Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex (Homo sapiens)

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T cell surface moleculesImmunoglobulin subunitsMembrane (M)T cell receptor(TCR)subunitsORF3a, ORF6, ORF7a, ORF7b, ORF8, ORF9a, ORF9b, and ORF10Envelope (E)SARS-CoV-2 viralproteinsMHC class II moleculesNucleocapsid (N)]Neutrophil activationTCR signaling kinaseschemotaxisGlycoprotein spike (S)nsp1 to nsp16IGLC2nsp10IGHG1CD8AHLA-DRB5CD8AIGHENKRFIGHG4CD2HLA-DRB1HLA-DRAIGLL1NLRP1nsp9PRG3IL-8IGHG2MMP25HLA-DRB4LBPCRPCD41IL-6CD247CD3GLCKCD3EZAP70TRBC1FYNTRACOpen reading frames (ORFs)SARS-CoV-2 (~30 kb)Structural proteinsNonstructural proteinsAccessory proteinsActivationPositive regulation of gene expressionNegative regulation of gene expressionLegend


Description

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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Ontology Terms

 

Bibliography

  1. Qiming Liang, Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, View ORCID ProfileYafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu; ''Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis''; https://doi.org/10.1101/2020.03.31.019216, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124646view13:05, 18 November 2022IsabelWassinkChanged viral protein shape to rounded rectangles
120646view15:34, 22 December 2021EweitzTighten graphics, fix labels
119112view13:26, 17 June 2021Finterlyadded PMID
118879view12:06, 3 June 2021EweitzOntology Term : 'COVID-19' added !
116727view10:25, 11 May 2021EweitzModified title
111618view20:42, 29 August 2020EgonwModified title
111113view09:20, 13 July 2020EgonwMade the include pathway clickable
110229view14:23, 27 April 2020EgonwAdded the NCBI gene identifier for LBP
110023view19:22, 12 April 2020AlexanderPicoOntology Term : 'regulatory pathway' added !
110022view19:21, 12 April 2020AlexanderPicoOntology Term : 'inflammatory response pathway' added !
110021view19:21, 12 April 2020AlexanderPicoOntology Term : 'disease pathway' added !
110020view19:20, 12 April 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
110019view19:20, 12 April 2020AlexanderPicoModified title
110017view19:18, 12 April 2020AlexanderPicoUpdated representation of ORFs and interactions per standards
109953view18:43, 7 April 2020EgonwAdded two identifiers.
109923view17:40, 6 April 2020Khanspersfixed unconnected
109916view16:58, 6 April 2020KhanspersOntology Term : 'viral infectious disease' added !
109904view19:59, 5 April 2020Rex D A BInteractions
109895view18:25, 4 April 2020Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Accessory proteinsPathway
Activation
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8AGeneProduct926 (Entrez Gene)
CRPGeneProduct1401 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IL-6GeneProduct3569 (Entrez Gene)
IL-8GeneProduct3576 (Entrez Gene)
LBPGeneProductLBP (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
Legend
MMP25 GeneProduct64386 (Entrez Gene)
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct5725029 (Entrez Gene)
Negative regulation of gene expression
Nonstructural proteinsPathway
Open reading frames (ORFs)Pathway
PRG3GeneProduct10394 (Entrez Gene)
Positive regulation of gene expression
SARS-CoV-2 (~30 kb)Pathway
Structural proteinsPathway
TRACGeneProduct28755 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)
nsp10Protein
nsp9Protein

Annotated Interactions

No annotated interactions

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