Pleural mesothelioma (Homo sapiens)

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14-3-314-3-37726826177777, 8101137, 1731010771027, 2810331031031010103726101010726147103101442551515552624519121924241519152415152425152426192425242524242315191924, 251622524152425192524242524152425262519252522452426TAMsMMChronic inflammation, proliferation, angiogenesis,resistance to apoptosisAMPKGrowth arresta-cateninIntegrinsCollagenolysisJNKsClea this. Some GFs bind particular RTKsCancer-associated fibroblastsLAT1Tumorigenesis & ProliferationIntegrinsMesothelial cellWNT pathwayWnt signalRTKsTranscriptionDegradationHippo-Merlin signalingStiff and fibronectin rich ECMOther chemokines/cytokinesUbiquination degradationMAPK pathwayInflammatory cytokines,cellular stressesCell survivalInflammationCell growth,differentiationChemokines, Cytokines,Pro-angiogenic factorsAutophagyMDM2-P53 signalingChemokines/Cytokines etc.MetastasisAngiogenesisDNA methylationGenetic aberrationsCell survival & growthReplicative immortalityAP-1 dependent genes/Repair genesCadherinsCell growthmTOR pathwayIncreased protein synthesis+ Cell growthDNA-damageMAPK and JAK-STAT pathwaysMAPK8FGF2ACTA1RASSF6RASSF5LIMD1LGALS9CCND1PLCB4SLC3A2FGF1LIN28BRAFCTGFKITLGHGFITGB1MYCCTGFHBEGFHGFFOXM1VEGFAPD-L1IGF1RASSF2RASSF4CTNNA1FGF2TGFAIL10CXCL12AREGCSF1IGF1RITGA1FN1RASSF1SLC2A1IL6let-7FGFR1LAMA1CCL2CSF2BTCCOL4A1RASSF7ACTA2CCL2RASSF3ACTBPDGFRATGFB1CD44KITMETIDO1EGFRLAMC1glucoseVGLL477, 8CDK4Histone modificationsP53DVLTCFBCL2CDKN2A20BAXRAGECyclinE14-3-3HIF1APIP3MCL1MMP9CDK7PDK1ASKNF2RASNF-KBS6DNA repairPRAS40DEPTORSFRPMEK5GRB2TSC1CUL1ATMSTATSP1S6KROSMAPK14SHCAPCTEL2FZDSAV1ERK2MEKKLATS1ATG13JAKP21CDK2Cell cycleSETD2MSKAngiogenesisULK223HMGB1c-fosMMP2MEK4/7E2FLATS223PDGFGDPBTRCMAXKIBRACyclin DGABPACTNNB1AKTIL-1BFOXO1PUMAMST1MSIN1RICTORERK1/2EIF4c-junNLRP3DKK1P16INK4ALEFVEGFFAKRHEBMDM2AJUBAMNKSETD5RSKMEK1/2MLKPIGFfra-1TEAD1TSC2PIP2GSK3CASPASE-1AMOTAXINRNSc-MycDR54E-BPSRCLRPBAP1MTORRAPTORPTENERK5MEK3/6TERT6, 9BECLIN1MKGTPBAKApoptosisMYCULK1SETDB1MLST8MAD1BCLXLPRBPI3Kp14ARFSOSTTI1STATAP2CyclinD1FIP200RASMSKMNKMKTEL2TTI1MLST8DEPTORMTORYAPTAZMDM2P21BAXCTNNB1Cell transformationE2FPRBHMGB1HMGB1PRAS40RAPTORTEL2TTI1MLST8DEPTORMTORHMGB1IL-1BPro IL-1BP21YAPTAZChemokines, Cytokines,Pro-angiogenic factorsCell survival24Wnt signalingAutophagyCell migrationNucleusCTNNB1CTNNB1NF-KBSRCNF2PAK1PAK2PAK3PAK4PAK5PAK626MAPK signaling pathwayMicroenvironment interactionsAngiogenesisVEGFBVEGFCVEGFD7TGFB1IL6PDGFAPDGFBPDGFCPDGFDMMP2MMP321MMP921MMP14EGF11FGFR2FGFR3FGFR4101010IGF2METPDGFRBCOL4A27COL4A37, 8COL4A4COL4A5COL4A6LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3ITGA2ITGA3ITGA4ITGAVITGA6ITGB2ITGB3ITGB4LamininsFN17COL4A1COL4A2COL4A37COL4A4COL4A5COL4A6LAMA1LAMC1LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3CCL4CXCL10CXCL5CXCL12TGFB1VEGFAVEGFBVEGFCVEGFDglucoseSLC7A5ArginineArginineTryptophanTryptophanKynurenineTumor-associated macrophagesIL34PhagocytosisCXCL5CXCL12TGFB1T-LymphocytesCXCL5CXCL1IL6CXCL12CSF3PD-L1IL10Myeloid-Derived Suppressor Cellsprostaglandin