Acute viral myocarditis (Homo sapiens)

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Revision as of 20:59, 10 June 2018 by Olivier.traets (Talk | contribs)
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31137106, 15, 165, 24CAR/DAF complexDegenerationDegradationIncreased expr.Dystrophin deficiency leads to loss of the sarcoglycan complexpre-cursor to DCMPrimary profibrotic cytokineExtracellular MatrixApoptosis typ I & IIAdjacent CardiomyocytesHIV triggered immunemediated myocarditisPhosphorylated dimersmove to nucleusstimulate gene expression646beta catenin pathwayB CellViral genomic RNA21Max. release ofprogeny virionMyocyte NecrosisFibrosisMyocyte atrophieType 1 induced apoptosisOverproduction of fibrofatty tissue in myocardiumDNA FragmentationCD8*T cellViral replication, inactivation of p21ras10CVB 1 3 5 can all bind to both CAR and DAFViral progeny releaseNucleusCosackie virusUbiquitin-Proteasome SystemMatrix degradation22SarcoplasmHIV-137AutoreactiveantiboediesHost protein synthesis shutoffinduction of CPE1, 12Apoptotic cardiomyocyteERSarcolemmaEnterovirus-induced Cardiomyopathy6Type II induced apoptosisVirus-specific antibodiesMyocyte dysfunctionDystrophinDecreased force transmissionIncreased cell permeabilitySarcoglycan complexAdeno Viruscell cycle arrestCellular activationSuppresses cytopathic effectsLoss of mechanicalstability of the cell26chaoticApoptosis and/or necrosisMyosinActin ReorganizationViral replicationDNA fragmentationwithin nucleusmitochondrionCD4*T Cellantigen presenting cellCalcium pumpMyocyteInflammationAD2 and 5 solely bind the CARHIV-2T cell receptorsignalling pathwayImmune-mediatedmyocyte damage36t-Bid24Symptomatic arrhythmiasECM-receptor interactionTGFB1IL-6Endothelin-1IL-10JAK1STAT3SOCS1EIF4G2IFNGSTAT174CASP8ACTBprostaglandin E210SarcomereBAX28ATF-2SGCBILKCD473C^PROFYNMMP9DAFRAC2ABL1Bcl-xL28RAF-1CASP2MK2CVB133pro-IL-1betaCASP6Tyrosine KinaseCASP7NOD238CCR5TLR3CYCS22, 24MEK 1/2PTCRAp53TNF-alphaBH3 Bid24peptidoglycan muramyl dipeptide39Catenin beta-1IgGHerbimycin Aglycophosphatidylinositol17, 22antigenPro-IL-18IL-1CHRAC1MKK 3/6Ca2+AIF130CCND1JNK122TICAM1SOS1MAPK1RASA110SRC11, 32SGCATNFRSM5DFFB-45GSK3BAKT1AD2MHCIIMHC-1CD55CVB38, 9, 18, 35CARCXADRViral entryCVB320, 28T cell receptor alpha chain V regionSGCDHLA-DMAFormation ofcaveosomesfor CVB3 uptakeENDOG22, 25TLR4IL1Adaptor protein ASCDFFA/ICADhsp27c-JunPerforin-1PIK322Cd28HIVITGALLAMA2CREB12, 23CXCR4ITGB2mature secreted forms29NFkB22CASP314, 34matrix metalloproteinasesIL-12KRT827MYH6IL-2RAC3cardiac antigensDMD135 S A-particleBcl-228DAP5282A^PRODAG1-BTLR5T-cell receptor beta chain V regionstriated muscle contractionNLRP3CASP9MKK 4/7CCR3DystrophinDAG1-aMacrophage7viral antigensEIF4G112, 28SGCGCD40LGBNIP2PARMyocarditisABL2reactive oxygen species generatorsNF-kBERK 1/2CD80CAV1IgGcd86glycophosphatidylinositol17BH3 Bid24, 28Ca2+NucleusantigenPTCRADecreased expr.Increased expr.? Promotes tissue fibrosis ?CAAP1PARP122PABPC1Proteasome


