Pleural mesothelioma (Homo sapiens)

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14-3-314-3-324751333454134784314313541353313553, 4434137735543713435357MMTAMsGFsChronic inflammation, proliferation, angiogenesis,resistance to apoptosisChemokines, Cytokines,Pro-angiogenic factorsInflammationChemokines/Cytokines etc.AP-1 dependent genes/Repair genesUbiquination degradationDNA-damageWnt signalOther chemokines/cytokinesAutophagyIncreased protein synthesis+ Cell growthmTOR pathwayRTKsGrowth arrestCadherinsDegradationCell growth,differentiationCell survivalHippo-Merlin signalingCell growthMDM2-P53 signalingWNT pathwayMesothelial cellMAPK and JAK-STAT pathwaysIntegrinsInflammatory cytokines,cellular stressesTranscriptionMAPK pathwayAJUBAFZDERK2c-fosIL-1BERK5ROSRHEBPRAS40RAFMSIN1P53PDGFPIGFSFRPJAKMKMST1/2S6PRBAMOTE2FMEK3/6TSC1SOSGRB2TTI1FOXO1GSK3DKK1NLRP3ASKEIF4PIP2SETDB1GTPPIP3P16INK4ALEFPAK/RACSETD5LATS1p14ARFPTENBECLIN1JNK1-3MTORRAPTORApoptosisHIF1AMNKSHCBAP1MMP2BCL2ATMRAGEDVLRSKCDK7BTRCSAV1MCL1Cyclin DTSC2CDK4Hippo-Merlin signalingCyclinEBAKMEK5CUL1Cell cycleAPCc-jun4E-BPPUMARNSP21NF-KBCASPASE-1AXINHistone modificationsSETD2MEK4/7RASSTATMSKSRCGDPBAXTEL2ULK2TEADLRPTCFDNA repairFIP200S6KCyclinD1HMGB1MDM2MMP9MEK1/2KIBRADR5ATG13PI3K14-3-3MLST8DEPTORCTNNB1ULK1LATS2PDK1Angiogenesisfra-1CDK2VEGFFAKAKTMEKKBCLXLMLKRICTORERK1/2NF2/merlinMAPK14CDKN2A886RASMSKMNKMKTEL2TTI1MLST8DEPTORMTORYAPTAZMDM2P21BAXTAZCTNNB1Cell transformationTFCo-TFE2FPRBHMGB1HMGB1PRAS40RAPTORTEL2TTI1MLST8DEPTORMTORHMGB1IL-1BPro IL-1BP21YAPTAZChemokines, Cytokines,Pro-angiogenic factorsCell survival3Wnt signalingAutophagyCell migrationNucleusCTNNB1CTNNB1YAPTAZ


Description

Malignant Pleural Mesothelioma (MPM) is a rare type of cancer affecting the mesothelial cells of the lungs. 80% of the patients have been exposed to asbestos before being diagnosed, but only 5% of the people exposed to asbestos develop mesothelioma. Therefore, genetics are thought to play an important role in combination with asbestos' toxicological effects. Through a literature study, several pathways have been identified to contribute to the development of the disease, which are captured in this MPM pathway. Key mutated genes are highlighted in bold, and the pathway is divided into sections for clarity: A: mTOR dysregulation, B: MAPK signalling, C: JAK-STAT, D: Inflammation, E: Hippo-Merlin signalling, F: WNT signalling, G: Autophagy, H: MDM2 and P53