E2CDH5CDH1CDH10CDH17CDH9CDH16CDH6CDH13CDH20CDH2CDH19CDH22CDH8CDH24CDH18CDH12CDH7CDH15CDH11CDH3CDH4PRKAB2PRKAB1PRKAA2PRKAG1PRKAA1PRKAG2PRKAG3FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKFLT3NTRK1NTRK2RASMOB1AEFNA1FGF1FGF11FGF10EFNA2EGFFGF12CSF1ANGPT4ANGPT2ANGPT1VEGFAEFNA3EFNA4EFNA5FGF14FGF5FGF19FGF17FGF18FGF2FGF3FGF4FGF6FGF7FGF8FGF9VEGFDHGFIGF1IGF2INSKITLGKik1b4FLT3LGVEGFCVEGFBPDGFBPGFPDGFANGFPDGFCFGF21FGF23FGF22PDGFDFGF20FGF13Growth FactorFGF19NTF3NTF4BDNFTGFAROSVEGFAVEGFBVEGFCVEGFDCCL517CD47ACTC1ACTG1ACTG2ITGB1ITGA1ITGA2ITGA3ITGA4ITGAVITGA6CTNNA2CTNNA3B1-integrinExplore this integrin and how this affects NF2MOB1BTAZTEAD2TEAD3TEAD426STK3MAPK9MAPK10MAPK8MAPK9MAPK10JNKs26Functions of MMPsMINK1TNIKMAP4K1MAP4K2MAP4K4MAP4K3PSTK38LNDRG1


Description

Malignant Pleural Mesothelioma (MPM) is a rare type of cancer affecting the mesothelial cells of the lungs. 80% of the patients have been exposed to asbestos before being diagnosed, but only 5% of the people exposed to asbestos develop mesothelioma. Therefore, genetics are thought to play an important role in combination with asbestos' toxicological effects. Through a literature study, several pathways have been identified to contribute to the development of the disease, which are captured in this MPM pathway. Key mutated genes are highlighted in bold, and the pathway is divided into sections for clarity: A: mTOR dysregulation, B: MAPK signalling, C: JAK-STAT, D: Inflammation, E: Hippo-Merlin signalling, F: WNT signalling, G: Autophagy, H: MDM2 and P53

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
127398view20:36, 29 September 2023Khanspersupdated phospho sites
126829view09:08, 26 June 2023Marvin M2Modified description
126828view09:06, 26 June 2023Marvin M2Modified title
125314view21:41, 31 January 2023LarsgwAdd DOI to reference
124802view21:26, 11 December 2022AlexanderPicofixed citations
124785view06:42, 11 December 2022AlexanderPicofixed citations
122659view07:29, 27 April 2022Marvin M2Modified description
120373view20:34, 29 November 2021Marvin M2Connected line
120370view20:20, 29 November 2021Marvin M2Added comments for BAP1
120368view19:57, 29 November 2021Marvin M2Updated BAP1 section
120228view22:12, 15 November 2021Marvin M2Corrected PRC2 interactions
120227view22:05, 15 November 2021Marvin M2minor updates to BAP1 section
120212view21:31, 10 November 2021Marvin M2changed mutated genes view
120211view20:50, 10 November 2021Marvin M2Added HGNC symbols and ensembl IDs
120200view23:19, 8 November 2021ZiskaUpdated Ensembl IDs
120068view18:03, 26 October 2021Marvin M2Reshaped BAP1 section
119947view20:02, 27 September 2021Marvin M2Added list of biomarkers of prognosis
119931view20:20, 22 September 2021Marvin M2Legend added
119827view17:04, 29 August 2021Marvin M2Corrected mutated genes
119809view16:45, 26 August 2021Marvin M2Modified description
119808view15:53, 26 August 2021Marvin M2Added more detail and frequently mutated genes
119807view13:14, 26 August 2021Marvin M2Added MAPK target genes
119806view12:32, 26 August 2021Marvin M2Worked on MAPK pathway
119805view21:15, 25 August 2021Marvin M2Improved top left section
119804view20:04, 25 August 2021Marvin M2Improved, added frequently mutated genes.
