TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc) (Homo sapiens)

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Description

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Ontology Terms

Bibliography

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History

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Compare	Revision	Action	Time	User	Comment
	123103	view	08:58, 3 July 2022	Egonw	Made a pathway clickable
	117835	view	15:11, 22 May 2021	Eweitz	Modified title
	107130	view	14:21, 17 September 2019	MaintBot	ChEBI identifier normalization
	105833	view	23:08, 15 August 2019	Khanspers	Modified description
	96056	view	16:30, 15 February 2018	Mkutmon	removed old pathway attributes
	96055	view	16:28, 15 February 2018	Mkutmon	Modified description
	96054	view	16:28, 15 February 2018	Mkutmon	Modified description
	94220	view	22:19, 25 August 2017	DeSl	Added IDs for 3 missing metabolites
	87731	view	09:25, 25 July 2016	MirellaKalafati	Ontology Term : 'pyruvate dehydrogenase complex deficiency pathway' added !
	87724	view	09:20, 25 July 2016	MirellaKalafati	Ontology Term : 'PW:0000002' removed !
	87723	view	09:19, 25 July 2016	MirellaKalafati	Ontology Term : 'disease pathway' added !
	87722	view	09:19, 25 July 2016	MirellaKalafati	Ontology Term : 'citric acid cycle pathway' added !
	87721	view	09:19, 25 July 2016	MirellaKalafati	Ontology Term : 'classic metabolic pathway' added !
	87720	view	09:18, 25 July 2016	MirellaKalafati	Modified title
	87376	view	09:56, 22 July 2016	MaintBot	added missing graphids
	80143	view	17:16, 14 May 2015	Khanspers	updated xrefs
	80142	view	17:11, 14 May 2015	Khanspers	fixed connections, updated annotations
	78495	view	10:28, 7 January 2015	MaintBot	added missing graphIds
	72092	view	21:32, 24 October 2013	Mkutmon	added datasource for "Lipoamide-E"
	71271	view	22:16, 16 October 2013	MaintBot	Automated update of data sources
	69020	view	17:49, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	58689	view	18:30, 19 February 2013	MaintBot	Modified categories
	58688	view	18:29, 19 February 2013	MaintBot	Modified title
	58472	view	20:36, 13 February 2013	Maguirre1	FINAL v1.0
	58471	view	20:31, 13 February 2013	Maguirre1	Periodical save, work in progress
	58470	view	20:20, 13 February 2013	Maguirre1	Periodical save, work in progress
	58469	view	20:10, 13 February 2013	Maguirre1	Periodical save, work in progress
	58468	view	20:00, 13 February 2013	Maguirre1	Periodical save, work in progress
	58467	view	19:50, 13 February 2013	Maguirre1	Periodical save, work in progress
	58466	view	19:40, 13 February 2013	Maguirre1	Periodical save, work in progress
	58465	view	19:30, 13 February 2013	Maguirre1	Periodical save, work in progress
	58464	view	19:20, 13 February 2013	Maguirre1	Periodical save, work in progress
	58463	view	19:10, 13 February 2013	Maguirre1	Periodical save, work in progress
	58461	view	19:00, 13 February 2013	Maguirre1	Periodical save, work in progress
	58460	view	18:49, 13 February 2013	Maguirre1	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
(S)-Malate	Metabolite	C00149 (KEGG Compound)
2-Hydroxy-ethyl- ThPP	Metabolite	C05125 (KEGG Compound)
2-Oxo-glutarate	Metabolite	C00026 (KEGG Compound)
3-carboxy-1- hydroxypropyl-ThPP	Metabolite	440649 (PubChem-compound)
ACLY	GeneProduct	ENSG00000131473 (Ensembl)
ACO1	GeneProduct	ENSG00000122729 (Ensembl)
Acetyl-CoA	Metabolite	C00024 (KEGG Compound)
CS	GeneProduct	ENSG00000062485 (Ensembl)
Citrate	Metabolite	C00158 (KEGG Compound)
DLAT	GeneProduct	ENSG00000150768 (Ensembl)
DLD	GeneProduct	ENSG00000091140 (Ensembl)
DLST	GeneProduct	ENSG00000119689 (Ensembl)
Dihydro- lipoamide-E	Metabolite	80219 (ChEBI)
FH	GeneProduct	ENSG00000091483 (Ensembl)
Fumarate	Metabolite	C00122 (KEGG Compound)
Glycolysis	Pathway	WP534 (WikiPathways)
IDH1	GeneProduct	ENSG00000138413 (Ensembl)
IDH3A	GeneProduct	ENSG00000166411 (Ensembl)
Isocitrate	Metabolite	C00311 (KEGG Compound)
Lipoamide-E	Metabolite	C15972 (KEGG Compound)
MDH1	GeneProduct	ENSG00000014641 (Ensembl)
OGDH	GeneProduct	ENSG00000105953 (Ensembl)
Oxaloacetate	Metabolite	C00036 (KEGG Compound)
Oxalosuccinate	Metabolite	C05379 (KEGG Compound)
PC	GeneProduct	5091 (Entrez Gene)
PCK1	GeneProduct	ENSG00000124253 (Ensembl)
PDHA1	GeneProduct	ENSG00000131828 (Ensembl)
Phosphoenol- pyruvate	Metabolite	C00074 (KEGG Compound)
Pyruvate	Metabolite	C00022 (KEGG Compound)
S-Acetyldihydro- lipoamide-E	Metabolite	C16255 (KEGG Compound)
S-Succinyl- dihydrolipoamide-E	Metabolite	C16254 (KEGG Compound)
SDHA	GeneProduct	ENSG00000073578 (Ensembl)
SUCLG2	GeneProduct	ENSG00000172340 (Ensembl)
Succinate	Metabolite	C00042 (KEGG Compound)
Succinoyl-CoA	Metabolite	C00091 (KEGG Compound)
ThPP	Metabolite	C00068 (KEGG Compound)

Annotated Interactions

No annotated interactions