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
127398view20:36, 29 September 2023Khanspersupdated phospho sites
126829view09:08, 26 June 2023Marvin M2Modified description
126828view09:06, 26 June 2023Marvin M2Modified title
125314view21:41, 31 January 2023LarsgwAdd DOI to reference
124802view21:26, 11 December 2022AlexanderPicofixed citations
124785view06:42, 11 December 2022AlexanderPicofixed citations
122659view07:29, 27 April 2022Marvin M2Modified description
120373view20:34, 29 November 2021Marvin M2Connected line
120370view20:20, 29 November 2021Marvin M2Added comments for BAP1
120368view19:57, 29 November 2021Marvin M2Updated BAP1 section
120228view22:12, 15 November 2021Marvin M2Corrected PRC2 interactions
120227view22:05, 15 November 2021Marvin M2minor updates to BAP1 section
120212view21:31, 10 November 2021Marvin M2changed mutated genes view
120211view20:50, 10 November 2021Marvin M2Added HGNC symbols and ensembl IDs
120200view23:19, 8 November 2021ZiskaUpdated Ensembl IDs
120068view18:03, 26 October 2021Marvin M2Reshaped BAP1 section
119947view20:02, 27 September 2021Marvin M2Added list of biomarkers of prognosis
119931view20:20, 22 September 2021Marvin M2Legend added
119827view17:04, 29 August 2021Marvin M2Corrected mutated genes
119809view16:45, 26 August 2021Marvin M2Modified description
119808view15:53, 26 August 2021Marvin M2Added more detail and frequently mutated genes
119807view13:14, 26 August 2021Marvin M2Added MAPK target genes
119806view12:32, 26 August 2021Marvin M2Worked on MAPK pathway
119805view21:15, 25 August 2021Marvin M2Improved top left section
119804view20:04, 25 August 2021Marvin M2Improved, added frequently mutated genes.
119739view08:05, 11 August 2021L DupuisConnected lines
119730view12:29, 10 August 2021ZiskaExtended Wnt pathway
119729view19:44, 9 August 2021ZiskaAdded phosphorylation steps in Hippo signaling
119680view18:06, 28 July 2021EgonwFixed a reference
119679view18:04, 28 July 2021EgonwReplaced secondary ChEBI identifiers with primary ones.
119668view12:40, 28 July 2021Marvin M2Added JNKs
119667view12:22, 28 July 2021Marvin M2Cleaning hippo part
119666view12:11, 28 July 2021Marvin M2Improved hippo pathway part
119659view10:58, 28 July 2021Marvin M2Added content in microenvironment
119654view09:58, 28 July 2021Marvin M2Made space and added microenvironment parts
119642view00:10, 28 July 2021ZiskaExtended Hippo-Merlin signalling
119641view20:58, 27 July 2021Marvin M2Added secretions by mesothelioma
119640view20:12, 27 July 2021Marvin M2Added ECM content, and MMP regulations
119630view20:52, 23 July 2021Marvin M2Added ECM-linked hippo signaling, pathway nodes, and started miroenvironment interactions
119629view13:16, 23 July 2021ZiskaAdded regulation of TERT
119595view11:31, 21 July 2021Marvin M2improved annotations
119594view11:23, 21 July 2021Marvin M2Labels added
119586view08:54, 21 July 2021Marvin M2Red coloring for tumor suppressor genes
119580view15:41, 20 July 2021Marvin M2Minor graphical updates
119579view15:33, 20 July 2021Marvin M2Modified description
119578view15:25, 20 July 2021Marvin M2Added pathway nodes, histone modifications
119576view15:59, 19 July 2021Marvin M2Pathway nodes added
119575view15:46, 19 July 2021Marvin M2Added CDKN2A and transcripts
119568view11:59, 16 July 2021ZiskaChanged shapes and colors and turnt headings into letters
119094view08:20, 17 June 2021FinterlyRemoved PublicationXref and corresponding BiopaxRef with no information

