensembl)
Protein oxidationPathway
RAGEProteinQ15109 (Uniprot-TrEMBL)
RTN3GeneProductENSG00000133318 (Ensembl)
RTN4GeneProductENSG00000115310 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
SNCAGeneProductENSG00000145335 (Ensembl)
TAUGeneProductENSG00000186868 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFRSF1AGeneProductENSG00000067182 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
beta-amyloid protein 40MetaboliteCHEBI:64646 (ChEBI)
beta-amyloid protein 42MetaboliteCHEBI:64647 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2059"
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