Tryptophan metabolism (Homo sapiens)

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1, 2, 4, 5 Enterochromaffin CellFormyl-N-acetyl-5-methoxykynurenamineSerotonin2-Aminomuconate5-Methoxyindoleacetate2-AminomuconateCinnavalininate5-HydroxyindoleacetateQuinolinate4,8-Dihydroxyquinoline2-Oxoadipatemicrobial pathway interactionN-formylanthranilate2-Amino-3-carboxymuconateIndole-3-acetaldehyde5-hydroxykynurenamineIndole-3-acetateAnthranilateFormyl-5-hydroxykynurenamine3-Hydroxykynurenamine(S)-3-Hydroxybutyryl-CoA3-Hydroxyanthranilate3-Hydroxy-L-kynurenineDDCIndole-3-acetamideAcetoacetyl-CoAAcetyl-CoA6-HydroxymelatoninKYNUDDC1.5.1.-N-MethylserotoninECHS1AANATTDO2TMOACAT1ASMTKYNU5-Hydroxyindoleacetaldehyde5-Hydroxy-L-tryptophanN-MethyltryptamineHAAOTpH15-HydroxykynurenineBenzoate degradation via hydroxylationTrDIL4I1MelatoninMAOATPH2N-AcetylserotoninASMTTryptophol4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate4,6-DihydroxyquinolineFormylkynurenine4.1.1.-Glycolysis/GluconeogenesisGCDHINMTDLDXanthurenic acidALDH2AOC1Indole-3-aldehydeAADATGlutaryl-CoAACMSDAOX1MAOA5-Hydroxy-N-formylkynurenineTryptamineNicotinate and nicotinamide metabolismINMTCATCrotonoyl-CoAMAOAINDO2L-KynurenineALDH2L-TryptophanKMOAFMIDCYP1A1MAOAIDO2IDO1DDCPhenylalanine, Tyrosine and Tryptophan metabolismALDH8A1Indolepyruvate63IDO2AFMIDKYNUpicolinateHADHIDO2


Description

This pathway describes the metabolism of tryptophan, an essential amino acid.

Originally adapted from: KEGG, and expanded with information from Agus 2018, Dehhaghi 2019, and Gao 2020.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Qian Han, Tao Cai, Danilo A. Tagle, Jianyong Li; ''Structure, expression, and function of kynurenine aminotransferases in human and rodent brains''; Cell Mol Life Sci., 2010 PubMed Europe PMC Scholia
  2. Jessica M Yano, Kristie Yu, Gregory P Donaldson, Gauri G Shastri, Phoebe Ann, Liang Ma, Cathryn R Nagler, Rustem F Ismagilov, Sarkis K Mazmanian, Elaine Y Hsiao; ''Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis''; Cell, 2015 PubMed Europe PMC Scholia
  3. Allison Agus, Julien Planchais, Harry Sokol 2; ''Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease''; Cell Host Microbe, 2018 PubMed Europe PMC Scholia
  4. ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+rno00380,
  5. Kan Gao, Chun-Long Mu, Aitak Farzi, Wei-Yun Zhu; ''Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain''; Adv Nutr ., 2020 PubMed Europe PMC Scholia
  6. Mona Dehhaghi, Hamed Kazemi Shariat Panahi, Gilles J Guillemin; ''Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status''; Int J Tryptophan Res., 2019 PubMed Europe PMC Scholia
  7. Gary M Mawe, Jill M Hoffman; ''Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets''; Nat Rev Gastroenterol Hepatol., 2013 PubMed Europe PMC Scholia
  8. Jing Gao, Kang Xu, Hongnan Liu, Gang Liu, Miaomiao Bai, Can Peng, Tiejun Li, Yulong Yin; ''''; , PubMed Europe PMC Scholia
  9. Camille Martin-Gallausiaux, Pierre Larraufie, Anne Jarry, Fabienne Béguet-Crespe, Ludovica Marinelli, Florence Ledue, Frank Reimann, Hervé M Blottière, Nicolas Lapaque; ''Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 ( IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells''; Front Immunol., 2018 PubMed Europe PMC Scholia
  10. G Clarke, S Grenham, P Scully, P Fitzgerald, R D Moloney, F Shanahan, T G Dinan, J F Cryan; ''The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner''; Mol Psychiatry, 2013 PubMed Europe PMC Scholia
  11. Denisse Bravo, Anilei Hoare, Cristopher Soto, Manuel A Valenzuela, Andrew Fg Quest; ''Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects''; World J Gastroenterol., 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122957view14:15, 3 June 2022DeSlOntology Term : 'indoleamine and related compounds metabolic pathway' added !
