PI3K/AKT/mTOR - vitamin D3 signaling (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Ferreira GB, Vanherwegen AS, Eelen G, Gutiérrez AC, Van Lommel L, Marchal K, Verlinden L, Verstuyf A, Nogueira T, Georgiadou M, Schuit F, Eizirik DL, Gysemans C, Carmeliet P, Overbergh L, Mathieu C; ''Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.''; Cell Rep, 2015 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	122432	view	11:35, 5 April 2022	Eweitz	Modified title
	116420	view	09:10, 7 May 2021	Eweitz	Modified title
	106775	view	13:25, 17 September 2019	MaintBot	HMDB identifier normalization
	106551	view	00:12, 6 September 2019	Khanspers	Modified description
	105774	view	19:40, 15 August 2019	Khanspers	Modified description
	98518	view	18:52, 14 September 2018	Khanspers	fixed literature reference
	98517	view	18:50, 14 September 2018	Khanspers	Modified description
	98505	view	12:09, 13 September 2018	Susan	Corrected annotation of the TCA cycle
	98474	view	08:39, 10 September 2018	Susan	Added connections
	96450	view	09:29, 15 March 2018	Egonw	Replaced secondary ChEBI identifiers with primary identifiers.
	95974	view	10:39, 11 February 2018	Egonw	Metabolites don't change to genes (but this needs some redrawing anyway).
	95854	view	17:42, 26 January 2018	Khanspers	Modified description
	95225	view	18:39, 26 November 2017	DeSl	Connected unconnected line.
	95171	view	20:36, 20 November 2017	Susan	Annotated metabolites
	95170	view	20:33, 20 November 2017	Susan	Added annotations and labels
	95147	view	03:29, 17 November 2017	AlexanderPico	fixed interactions
	94303	view	11:18, 1 September 2017	Marvin M2	Changed the unconnected arrows into graphical arrows
	94269	view	12:37, 30 August 2017	Madeomuga
	94266	view	12:14, 30 August 2017	Madeomuga	Ontology Term : 'mTOR signaling pathway' added !
	94265	view	12:14, 30 August 2017	Madeomuga	Ontology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
	94264	view	12:13, 30 August 2017	Madeomuga	Ontology Term : 'vitamin D signaling pathway' added !
	94263	view	12:11, 30 August 2017	Madeomuga
	94262	view	12:01, 30 August 2017	Madeomuga
	94261	view	11:49, 30 August 2017	Madeomuga	Modified description
	94260	view	11:48, 30 August 2017	Madeomuga
	94259	view	09:49, 30 August 2017	Madeomuga	Modified description
	94258	view	09:48, 30 August 2017	Madeomuga	Added literature and description
	94257	view	09:21, 30 August 2017	Madeomuga	Modified title
	94256	view	09:19, 30 August 2017	Madeomuga	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
1,25-(OH)2-D3	Metabolite	CHEBI:17823 (ChEBI)
AKT	GeneProduct	ENSG00000142208 (Ensembl)
AMP/ATP ratio	Metabolite
AMPK	GeneProduct	ENSG00000162409 (Ensembl)
ATP	Metabolite
C-MYC	GeneProduct	ENSG00000136997 (Ensembl)
CD80	GeneProduct	ENSG00000121594 (Ensembl)
CD86	GeneProduct	ENSG00000114013 (Ensembl)
CYP24A1	GeneProduct	ENSG00000019186 (Ensembl)
Cell cycle	Pathway	WP179 (WikiPathways)
Complex formation
Fructose Bisphosphate	Metabolite	CHEBI:65056 (ChEBI)
Fructose-6-P	Metabolite	CHEBI:42378 (ChEBI)
GLUT3	GeneProduct	ENSG00000059804 (Ensembl)
GSK-3b	GeneProduct	ENSG00000082701 (Ensembl)
Glucose-6-P	Metabolite	CHEBI:4170 (ChEBI)
Glycolytic enzymes	Protein
HK3	GeneProduct	ENSG00000160883 (Ensembl)
HLA-DRA	GeneProduct	ENSG00000204287 (Ensembl)
IL-10	Metabolite
IL-12	Metabolite
LDHA	GeneProduct	ENSG00000134333 (Ensembl)
Lactate	Metabolite	CHEBI:24996 (ChEBI)
MMP	Metabolite
PDHA1	GeneProduct	ENSG00000131828 (Ensembl)
PFKFB4	GeneProduct	ENSG00000114268 (Ensembl)
PI3K	GeneProduct	ENSG00000121879 (Ensembl)
Pyruvate	Metabolite	CHEBI:15361 (ChEBI)
ROS	Metabolite
RXR	GeneProduct	ENSG00000186350 (Ensembl)
TCA Cycle	Pathway	WP999 (WikiPathways)
TSC1	GeneProduct	ENSG00000165699 (Ensembl)
TSC2	GeneProduct	ENSG00000103197 (Ensembl)
VDR	GeneProduct	ENSG00000111424 (Ensembl)
mTOR	GeneProduct	ENSG00000198793 (Ensembl)
p65 translocation	Metabolite

Annotated Interactions

No annotated interactions