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3ProteinA0A0J9YWE8 (Uniprot-TrEMBL)
4E-BPGeneProductENSG00000187840 (Ensembl)
AJUBAGeneProductENSG00000129474 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
AMOTGeneProductENSG00000126016 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ASKGeneProductENSG00000115687 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
AngiogenesisPathwayWP1993 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
BAKGeneProductENSG00000030110 (Ensembl)
BAP1GeneProductENSG00000163930 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCLXLGeneProductENSG00000171791 (Ensembl)
BECLIN1GeneProductENSG00000126581 (Ensembl)
BTRCGeneProductENSG00000166167 (Ensembl)
CASPASE-1GeneProductENSG00000137752 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CDKN2AGeneProductCDKN2A (HGNC)
CTNNB1GeneProduct1499 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CUL1GeneProductENSG00000055130 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
Cell migrationPathwayWP4561 (WikiPathways)
Cyclin DGeneProductENSG00000110092 (Ensembl)
CyclinD1GeneProductENSG00000110092 (Ensembl)
CyclinEGeneProductENSG00000105173 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DNA repairPathwayWP4946 (WikiPathways)
DR5GeneProductENSG00000196363 (Ensembl)
DVLGeneProductENSG00000107404 (Ensembl)
E2FGeneProductENSG00000101412 (Ensembl)
EIF4GeneProductENSG00000114867 (Ensembl)
ERK1/2GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
ERK5GeneProductENSG00000166484 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FZDGeneProductENSG00000157240 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
HIF1AGeneProductENSG00000100644 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
Hippo-Merlin signalingPathwayWP4541 (WikiPathways)
Histone modificationsPathwayWP2369 (WikiPathways)
IL-1BGeneProductENSG00000125538 (Ensembl)
JAKGeneProductENSG00000162434 (Ensembl)
JNK1-3GeneProductENSG00000107643 (Ensembl)
KIBRAGeneProductENSG00000113645 (Ensembl)
LATS1GeneProductENSG00000131023 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
LEFGeneProductENSG00000138795 (Ensembl)
LRPGeneProductENSG00000123384 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MEK1/2GeneProductENSG00000169032 (Ensembl)
MEK3/6GeneProductENSG00000034152 (Ensembl)
MEK4/7GeneProductENSG00000065559 (Ensembl)
MEK5GeneProductENSG00000137764 (Ensembl)
MEKKGeneProductENSG00000095015 (Ensembl)
MKGeneProductENSG00000110492 (Ensembl)
MLKGeneProductENSG00000168404 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MNKGeneProductENSG00000079277 (Ensembl)
MSIN1GeneProductENSG00000119487 (Ensembl)
MSKGeneProductENSG00000100784 (Ensembl)
MST1/2GeneProductENSG00000173531 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NF-KBGeneProductENSG00000109320 (Ensembl)
NF2/merlinGeneProductENSG00000186575 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
P16INK4AGeneProductP42771 (Uniprot-TrEMBL)
P21GeneProductENSG00000124762 (Ensembl)
P53GeneProductENSG00000141510 (Ensembl)
PAK/RACGeneProductENSG00000149269 (Ensembl)
PDGFGeneProductENSG00000197461 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIGFGeneProductENSG00000151665 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRBGeneProductENSG00000251655 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PUMAGeneProductENSG00000105327 (Ensembl)
Pro IL-1BGeneProductENSG00000125538 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAGEGeneProductENSG00000204305 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RNSMetaboliteQ225595 (Wikidata)
ROSMetaboliteCHEBI:70982 (ChEBI)
RSKGeneProductENSG00000160469 (Ensembl)
S6GeneProductENSG00000137154 (Ensembl)
S6KGeneProductENSG00000071242 (Ensembl)
SAV1GeneProductENSG00000151748 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SETD5GeneProductENSG00000168137 (Ensembl)
SETDB1GeneProductENSG00000143379 (Ensembl)
SFRPGeneProductENSG00000104332 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STATGeneProductENSG00000115415 (Ensembl)
TAZGeneProduct25937 (Entrez Gene)
TAZGeneProductENSG00000102125 (Ensembl)
TCFGeneProductENSG00000081059 (Ensembl)
TEADGeneProductENSG00000187079 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
VEGFGeneProductENSG00000112715 (Ensembl)
Wnt signalingPathwayWP428 (WikiPathways)
YAPGeneProductENSG00000137693 (Ensembl)
c-fosMetaboliteCHEBI:62519 (ChEBI)
c-junGeneProductENSG00000177606 (Ensembl)
fra-1 GeneProductENSG00000175592 (Ensembl)
p14ARFProteinQ8N726 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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