Hedgehog signaling pathway (Homo sapiens)

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112, 41491, 414, 429, 498196, 273112, 414162, 332194, 29028, 79, 125, 162273, 326120, 394, 401124, 256249, 290114, 283EndosomesHedgehog Signaling PathwayCiliaGLI3ADRBK1IHHGLI2SUFUPTCH2SUFUSAP18DHHDHHKIF7GLI1STK36SMOSHHIHHSIN3AGLI2GLI3ARRB2SHHPTCH1STK36GLI1SMO112, 414Enzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageCYNUCYNUPMENProtein dissociation


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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128016view16:05, 21 January 2024EweitzRemove rogue elements, economize layout
128015view16:03, 21 January 2024EweitzAlign legend item, standardize case
126306view17:22, 20 April 2023EgonwLicense is CCZero
120579view17:58, 17 December 2021EweitzModified title
117750view12:48, 22 May 2021EweitzModified title
115907view10:42, 20 March 2021EgonwCopied the NetPath paper into the literature list
115906view09:57, 20 March 2021EgonwModified description
111020view14:28, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
107440view07:03, 8 October 2019DeSlModified title
78542view10:30, 7 January 2015MaintBotadded missing graphIds
70092view18:32, 12 July 2013MaintBotupdating to 2013 schema
47979view14:40, 23 April 2012NetPathModified description
45345view20:25, 7 October 2011AlexanderPicoOntology Term : 'Hedgehog signaling pathway' added !
44831view07:39, 6 October 2011Mkutmonconnected some lines
44830view07:38, 6 October 2011Mkutmonconnected some lines
44618view17:44, 22 September 2011KhanspersAdded category
44617view17:43, 22 September 2011KhanspersUpdating content to NetSlim
44115view20:42, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44039view23:26, 22 August 2011KhanspersModified description
44038view23:25, 22 August 2011KhanspersUpdating pathway from NetSlim
41187view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35650view21:41, 12 February 2010KhanspersModified description
35632view19:08, 12 February 2010AndraAdded references
20775view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Hedgehog Netpath 10]] moved to [[Pathway:WP47]]: Moved to stable identifier
14140view14:47, 21 May 2008Andraexercise
8126view13:46, 7 January 2008MaintBot[[Pathway:Human:Hedgehog Netpath 10]] moved to [[Pathway:Homo sapiens:Hedgehog Netpath 10]]: Renaming species
7684view16:09, 18 December 2007MaintBotfixed category names
7235view12:41, 4 November 2007MaintBotAdded categories to GPML
6331view22:17, 22 May 2007A.Pandeygpml file for [[Human:Hedgehog_Netpath_10]]

External references

DataNodes

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NameTypeDatabase referenceComment
ADRBK1GeneProduct156 (Entrez Gene)
ARRB2GeneProduct406 (Entrez Gene)
DHHGeneProduct50846 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
IHHGeneProduct3549 (Entrez Gene)
KIF7GeneProduct374654 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
PTCH1GeneProduct5727 (Entrez Gene)
PTCH2GeneProduct8643 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
ReceptorGeneProduct7040 (Entrez Gene)
SAP18GeneProduct10284 (Entrez Gene)
SHHGeneProduct6469 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SMOGeneProduct6608 (Entrez Gene)
STK36GeneProduct27148 (Entrez Gene)
SUFUGeneProduct51684 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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