119739view08:05, 11 August 2021L DupuisConnected lines
119730view12:29, 10 August 2021ZiskaExtended Wnt pathway
119729view19:44, 9 August 2021ZiskaAdded phosphorylation steps in Hippo signaling
119680view18:06, 28 July 2021EgonwFixed a reference
119679view18:04, 28 July 2021EgonwReplaced secondary ChEBI identifiers with primary ones.
119668view12:40, 28 July 2021Marvin M2Added JNKs
119667view12:22, 28 July 2021Marvin M2Cleaning hippo part
119666view12:11, 28 July 2021Marvin M2Improved hippo pathway part
119659view10:58, 28 July 2021Marvin M2Added content in microenvironment
119654view09:58, 28 July 2021Marvin M2Made space and added microenvironment parts
119642view00:10, 28 July 2021ZiskaExtended Hippo-Merlin signalling
119641view20:58, 27 July 2021Marvin M2Added secretions by mesothelioma
119640view20:12, 27 July 2021Marvin M2Added ECM content, and MMP regulations
119630view20:52, 23 July 2021Marvin M2Added ECM-linked hippo signaling, pathway nodes, and started miroenvironment interactions
119629view13:16, 23 July 2021ZiskaAdded regulation of TERT
119595view11:31, 21 July 2021Marvin M2improved annotations
119594view11:23, 21 July 2021Marvin M2Labels added
119586view08:54, 21 July 2021Marvin M2Red coloring for tumor suppressor genes
119580view15:41, 20 July 2021Marvin M2Minor graphical updates
119579view15:33, 20 July 2021Marvin M2Modified description
119578view15:25, 20 July 2021Marvin M2Added pathway nodes, histone modifications
119576view15:59, 19 July 2021Marvin M2Pathway nodes added
119575view15:46, 19 July 2021Marvin M2Added CDKN2A and transcripts
119568view11:59, 16 July 2021ZiskaChanged shapes and colors and turnt headings into letters
119094view08:20, 17 June 2021FinterlyRemoved PublicationXref and corresponding BiopaxRef with no information

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3ProteinA0A0J9YWE8 (Uniprot-TrEMBL)
4E-BPGeneProductENSG00000187840 (Ensembl)
ACTA1GeneProductENSG00000143632 (Ensembl)
ACTA2GeneProductENSG00000107796 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTC1GeneProductENSG00000159251 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTG2GeneProductENSG00000163017 (Ensembl)
AJUBAGeneProductENSG00000129474 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
AMOTGeneProductENSG00000126016 (Ensembl)
ANGPT1GeneProductENSG00000154188 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11600
ANGPT2GeneProductENSG00000091879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11601
ANGPT4GeneProductENSG00000101280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11602
AP2GeneProductENSG00000170323 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
ASKGeneProductENSG00000115687 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
AngiogenesisPathwayWP1993 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
ArginineMetaboliteCHEBI:29016 (ChEBI)
AutophagyPathwayWP4923 (WikiPathways)
BAKGeneProductENSG00000030110 (Ensembl)
BAP1GeneProductENSG00000163930 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCLXLGeneProductENSG00000171791 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
BECLIN1GeneProductENSG00000126581 (Ensembl)
BTCGeneProductENSG00000174808 (Ensembl)
BTRCGeneProductENSG00000166167 (Ensembl)
CASPASE-1GeneProductENSG00000137752 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CD47GeneProductENSG00000196776 (Ensembl)
CDH10GeneProduct1008 (Entrez Gene) Cadherin
CDH11GeneProduct1009 (Entrez Gene) Cadherin
CDH12GeneProduct1010 (Entrez Gene) Cadherin
CDH13GeneProduct1012 (Entrez Gene) Cadherin
CDH15GeneProduct1013 (Entrez Gene) Cadherin
CDH16GeneProduct1014 (Entrez Gene) Cadherin
CDH17GeneProduct1015 (Entrez Gene) Cadherin
CDH18GeneProduct1016 (Entrez Gene) Cadherin
CDH19GeneProduct28513 (Entrez Gene) Cadherin
CDH1GeneProduct999 (Entrez Gene) Cadherin
CDH20GeneProduct28316 (Entrez Gene) Cadherin
CDH2GeneProduct1000 (Entrez Gene) Cadherin
CDH22GeneProduct64405 (Entrez Gene) Cadherin
CDH24GeneProduct64403 (Entrez Gene) Cadherin
CDH3GeneProduct1001 (Entrez Gene) Cadherin
CDH4GeneProduct1002 (Entrez Gene) Cadherin
CDH5GeneProduct1003 (Entrez Gene) Cadherin
CDH6GeneProduct1004 (Entrez Gene) Cadherin
CDH7GeneProduct1005 (Entrez Gene) Cadherin
CDH8GeneProduct1006 (Entrez Gene) Cadherin
CDH9GeneProduct1007 (Entrez Gene) Cadherin