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
128817view22:15, 22 February 2024EweitzOntology Term : 'CD4-positive, alpha-beta T cell' added !
128816view22:14, 22 February 2024EweitzOntology Term : 'CD8-positive, alpha-beta T cell' added !
128815view22:13, 22 February 2024EweitzOntology Term : 'professional antigen presenting cell' added !
128814view22:13, 22 February 2024EweitzOntology Term : 'B cell' added !
123508view05:00, 29 July 2022EgonwMade a pathway clickable
121698view03:38, 26 February 2022EweitzFix gene symbol
120527view02:02, 11 December 2021EweitzModified description
120524view00:19, 11 December 2021EweitzRefine graphics and labels
119226view18:37, 22 June 2021Finterlyadded PMID and DOI
116591view16:29, 8 May 2021EweitzModified title
110705view14:12, 28 May 2020Fehrhartadded label instead of node for mature secreted forms
110701view14:09, 28 May 2020Fehrhartreplaced antigen nodes with labels
110696view13:58, 28 May 2020Fehrhartupdated virus labels
110235view14:00, 29 April 2020EgonwNot a mim-conversion
109212view15:10, 27 February 2020FehrhartILK identifier
109211view15:01, 27 February 2020Fehrhartadeno virus particle
109209view14:34, 27 February 2020Marvin M2Converted line to graphical line
107305view14:37, 19 September 2019EgonwRemove an empty ChEBI identifier
107166view14:25, 17 September 2019MaintBotChEBI identifier normalization
106151view12:04, 16 August 2019MaintBotHMDB identifier normalization
98082view18:38, 17 July 2018Khanspersone more author name
98081view18:36, 17 July 2018Khanspersremoved empty comment field
98080view18:31, 17 July 2018Khanspersone more author name
98079view18:30, 17 July 2018Khanspersfixing faulty rendering of author names
98072view15:15, 16 July 2018Fehrhartadded some annotations
98071view14:37, 16 July 2018FehrhartModified description
97885view18:39, 17 June 2018Olivier.traetsupdated mim-interactions
97880view10:01, 14 June 2018Olivier.traetsUpdated cascade annotations
97878view09:19, 13 June 2018Olivier.traetsModified description
97845view20:59, 10 June 2018Olivier.traetsupdated secondary to primary identifier
97844view19:52, 10 June 2018Olivier.traetsUpdated cascade anotations
97843view19:39, 10 June 2018Olivier.traetsUpdated anotation
97842view19:33, 10 June 2018Olivier.traetsChanged a secundary to a primary identifier
97716view09:23, 7 June 2018Olivier.traetsAdditional data nodes
97711view21:25, 6 June 2018Olivier.traetsAdded complementary proteins
97708view13:56, 6 June 2018Olivier.traetsVisual update
97707view12:02, 6 June 2018Olivier.traetsVisual changes
97706view11:56, 6 June 2018Olivier.traetsVisual changes
97696view09:17, 3 June 2018EgonwModified title
97685view15:05, 1 June 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97615view11:45, 30 May 2018FehrhartOntology Term : 'viral infectious disease' added !
97614view11:44, 30 May 2018FehrhartOntology Term : 'cardiac muscle cell' added !
97613view11:43, 30 May 2018FehrhartOntology Term : 'myocarditis' added !
97612view11:43, 30 May 2018FehrhartOntology Term : 'myocarditis pathway' added !
97611view11:42, 30 May 2018FehrhartOntology Term : 'cardiomyopathy pathway' added !
97610view11:41, 30 May 2018FehrhartOntology Term : 'disease pathway' added !
97597view15:56, 28 May 2018Olivier.traetsModified title
97596view15:56, 28 May 2018Olivier.traetsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
135 S A-particleRna
2A^PROGeneProductMulders MN, Lipskaya GY, van der Avoort HG, Koopmans MP, Kew OM, van Loon AM.

Molecular epidemiology of wild poliovirus type 1 in Europe, the Middle East, and the Indian subcontinent. J Infect Dis 1995;171:1399-1405. 34. Mulders MN, Salminen M, Kalkkinen N, Hovi T. Molecular epidemiology of coxsackievirus B4 and disclosure of the correct VP1/2A(pro) cleavage site: evidence for high genomic diversity and long-term endemicity of distinct genotypes. J Gen Virol 2000;81 Part 3:803-812. 35. Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM. Geographic distribution of wild poliovirus

type 1 genotypes. Virology 1987;160:311-322.
3C^PROGeneProduct
ABL1GeneProductENSG00000097007 (Ensembl)
ABL2GeneProductENSG00000143322 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
AD2
  • subgroups: A, C, D, E & F
  • Type your comment here
AIF1GeneProductENSG00000204472 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
ATF-2ProteinP16951 (Uniprot-TrEMBL)
Adaptor protein ASCProtein
BAXGeneProductENSG00000087088 (Ensembl)
BH3 BidProteinA8ASI8 (Uniprot-TrEMBL)
BNIP2GeneProductENSG00000140299 (Ensembl)
Bcl-2 Protein
Bcl-xLProtein
CAAP1GeneProductENSG00000120159 (Ensembl)
CAR CXADRProteinENSG00000154639.18 (Ensembl)
CASP2GeneProductENSG00000106144 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP6GeneProductENSG00000138794 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8ProteinENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CAV1GeneProductENSG00000105974 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCR3GeneProductENSG00000183625 (Ensembl)
CCR5GeneProductENSG00000160791 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CD4GeneProductENSG00000010610 (Ensembl)
CD55GeneProductENSG00000196352 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CHRAC1GeneProductENSG00000104472 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CVB1
CVB3
  • Enterovirus B
  • https://www.ncbi.nlm.nih.gov/Structure/pdb/1JEW
  • Type your comment here
CXCR4GeneProductENSG00000121966 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Ca2+MetaboliteHMDB00464 (HMDB)
Catenin beta-1ProteinE9PW26 (Uniprot-TrEMBL)
Cd28GeneProduct12487 (Entrez Gene)
DAFProteinA0A1U8D6D6 (Uniprot-SwissProt) Dispensible for productive replication
DAG1-BGeneProduct1605 (Entrez Gene)
DAG1-aGeneProductENSG00000173402 (Ensembl)
DAP5GeneProductENSG00000110321 (Ensembl)
DFFA/ICADGeneProductENSG00000160049 (Ensembl)
DFFB-45 GeneProductENSG00000169598 (Ensembl)
DMDGeneProductENSG00000198947 (Ensembl)
DystrophinProteinA2A9Z1 (Uniprot-TrEMBL)
ECM-receptor interactionPathwayhsa04512 (KEGG Pathway)
EIF4G1GeneProductENSG00000114867 (Ensembl)
EIF4G2GeneProductENSG00000110321 (Ensembl)
ENDOGGeneProductENSG00000167136 (Ensembl)
ERK 1/2Protein
Endothelin-1ProteinP05305 (Uniprot-TrEMBL)
FYNGeneProductENSG00000010810 (Ensembl)
Formation of

