Urea cycle and metabolism of amino groups (Homo sapiens)

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Purine metabolismN-MethylhydantoinC03406N-Acetyl-L-glutamateN2-Acetyl-L-ornithineCO2N-Acetyl-L-glutamateAla and aspartate metabolismPhosphoguanidinoacetateFumarateCarbamoylGuanidinoacetateFormateD-Arg and D-ornithine metabolismNitrogen metabolismPro metabolismGlutamate metabolismPyrimidine metabolismN-CarbamoylsarcosineL-Aspartate5-semialdehyde(S)-1-Pyrroline-5-carboxylateCitrate cycle (TCA cycle)Urea-1-carboxylateArginine metabolismNH3Amino acid metabolismN-Acetyl-glutamateL-Glutamylcreatine-P3.5.1.59PYCRLNAGSSarcosineCPS1ARG2FormaldehydeSRMSpermineASL6.3.4.63.5.3.3PYCR1GAMTUreaL-ProlineL-Citrulline1.2.1.383.5.1.542.6.1.11ALDH18A13.5.1.5ALDH18A13.5.4.212.7.3.11.5.99.1L-Ornithine1.2.1.462.6.1.693.5.2.10SpermidineASS2.3.1.35PutrescineOATACY1ODC1ArginineARG1GATM3.5.1.16GLUD1CreatineCKMOTCL-Glutamate-L-Glutamate3.5.2.142.7.2.8CKBSMSSMSCreatinine


Description

No description

Comments

GenMAPP notes 
Converted from rat to human using ortholog information. Link to original KEGG map: http://www.genome.ad.jp/dbget-bin/show pathway?rno00220
GenMAPP remarks 
Edited by Sebastien Burel

