Non-homologous end joining (Homo sapiens)

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1NHEJRecognitionDNA-PKcsKu80DNA-PKcsKu70Nbs1 ?DNA-PKcsLigase VXLFDNA-PKcsKu70RAD50Ku70DNA-PKcsKu70Ku70Ku70Ku80XRCC4DNA-PKcsKu80XRCC4Ku80Ku80Ku80Ku80Ku70Ku70MRE11ANHEJ1DNA-PKcsKu80DNA-PKcsKu70Ku80Ku70Ligase VKu80HREnd processingStrand invasion,DNA synthesis &resolutionLigation


Description

Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

http://en.wikipedia.org/wiki/Non-homologous_end_joining

This pathway is part the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wyman C, Kanaar R; ''DNA double-strand break repair: all's well that ends well.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
  2. ''KEGG''; https://www.genome.jp/dbget-bin/www_bget?pathway+hsa03450,
  3. ''REPAIRtoire''; http://repairtoire.genesilico.pl/Pathway/8/,

History

View all...
CompareRevisionActionTimeUserComment
127652view23:18, 13 November 2023Khanspersadded id and db for repairtoire lit ref
125302view17:43, 31 January 2023LarsgwFix reference
119305view13:08, 23 June 2021Finterlyadded KEGG biopax information
108414view00:07, 18 December 2019KhanspersAdded WRN and removed DNTT
108413view23:29, 17 December 2019Khanspersadded alternative processing steps based on REPAIRtoire
108412view23:12, 17 December 2019Khansperschanged complex and label
108052view00:48, 27 November 2019Khanspersadded references
108051view00:46, 27 November 2019KhanspersModified description
108045view20:22, 26 November 2019KhanspersOntology Term : 'DNA repair pathway' added !
108042view20:21, 26 November 2019Khansperschanged style and graphics
108035view16:09, 25 November 2019Khanspersremoved HR part
108033view07:13, 25 November 2019Khanspersoverhaul in progress
107721view12:24, 31 October 2019DeSlAdded steps to the left, added lit. ref.
107720view12:16, 31 October 2019DeSlChanged blue+black lines to graphical interactions.
107719view12:10, 31 October 2019DeSlChanged unconnected arrows to graphical lines.
107554view23:46, 19 October 2019AlexanderPicoModified description
105501view05:54, 8 August 2019KhanspersModified description
80022view20:57, 30 April 2015ZariCorrected Ensembl ID for DNA-PKcs
68977view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
59183view18:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45348view20:25, 7 October 2011KhanspersOntology Term : 'DOID:0014667' removed !
45346view20:25, 7 October 2011KhanspersOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
41150view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
39394view19:04, 20 November 2010Chetan1Ontology Term : 'disease of metabolism' added !
35395view09:48, 12 February 2010MartijnVanIerselModified description
32098view13:44, 14 August 2009MaintBotFixed group labels
29612view12:10, 23 May 2009MartijnVanIerselUpdated ensembl references
22671view14:58, 14 November 2008Thomascapitalized title
21602view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:non-homologous end joining]] moved to [[Pathway:WP438]]: Moved to stable identifier
15846view19:46, 5 June 2008KhanspersAdded gene IDs
14981view19:57, 24 May 2008AlexanderPicoGrouped and connected
9596view11:40, 9 January 2008Thomasadded to cellular process category
9588view10:18, 9 January 2008Thomasadded gene identifiers
9583view09:46, 9 January 2008Thomasmade a start with NHEJ pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNA-PKcsGeneProductENSG00000253729 (Ensembl)
Ku70GeneProductENSG00000196419 (Ensembl)
Ku80GeneProductENSG00000079246 (Ensembl)
Ligase VGeneProduct
MRE11AGeneProductENSG00000020922 (Ensembl)
NHEJ1GeneProductENSG00000187736 (Ensembl)
Nbs1 ?GeneProduct
RAD50GeneProductENSG00000113522 (Ensembl)
XLFGeneProduct79840 (Entrez Gene)
XRCC4GeneProductENSG00000152422 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP438"
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