122956view14:14, 3 June 2022DeSlOntology Term : 'indoleamine and related compounds biosynthetic pathway' added !
122955view14:13, 3 June 2022DeSlOntology Term : 'type EC enteroendocrine cell' added !
122954view14:13, 3 June 2022DeSlOntology Term : 'enterochromaffin-like cell' added !
122953view14:13, 3 June 2022DeSlOntology Term : 'regulatory pathway' added !
122952view14:12, 3 June 2022DeSlOntology Term : 'signaling pathway' added !
122951view14:12, 3 June 2022DeSlOntology Term : 'classic metabolic pathway' added !
122950view14:12, 3 June 2022DeSlOntology Term : 'aryl hydrocarbon receptor signaling pathway' added !
122949view14:12, 3 June 2022DeSlOntology Term : 'serotonin secreting cell' added !
122948view14:12, 3 June 2022DeSlOntology Term : 'kynurenine metabolic pathway' added !
122947view14:11, 3 June 2022DeSlOntology Term : 'tryptophan degradation pathway' added !
122946view14:11, 3 June 2022DeSlOntology Term : 'tryptophan biosynthetic pathway' added !
122945view14:10, 3 June 2022DeSlRemoved unconnected interaction
122944view14:05, 3 June 2022DeSlAdded serotonin stimuli
122943view13:54, 3 June 2022DeSlAdded HDAC regulation of IDO info.
122942view13:43, 3 June 2022DeSlAdded influence of butyrate to kynurenic PW
122941view13:20, 3 June 2022DeSlAdded details from Fig. 1 PMID:31825083
122940view13:09, 3 June 2022DeSlAdded more details from PMID: 31258331, Fig. 3
122939view12:48, 3 June 2022DeSlAdded more details on kynurenine PW
122938view12:30, 3 June 2022DeSlAdded more details from Agus et al to description.
122937view12:27, 3 June 2022DeSlAdded last step of Fig.2
122936view12:19, 3 June 2022DeSlFinalized annotation of INDOLE microbial genes/proteins
122935view11:48, 3 June 2022DeSlAdded more details for legend
122934view11:43, 3 June 2022DeSlAdded more microbial interactions to PW
122933view11:32, 3 June 2022DeSlAdded first microbial pathway interactions
122932view11:11, 3 June 2022DeSlAdded refs to PW
122931view11:06, 3 June 2022DeSlAdded more lit. refs to description
122928view10:07, 3 June 2022DeSlConnected unconnected line
122927view10:06, 3 June 2022DeSlAdded latest missing metabolite IDs.
122926view10:02, 3 June 2022DeSlUpdated last section of PW
122924view09:29, 3 June 2022DeSlChecked bottom part
122922view08:48, 3 June 2022DeSlChecked left middle section
122919view08:18, 3 June 2022DeSlStarting to remove elements not relevant for species.
119262view07:46, 23 June 2021Finterlyadded KEGG pathway info to publicationXref
113999view21:46, 16 December 2020EgonwAnother pathway clickable
106518view23:30, 5 September 2019Khanspersadded reference
106203view12:09, 16 August 2019MaintBotHMDB identifier normalization
105847view23:14, 15 August 2019KhanspersModified description
104898view15:43, 23 June 2019EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
104829view14:28, 19 June 2019Fehrhartadded some more metabolite IDs
104828view14:20, 19 June 2019Fehrhartadded metabolite IDs
104821view12:57, 19 June 2019FehrhartModified description
103977view02:10, 20 April 2019AlexanderPicoFixed EC6.3.2.-
102311view21:09, 17 December 2018KhanspersModified description
102310view21:08, 17 December 2018Khanspersremoved GenMAPP comment
94086view12:40, 18 August 2017DeSlModified description
93713view12:41, 11 August 2017DeSlModified description
85055view10:47, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
79226view18:51, 15 March 2015EgonwAdded a number of missing metabolite Chemspider identifiers (based on IUPAC names).