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CDKN2AGeneProductCDKN2A (HGNC)
COL4A1GeneProductENSG00000187498 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProductENSG00000081052 (Ensembl)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProductENSG00000197565 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12977
CSF1RGeneProductENSG00000182578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
CTNNA1GeneProductENSG00000044115 (Ensembl)
CTNNA2GeneProductENSG00000066032 (Ensembl)
CTNNA3GeneProductENSG00000183230 (Ensembl)
CTNNB1GeneProduct1499 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CUL1GeneProductENSG00000055130 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL12GeneProduct6387 (Entrez Gene)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL5GeneProductENSG00000163735 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
Cell migrationPathwayWP4561 (WikiPathways)
Cyclin DGeneProductENSG00000110092 (Ensembl)
CyclinD1GeneProductENSG00000110092 (Ensembl)
CyclinEGeneProductENSG00000105173 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DNA repairPathwayWP4946 (WikiPathways)
DR5GeneProductENSG00000196363 (Ensembl)
DVLGeneProductENSG00000107404 (Ensembl)
E2FGeneProductENSG00000101412 (Ensembl)
EFNA1GeneProductENSG00000169242 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13636
EFNA2GeneProductENSG00000099617 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13637
EFNA3GeneProductENSG00000143590 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13638
EFNA4GeneProductENSG00000243364 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13639
EFNA5GeneProductENSG00000184349 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
EGFGeneProductENSG00000138798 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13645
EGFRGeneProductENSG00000146648 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
EIF4GeneProductENSG00000114867 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
ERK1/2GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
ERK5GeneProductENSG00000166484 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FGF10GeneProductENSG00000070193 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14165
FGF11GeneProductENSG00000161958 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14166
FGF12GeneProductENSG00000114279 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14167
FGF13GeneProductENSG00000129682 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80903
FGF14GeneProductENSG00000102466 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14169
FGF17GeneProductENSG00000158815 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14171
FGF18GeneProductENSG00000156427 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF19GeneProductENSG00000162344 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF1GeneProductENSG00000113578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14164
FGF20GeneProductENSG00000078579 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80857
FGF21GeneProductENSG00000105550 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56636
FGF2GeneProduct2247 (Entrez Gene)
FGF22GeneProductENSG00000070388 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67112
FGF23GeneProductENSG00000118972 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14173
FGF3GeneProductENSG00000186895 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14174
FGF4GeneProductENSG00000075388 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14175
FGF5GeneProductENSG00000138675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14168
FGF6GeneProductENSG00000111241 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14177
FGF7GeneProductENSG00000140285 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14178
FGF8GeneProductENSG00000107831 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14179
FGF9GeneProductENSG00000102678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14180
FGFR1GeneProductENSG00000077782 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
FGFR2GeneProductENSG00000066468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
FGFR3GeneProductENSG00000068078 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
