Nephrogenesis (Homo sapiens)

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1from ureteric bud2. Primed nephron progenitor4. Comma Shaped StageStromal progenitor1. Induction of pretubular aggregate3. Epithelialized Renal VesicleNephron progenitor cellPretubular aggregateMEIS1PAX2ALDH1A2RSPO3FGF8GREB1LTCF21BMP7JAG1WNT9B FGF20WNT4LHX1FOXD1OSR1RSPO1SIX2NOTCH2


Description

This pathway describes the gene signalling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R; ''Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.''; Development, 2007 PubMed Europe PMC Scholia
  2. Vivante A, Mark-Danieli M, Davidovits M, Harari-Steinberg O, Omer D, Gnatek Y, Cleper R, Landau D, Kovalski Y, Weissman I, Eisenstein I, Soudack M, Wolf HR, Issler N, Lotan D, Anikster Y, Dekel B; ''Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling.''; J Am Soc Nephrol, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118777view15:58, 1 June 2021FehrhartOntology Term : 'CAKUT' added !
118775view15:56, 1 June 2021Fehrhartadded WNT4 interaction with WNT3A
115258view09:18, 8 February 2021FehrhartModified description
115255view09:02, 8 February 2021FehrhartOntology Term : 'kidney disease' added !
115254view09:02, 8 February 2021FehrhartOntology Term : 'Notch signaling pathway' added !
115253view09:01, 8 February 2021FehrhartOntology Term : 'signaling pathway' added !
115249view08:47, 8 February 2021FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALDH1A2GeneProductENSG00000128918 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GREB1LGeneProductENSG00000141449 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
LHX1GeneProductENSG00000274577 (Ensembl)
MEIS1GeneProductENSG00000143995 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
OSR1GeneProductENSG00000143867 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
RSPO1GeneProductENSG00000169218 (Ensembl)
RSPO3GeneProductENSG00000146374 (Ensembl)
SIX2GeneProductENSG00000170577 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT9B GeneProductENSG00000158955 (Ensembl)

Annotated Interactions

No annotated interactions

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