Nanoparticle-mediated activation of receptor signaling (Homo sapiens)

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1CollagenEGFRAmphiregulinApoptosisHRASFibronectinαIntegrinROSNRASKRASRAFMAP2K1MAP2K2MAPK1JNK1JNK2JNK3MAPK12MAPK13MAPK14MAPK11βTalinPaxillinSrcFAKSosGrbPI3KAKTProliferationInflammationMigrationAngiogenesisDifferentiationReceptor-mediated NP uptakeROSNP-induced extracellular ROS productionEndocytosis of NPAutocrine loop


Description

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Ontology Terms

 

Bibliography

  1. Rauch J, Kolch W, Laurent S, Mahmoudi M; ''Big signals from small particles: regulation of cell signaling pathways by nanoparticles.''; Chem Rev, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123429view06:39, 26 July 2022EgonwTyped six data nodes
110709view14:36, 28 May 2020LaurentAdded missing DataNode type - changed IDs to WikiPathways IDs
106660view21:19, 12 September 2019KhanspersModified description
105661view05:17, 10 August 2019KhanspersModified description
102132view09:12, 2 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
95473view08:43, 16 December 2017EgonwOh, there were two nodes :(
95472view08:42, 16 December 2017EgonwReplace a Wikipedia ID with the matching Wikidata ID (with more mappings).
92317view08:50, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
87898view12:53, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
74251view08:45, 11 April 2014ElisaUsing label type for text elements
74250view08:40, 11 April 2014ElisaUsing label type for text elements
74187view11:00, 3 April 2014Bart SmeetsModified title
74186view11:00, 3 April 2014Bart SmeetsModified description
74185view10:56, 3 April 2014Bart SmeetsModified description
74184view10:55, 3 April 2014Bart SmeetsModified description
74183view10:55, 3 April 2014Bart SmeetsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTProteinQ9Y243 (Uniprot-TrEMBL)
AmphiregulinProteinP15514 (Uniprot-TrEMBL)
AngiogenesisAngiogenesis (Wikipedia)
ApoptosisApoptosis (Wikipedia)
Autocrine loop
CollagenProteinP02452 (Uniprot-TrEMBL)
DifferentiationCellular differentiation (Wikipedia)
EGFRProteinP00533 (Uniprot-TrEMBL)
Endocytosis of NP
FAKProteinQ05397 (Uniprot-TrEMBL)
FibronectinProteinP02751 (Uniprot-TrEMBL)
GrbProteinP62993 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
InflammationInflammation (Wikipedia)
Integrin
JNK1ProteinP45983 (Uniprot-TrEMBL)
JNK2ProteinP45984 (Uniprot-TrEMBL)
JNK3ProteinP53779 (Uniprot-TrEMBL)
KRASProteinP01116 (Uniprot-TrEMBL)
MAP2K1ProteinQ02750 (Uniprot-TrEMBL)
MAP2K2ProteinP36507 (Uniprot-TrEMBL)
MAPK11ProteinQ15759 (Uniprot-TrEMBL)
MAPK12ProteinP53778 (Uniprot-TrEMBL)
MAPK13ProteinO15264 (Uniprot-TrEMBL)
MAPK14 ProteinQ16539 (Uniprot-TrEMBL)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MigrationCell migration (Wikipedia)
NP-induced

extracellular ROS

production
NRASProteinP01111 (Uniprot-TrEMBL)
PI3KProteinO00329 (Uniprot-TrEMBL)
PaxillinProteinP49023 (Uniprot-TrEMBL)
ProliferationCell proliferation (Wikipedia)
RAFProteinP04049 (Uniprot-TrEMBL)
ROSReactive oxygen species (Wikipedia)
Receptor-mediated NP uptake
SosProteinQ07889 (Uniprot-TrEMBL)
SrcProteinP12931 (Uniprot-TrEMBL)
TalinProteinQ9Y490 (Uniprot-TrEMBL)
αProteinP56199 (Uniprot-TrEMBL)
βProteinP05556 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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