77387view12:04, 4 September 2014EgonwAdded a number of missing metabolite Chemspider identifiers (based on IUPAC names).

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-3-Hydroxy butyryl-CoAMetaboliteC01144 (KEGG Compound) (S)-3-Hydroxybutanoyl-CoA
1.5.1.-GeneProduct1.5.1.- (Enzyme Nomenclature) Unclear which specific protein acts in this reaction.
2-Amino-3-carboxymuconateMetaboliteC04409 (KEGG Compound) 2-Amino-3-carboxymuconate
2-AminomuconateMetaboliteC02220 (KEGG Compound) 2-Aminomuconate
2-AminomuconateMetaboliteC03824 (KEGG Compound) 2-Aminomuconate
2-OxoadipateMetabolite19951093 (Chemspider) 2-Oxoadipate
3-Hydroxy- L-kynurenineMetaboliteC03227 (KEGG Compound) AKA 3-Hydroxy-L-kynurenine, 3H-KYN
3-HydroxyanthranilateMetabolite7822291 (Chemspider) AKA 3-Hydroxyanthranilate, 3-HAA
3-HydroxykynurenamineMetaboliteHMDB0060281 (HMDB) 3-Hydroxykynurenamine
4,6-DihydroxyquinolineMetaboliteHMDB0004077 (HMDB)
4,8-DihydroxyquinolineMetaboliteCHEBI:28883 (ChEBI) 4,8-Dihydroxyquinoline
4-(2-Amino-3-hydroxyphenyl)- 2,4-dioxobutanoateMetaboliteHMDB0004083 (HMDB)
4.1.1.-GeneProduct4.1.1.- (Enzyme Nomenclature) Unclear which specific protein acts in this reaction
5-Hydroxy-L-tryptophanMetaboliteHMDB0000472 (HMDB) "The neurotransmitter 5-HT is produced in the brain through the Trp hydroxylase 2 enzyme (TpH2), [...], more than 90% of the body's 5-HT is produced in the gut and particularly in enterochromaffin cells (ECs), a specialized subtype of intestinal epithelial cell."
5-Hydroxy-N-formylkynurenineMetaboliteHMDB0004086 (HMDB)
5-HydroxyindoleacetaldehydeMetaboliteHMDB0004073 (HMDB) AKA 5-HIAA
5-HydroxyindoleacetateMetabolite10637170 (Chemspider) 5-Hydroxyindoleacetate
5-HydroxykynurenineMetabolite484-78-6 (CAS)
5-MethoxyindoleacetateMetabolite14533147 (Chemspider) 5-Methoxyindoleacetate
5-hydroxykynurenamineMetaboliteCHEBI:62214 (ChEBI) 5-Hydroxykynurenamine
6-HydroxymelatoninMetabolite2208-41-5 (CAS)
AADATGeneProduct56267 (Entrez Gene)
AANATGeneProduct15 (Entrez Gene)
ACAT1GeneProduct38 (Entrez Gene)
ACMSDGeneProduct130013 (Entrez Gene)
AFMIDGeneProduct125061 (Entrez Gene)
ALDH2GeneProduct217 (Entrez Gene)
ALDH2ProteinP05091 (Uniprot-TrEMBL)
ALDH8A1GeneProduct64577 (Entrez Gene)
AOC1GeneProduct26 (Entrez Gene) aka ABP1
AOX1GeneProduct316 (Entrez Gene)
ASMTGeneProduct438 (Entrez Gene)
Acetoacetyl-CoAMetaboliteC00332 (KEGG Compound)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
AnthranilateMetabolite4573598 (Chemspider) Anthranilate
Benzoate degradation via hydroxylationPathway
CATGeneProduct847 (Entrez Gene)
CYP1A1GeneProduct1543 (Entrez Gene)
CinnavalininateMetaboliteC05640 (KEGG Compound) Cinnavalininate