FGFR4GeneProductENSG00000160867 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FIP200GeneProductENSG00000023287 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT3GeneProductENSG00000122025 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FLT3LGGeneProductENSG00000090554 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FN1GeneProductENSG00000115414 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FZDGeneProductENSG00000157240 (Ensembl)
GABPAGeneProductENSG00000154727 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
HBEGFGeneProductENSG00000113070 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15234
HGFGeneProductHGF (HGNC)
HIF1AGeneProductENSG00000100644 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
Histone modificationsPathwayWP2369 (WikiPathways)
IDO1GeneProductENSG00000131203 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16000
IGF1RGeneProductENSG00000140443 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
IGF2GeneProductENSG00000167244 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
IL-1BGeneProductENSG00000125538 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL34GeneProductENSG00000157368 (Ensembl)
IL6GeneProduct3569 (Entrez Gene)
IL6GeneProductENSG00000136244 (Ensembl)
INSGeneProductENSG00000254647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16334
INSRGeneProductENSG00000171105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITGB4GeneProductENSG00000132470 (Ensembl)
JAKGeneProductENSG00000162434 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
KIBRAGeneProductENSG00000113645 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
KITLGGeneProductENSG00000049130 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17311
Kik1b4GeneProduct
KynurenineMetaboliteCHEBI:28683 (ChEBI)
LAMA1GeneProductENSG00000101680 (Ensembl)
LAMA2GeneProductENSG00000196569 (Ensembl)
LAMA3GeneProductENSG00000053747 (Ensembl)
LAMA4GeneProductENSG00000112769 (Ensembl)
LAMA5GeneProductENSG00000130702 (Ensembl)
LAMB1GeneProductENSG00000091136 (Ensembl)
LAMB2GeneProductENSG00000172037 (Ensembl)
LAMB3GeneProductENSG00000196878 (Ensembl)
LAMC1GeneProductENSG00000135862 (Ensembl)
LAMC2GeneProductENSG00000058085 (Ensembl)
LAMC3GeneProductENSG00000050555 (Ensembl)
LATS1GeneProductENSG00000131023 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
LEFGeneProductENSG00000138795 (Ensembl)
LGALS9GeneProductENSG00000168961 (Ensembl)
LIMD1GeneProductENSG00000144791 (Ensembl)
LIN28BGeneProductENSG00000187772 (Ensembl)
LRPGeneProductENSG00000123384 (Ensembl)
MAD1GeneProductENSG00000002822 (Ensembl)
MAP4K1GeneProductENSG00000104814 (Ensembl)
MAP4K2GeneProductENSG00000168067 (Ensembl)
MAP4K3GeneProductENSG00000011566 (Ensembl)
MAP4K4GeneProductENSG00000071054 (Ensembl)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAXGeneProductENSG00000125952 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MEK1/2GeneProductENSG00000169032 (Ensembl)
MEK3/6GeneProductENSG00000034152 (Ensembl)
MEK4/7GeneProductENSG00000065559 (Ensembl)
MEK5GeneProductENSG00000137764 (Ensembl)
MEKKGeneProductENSG00000095015 (Ensembl)
METGeneProduct4233 (Entrez Gene)
METGeneProductENSG00000105976 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
MINK1GeneProductENSG00000141503 (Ensembl)
MKGeneProductENSG00000110492 (Ensembl)
MLKGeneProductENSG00000168404 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MMP14GeneProductENSG00000157227 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MNKGeneProductENSG00000079277 (Ensembl)
MOB1AGeneProductENSG00000114978 (Ensembl)
MOB1BGeneProductENSG00000173542 (Ensembl)
MSIN1GeneProductENSG00000119487 (Ensembl)
MSKGeneProductENSG00000100784 (Ensembl)
MST1GeneProductENSG00000173531 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NDRG1GeneProduct10397 (Entrez Gene) NDR1/2
NF-KBGeneProductENSG00000109320 (Ensembl)
NF2GeneProductENSG00000186575 (Ensembl)
NGFGeneProductENSG00000134259 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18049
NGFRGeneProductENSG00000064300 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
NLRP3GeneProductENSG00000162711 (Ensembl)
NTF3GeneProductENSG00000185652 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
NTF4GeneProductENSG00000225950 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
NTRK1GeneProductENSG00000198400 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
P16INK4AGeneProductP42771 (Uniprot-TrEMBL)
P21GeneProductENSG00000124762 (Ensembl)