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dahlman, Douglas L., Milan A. Berge.; ''Possible mechanisms for adverse effects of L-canavanine on insects.''; ACS Publications, 1986 DOI Scholia
  2. Seiler N; ''Ornithine aminotransferase, a potential target for the treatment of hyperammonemias.''; Curr Drug Targets, 2000 PubMed Europe PMC Scholia
  3. Deuschle K, Funck D, Hellmann H, Däschner K, Binder S, Frommer WB; ''A nuclear gene encoding mitochondrial Delta-pyrroline-5-carboxylate dehydrogenase and its potential role in protection from proline toxicity.''; Plant J, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
119105view10:02, 17 June 2021FinterlyAdded DOI, removed duplicate PublicationXref and fixed BiopaxRef
114002view21:55, 16 December 2020EgonwTwo more pathways clickable
105850view23:15, 15 August 2019KhanspersModified description
103837view12:35, 10 April 2019IreneHemelAdded Uniprot IDs
103836view11:00, 10 April 2019IreneHemelChanged datanodes for enzymes from geneproduct to protein
96019view15:13, 15 February 2018Mkutmonremoved old pathways attributes
96018view15:13, 15 February 2018MkutmonModified description
95281view18:12, 29 November 2017DeSlChanged several graphical lines to directed interactions + added litertaure references for these.
94180view13:40, 25 August 2017DeSlAdded ID for L-Glutamyl
92933view09:00, 20 July 2017EgonwFixed to the correct CAS number: it had the number of creatine.
72142view10:02, 25 October 2013Mkutmonadded datasource to EC numbers
71261view21:34, 16 October 2013MaintBotAutomated update of data sources
71169view11:01, 11 October 2013Mkutmonfixed unconnected lines
68976view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
45014view18:23, 6 October 2011KhanspersOntology Term : 'urea cycle pathway' added !
43586view14:08, 5 July 2011AdrienDefayadd database name for TCA
41149view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
38842view17:40, 24 September 2010Khanspers
38688view18:15, 23 September 2010KhanspersMore pathway links
38687view18:08, 23 September 2010KhanspersAdded pathway links and changed arrows and layout
38685view18:04, 23 September 2010KhanspersPeriodical save, work in progress
34435view18:15, 10 December 2009MaintBotAutomatic update of empty xrefs
32123view13:53, 14 August 2009MaintBotFixed group labels
21724view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Urea cycle and metabolism of amino groups KEGG]] moved to [[Pathway:WP497]]: Moved to stable identifier
13997view16:08, 20 May 2008Thomasconnected lines
13129view11:18, 17 May 2008MaintBotautomated metabolite conversion
8476view13:46, 7 January 2008MaintBot[[Pathway:Human:Urea cycle and metabolism of amino groups KEGG]] moved to [[Pathway:Homo sapiens:Urea cycle and metabolism of amino groups KEGG]]: Renaming species
7854view16:23, 18 December 2007MaintBotfixed category names
7413view12:42, 4 November 2007MaintBotAdded categories to GPML
6404view22:18, 22 May 2007L.M.Ferrantegpml file for [[Human:Urea_cycle_and_metabolism_of_amino_groups_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.2.1.38GeneProduct1.2.1.38
1.2.1.46GeneProduct1.2.1.46
1.5.99.1GeneProduct1.5.99.1
2.3.1.35GeneProduct2.3.1.35
2.6.1.11GeneProduct2.6.1.11
2.6.1.69GeneProduct2.6.1.69
2.7.2.8GeneProduct2.7.2.8
2.7.3.1GeneProduct2.7.3.1
3.5.1.16GeneProduct3.5.1.16
3.5.1.5GeneProduct3.5.1.5
3.5.1.54GeneProduct3.5.1.54
3.5.1.59GeneProduct3.5.1.59
3.5.2.10GeneProduct3.5.2.10
3.5.2.14GeneProduct3.5.2.14
3.5.3.3GeneProduct3.5.3.3
3.5.4.21GeneProduct3.5.4.21
6.3.4.6GeneProduct6.3.4.6
ACY1GeneProduct95 (Entrez Gene)
ALDH18A1GeneProduct5832 (Entrez Gene)
ARG1GeneProduct383 (Entrez Gene)
ARG2GeneProduct384 (Entrez Gene)
ASLGeneProduct435 (Entrez Gene)
ASSGeneProduct445 (Entrez Gene)
Arginine74-79-3 (CAS) L-Arginine
CKBGeneProduct1152 (Entrez Gene)
CKMGeneProduct1158 (Entrez Gene)
CPS1GeneProduct1373 (Entrez Gene)
Creatine57-00-1 (CAS) Creatine
Creatinine60-27-5 (CAS) Creatinine
Formaldehyde50-00-0 (CAS) Formaldehyde
GAMTGeneProduct2593 (Entrez Gene)
GATMGeneProduct2628 (Entrez Gene)
GLUD1GeneProduct2746 (Entrez Gene)
L-Citrulline372-75-8 (CAS) L-Citrulline
L-Glutamate-56-86-0 (CAS)
L-Glutamate56-86-0 (CAS) L-Glutamate
L-Ornithine70-26-8 (CAS) L-Ornithine
L-Proline147-85-3 (CAS) L-Proline
NAGSGeneProduct162417 (Entrez Gene)
OATGeneProduct4942 (Entrez Gene)
ODC1GeneProduct4953 (Entrez Gene)
OTCGeneProduct5009 (Entrez Gene)
PYCR1GeneProduct5831 (Entrez Gene)
PYCRLGeneProduct65263 (Entrez Gene)
Putrescine110-60-1 (CAS) Putrescine
SMSGeneProduct6611 (Entrez Gene)
SRMGeneProduct6723 (Entrez Gene)
Sarcosine107-97-1 (CAS) Sarcosine
Spermidine124-20-9 (CAS) Spermidine
Spermine71-44-3 (CAS) Spermine
Urea57-13-6 (CAS) Urea
creatine-P57-00-1 (CAS) Phosphocreatine

Annotated Interactions

No annotated interactions
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