Crotonoyl-CoAMetaboliteC00877 (KEGG Compound)
DDCGeneProduct1644 (Entrez Gene) Known under two EC numbers: aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28; EC:4.1.1.105]
DLDGeneProduct1738 (Entrez Gene) aka OADH
ECHS1GeneProduct1892 (Entrez Gene)
Formyl-5-hydroxykynurenamineMetaboliteHMDB0012948 (HMDB)
Formyl-N-acetyl-5- methoxykynurenamineMetaboliteC05642 (KEGG Compound) Formyl-N-acetyl-5-methoxykynurenamine
FormylkynurenineMetabolite1022-31-7 (CAS) Formylkynurenine
GCDHGeneProduct2639 (Entrez Gene) predicted
Glutaryl-CoAMetaboliteC00527 (KEGG Compound)
Glycolysis/GluconeogenesisPathwayWP534 (WikiPathways)
HAAOGeneProduct23498 (Entrez Gene)
HADHProteinQ16836 (Uniprot-TrEMBL)
IDO1ProteinP14902 (Uniprot-TrEMBL) AKA indoleamine 2,3-dioxygenase, in both immune and epithelial cells [PMID: 22688187]
IDO2GeneProduct169355 (Entrez Gene)
IL4I1ProteinQ96RQ9 (Uniprot-TrEMBL)
INDO2GeneProduct3620 (Entrez Gene)
INMTGeneProduct11185 (Entrez Gene)
Indole-3-acetaldehydeMetabolite778 (Chemspider) AKA IAAId
Indole-3-acetamideMetaboliteCHEBI:16031 (ChEBI) AKA IAM
Indole-3-acetateMetabolite779 (Chemspider) AKA IAA, Indole Acetic Acid
Indole-3-aldehydeMetaboliteCHEBI:28238 (ChEBI) AKA IAId
IndolepyruvateMetaboliteC00331 (KEGG Compound)
KMOGeneProduct8564 (Entrez Gene)
KYNUGeneProduct8942 (Entrez Gene)
L-KynurenineMetabolite343-65-7 (CAS) L-Kynurenine
L-TryptophanMetabolite73-22-3 (CAS)
MAOAGeneProduct4128 (Entrez Gene) AKA Monoamine Ozydase (MAO)
MelatoninMetaboliteHMDB0001389 (HMDB)
N-AcetylserotoninMetabolite1210-83-9 (CAS) N-Acetylserotonin
N-MethylserotoninMetaboliteHMDB0004369 (HMDB)
N-MethyltryptamineMetaboliteCHEBI:28136 (ChEBI)
N-formylanthranilateMetaboliteQ27103061 (Wikidata) Formylanthranilate
Nicotinate and nicotinamide metabolismPathwayWP4210 (WikiPathways)
Phenylalanine, Tyrosine and Tryptophan metabolismPathwayWP3925 (WikiPathways)
QuinolinateMetabolite2777129 (Chemspider)
SerotoninMetabolite5013 (Chemspider) AKA 3-(2-Aminoethyl)-1H-indol-5-ol
TDO2GeneProduct6999 (Entrez Gene)
TMOProteinP48775 (Uniprot-TrEMBL) AKA Tryptophan 2,3-dioxygenase; abbreviation TMO is not know in UniProt (TDO2 is the gene name).
TPH2GeneProduct121278 (Entrez Gene) produced in the brain
TpH1ProteinP17752 (Uniprot-TrEMBL) AKA Trp hydroxylase 1, produced in intestinal epithelial cells.
TrDProteinAKA Tryptophan Decarboxylase; protein from different species, is also expressed in plants (e.g. tobacco, PMID:10712558]
TryptamineMetabolite61-54-1 (CAS)
TryptopholMetaboliteCHEBI:17890 (ChEBI)
Xanthurenic acidMetaboliteHMDB0000881 (HMDB)
picolinateMetaboliteC10164 (KEGG Compound)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP465"