P53GeneProductENSG00000141510 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PAK2GeneProductENSG00000180370 (Ensembl)
PAK3GeneProductENSG00000077264 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAK5GeneProductENSG00000101349 (Ensembl)
PAK6GeneProductPAK6 (HGNC)
PD-L1GeneProductENSG00000120217 (Ensembl)
PDGFAGeneProductENSG00000197461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18590
PDGFAGeneProductPDGFA (HGNC)
PDGFBGeneProductENSG00000100311 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18591
PDGFBGeneProductPDGFB (HGNC)
PDGFCGeneProductENSG00000145431 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54635
PDGFCGeneProductPDGFC (HGNC)
PDGFDGeneProductENSG00000170962 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
PDGFDGeneProductPDGFD (HGNC)
PDGFGeneProductENSG00000197461 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRBGeneProductENSG00000113721 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
PDK1GeneProductENSG00000152256 (Ensembl)
PGFGeneProductENSG00000119630 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
PI3KGeneProductENSG00000121879 (Ensembl)
PIGFGeneProductENSG00000151665 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCB4GeneProductENSG00000101333 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRBGeneProductENSG00000251655 (Ensembl)
PRKAA1GeneProduct5562 (Entrez Gene) AMPK
PRKAA2GeneProduct5563 (Entrez Gene) AMPK
PRKAB1GeneProduct5564 (Entrez Gene) AMPK
PRKAB2GeneProduct5565 (Entrez Gene) AMPK
PRKAG1GeneProduct5571 (Entrez Gene) AMPK
PRKAG2GeneProduct51422 (Entrez Gene) AMPK
PRKAG3GeneProduct53632 (Entrez Gene) AMPK
PTENGeneProductENSG00000171862 (Ensembl)
PUMAGeneProductENSG00000105327 (Ensembl)
Pro IL-1BGeneProductENSG00000125538 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAGEGeneProductENSG00000204305 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RASSF1GeneProductENSG00000068028 (Ensembl)
RASSF2GeneProductENSG00000101265 (Ensembl)
RASSF3GeneProductENSG00000153179 (Ensembl)
RASSF4GeneProductENSG00000107551 (Ensembl)
RASSF5GeneProductENSG00000266094 (Ensembl)
RASSF6GeneProductENSG00000169435 (Ensembl)
RASSF7GeneProductENSG00000099849 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RNSMetaboliteQ225595 (Wikidata)
ROSMetaboliteCHEBI:70982 (ChEBI)
RSKGeneProductENSG00000160469 (Ensembl)
S6GeneProductENSG00000137154 (Ensembl)
S6KGeneProductENSG00000071242 (Ensembl)
SAV1GeneProductENSG00000151748 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SETD5GeneProductENSG00000168137 (Ensembl)
SETDB1GeneProductENSG00000143379 (Ensembl)
SFRPGeneProductENSG00000104332 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STATGeneProductENSG00000115415 (Ensembl)
STK38LGeneProduct23012 (Entrez Gene) NDR1/2
STK3GeneProductENSG00000104375 (Ensembl)
TAZGeneProduct25937 (Entrez Gene)
TCFGeneProductENSG00000081059 (Ensembl)
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
TEL2GeneProductENSG00000100726 (Ensembl)
TERTGeneProductENSG00000164362 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
TGFB1GeneProduct7040 (Entrez Gene)
TNIKGeneProductENSG00000154310 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
TryptophanMetaboliteCHEBI:16828 (ChEBI)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
VEGFAGeneProduct7422 (Entrez Gene)
VEGFAGeneProductENSG00000112715 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22339
VEGFBGeneProductENSG00000173511 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22340
VEGFBGeneProductVEGFB (HGNC)
VEGFCGeneProductENSG00000150630 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22341
VEGFCGeneProductVEGFC (HGNC)
VEGFDGeneProductENSG00000165197 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14205
VEGFDGeneProductVEGFD (HGNC)
VEGFGeneProductENSG00000112715 (Ensembl)
VGLL4GeneProductENSG00000144560 (Ensembl)
Wnt signalingPathwayWP428 (WikiPathways)
YAPGeneProductENSG00000137693 (Ensembl)
c-MycGeneProductENSG00000136997 (Ensembl)
c-fosMetaboliteCHEBI:62519 (ChEBI)
c-junGeneProductENSG00000177606 (Ensembl)
fra-1 GeneProductENSG00000175592 (Ensembl)
glucoseMetaboliteCHEBI:17234 (ChEBI)
let-7RnaENSG00000284520 (Ensembl)
p14ARFProteinQ8N726 (Uniprot-TrEMBL)
prostaglandin E2MetaboliteCHEBI:15551 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5087"
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