caveosomes

for CVB3 uptake
  • Coyne and Bergelson (2006).
  • Type your comment here
GSK3BGeneProductENSG00000082701 (Ensembl)
HIV
HLA-DMAGeneProductENSG00000204257 (Ensembl)
Herbimycin AMetaboliteCHEBI:5674 (ChEBI)
IFNGGeneProductENSG00000111537 (Ensembl)
IL-1GeneProduct
IL-10Protein
IL-12GeneProduct
IL-2ProteinP60568 (Uniprot-TrEMBL)
IL-6 Protein
IL1ProteinG3V169 (Uniprot-TrEMBL)
ILKProtein
ITGALGeneProductENSG00000005844 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
IgGGeneProduct
JAK1GeneProductENSG00000162434 (Ensembl)
JNK1 ProteinA0A087WVY6 (Uniprot-TrEMBL)
KRT8GeneProductENSG00000170421 (Ensembl)
LAMA2GeneProductENSG00000196569 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MEK 1/2Protein
MHC-1 ProteinA0A024RCL3 (Uniprot-TrEMBL)
MHCII Protein
MK2Protein
MKK 3/6Protein
MKK 4/7Protein
MMP9GeneProductENSG00000100985 (Ensembl)
MYH6GeneProductENSG00000197616 (Ensembl)
Macrophage GeneProduct
Myocarditis Pathwaymap05416 (KEGG Pathway)
NF-kBGeneProduct
NFkBGeneProductENSG00000077150 (Ensembl)
NLRP3GeneProduct
NOD2ProteinE9PLF7 (Uniprot-TrEMBL)
PABPC1GeneProductENSG00000070756 (Ensembl)
PARMetabolite
PARP1GeneProductENSG00000143799 (Ensembl)
PIK3GeneProductENSG00000145675 (Ensembl)
PTCRAGeneProductENSG00000171611 (Ensembl)
Perforin-1ProteinP10820 (Uniprot-TrEMBL)
Pro-IL-18GeneProduct
ProteasomePathwayhsa03050 (KEGG Pathway)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductENSG00000169750 (Ensembl)
RAF-1MetaboliteHMDB03213 (HMDB)
RASA1GeneProductENSG00000145715 (Ensembl)
SGCAGeneProductENSG00000108823 (Ensembl)
SGCBGeneProductENSG00000163069 (Ensembl)
SGCDGeneProductENSG00000170624 (Ensembl)
SGCGGeneProductENSG00000102683 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRCProteinENSG00000197122 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
Sarcomere
T cell receptor alpha chain V regionGeneProduct
T-cell receptor beta chain V regionGeneProduct
TGFB1GeneProductENSG00000105329 (Ensembl)
TICAM1GeneProductTICAM1 (HGNC)
TLR3GeneProductENSG00000164342 (Ensembl)
  • low expression
  • Type your comment here
TLR4GeneProductENSG00000136869 (Ensembl)
  • low expression
  • Type your comment here
TLR5GeneProductENSG00000187554 (Ensembl)
  • high expression
  • Type your comment here
TNF-alphaGeneProduct
TNFRSM5ProteinP27512 (Uniprot-TrEMBL)
Tyrosine Kinase Protein
Viral entry CVB3GeneProduct
antigen
c-JunProteinQ9WVI9 (Uniprot-TrEMBL)
cardiac antigens
cd86 ProteinD3Z363 (Uniprot-TrEMBL)
glycophosphatidylinositol
hsp27Protein
matrix metalloproteinasesProtein
mature secreted forms
p53ProteinA0A0R4J1K8 (Uniprot-TrEMBL)
peptidoglycan muramyl dipeptideGeneProduct
pro-IL-1betaGeneProduct
prostaglandin E2MetaboliteCHEBI:606564 (ChEBI)
reactive oxygen species generatorsMetaboliteCHEBI:70982 (ChEBI)
striated muscle contractionPathwayWP383 (WikiPathways)
viral antigens

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4298"
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