TGF-beta receptor signaling pathway (Mus musculus)

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DeacetylationNucleusCYProteins in a complex interactionNURecruitmentEnzyme complexAccession Number: NetPath 7; cellmap:7NUNU -> CYCYCYCYDephosphorylationNUGolgi apparatusNUCYReaction through unknown mechanisms/moleculesCYNUNUCYPhosphorylationReceptorCytoplasmMolecular associationCYAutophosphorylationCYCYLigandActivationInhibitionDemethylationERCYNUCYNUNUNUCYProteolytic cleavageEndosomeDNUCYNUNUCYPalmitoylationCYNUNUNUGlycosylationCYNUCYAcetylationDeubiquitinationNUCYTranslocationDesumoylationGlycosylationECCYMitochondriaNUMTNUPlasma membraneGOCYSumoylationNUNU -> CYNUNUCYCYPMCY(Protein-protein interaction)Molecule in the pathwayMethylationExtracellularENEndoplasmic 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 SymbolCdc16E2f4Pias2Xpo1Mapk8Hspa8StrapStrapTgfbr2Cdk6Tgfbr3SkiEngSmad4Cul1Mapk14Rock1Smad4Smad4Smad3Hoxa9Tgfbr2Axin2Tfdp2Sdc2Anapc4NfyaTgfb1Smad7Atf2Smurf2Tgfbr2Snip1Smad7E2f5JunCrebbpSnx6PrkcdPik3r2Anapc5FosbE2f4Smad4Snx2Tgfb1Smad3Smad3E2f5Anapc2Smad6


Description

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Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118015view11:34, 23 May 2021EweitzModified title
111024view14:42, 30 June 2020L DupuisConverted interactions in legend to graphical lines
73847view00:33, 26 February 2014MaintBotupdated schema
71764view20:29, 17 October 2013MaintBotremoved data source from nodes without identifier
67695view11:50, 26 June 2013DdiglesOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
41259view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
34374view22:44, 9 December 2009MaintBotAutomatic update of empty xrefs
28139view21:51, 27 January 2009KhanspersReverted to version '11:31, 14 November 2008' by Khanspers
28138view21:50, 27 January 2009KhanspersChanged name
21221view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:TGF-beta-Receptor NetPath 7]] moved to [[Pathway:WP258]]: Moved to stable identifier
8436view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TGF-beta-Receptor NetPath 7]] moved to [[Pathway:Mus musculus:TGF-beta-Receptor NetPath 7]]: Renaming species
7834view16:21, 18 December 2007MaintBotfixed category names
7305view12:42, 4 November 2007MaintBotAdded categories to GPML
6501view22:19, 22 May 2007A.PandeyReverted to version '14:05, 9 March 2007' by Thomas

External references

DataNodes

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Annotated Interactions

No annotated interactions
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