DYRK1A involvement regarding cell proliferation in brain development (Homo sapiens)

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Retinoblastoma-like protein 1Retinoblastoma-like protein 2Transcription factor E2F4Histone-binding protein RBBP4Protein lin-9 homologProtein lin-37 homologTranscription factor Dp-2Protein lin-54 homologTranscraiption factor E2F5DREAM complexTranscription factor Dp family member 3Transcription factor Dp-1Protein lin-52 homolog2313, 14833Protein lin-52 homologBeta-secretase 1LATS, large tumor suppressor, homolog 2 (Drosophila), isoform CRA_aCyclin-dependent kinase 6Salvador-Warts-Hippo Signalling PathwayE2F geneDual specificity tyrosine-phosphorylation-regulated kinase 1AMuvB TF complexCDK4 proteinmTORC1GSK3B protein101010102101, 91011Casein kinase 1MTORHedgehog signaling pathwayMLST8Zinc finger protein GLI1TSC1AKT1S1RPTORGLI1TSC2DCAF7DEPTOR2225252CDKN1B proteinDelta-like protein 1Cell CycleG2DLL1HES5Notch Intracellular Domain (NICD)HES1Neurogenin-2QuiescenceSenescenceChemoresistanceCaspase-94Cell cycle exitMSG1G0CDKN1B protein727Cryptochrome-2Protein sprouty homolog 2Delta and Notch-like epidermal growth factor-related receptorCCND1 proteinNAD-dependent protein deacetylase sirtuin-1Amyloid-beta precursor proteinTFAP4Dual specificity tyrosine-phosphorylation-regulated kinase 1AHistone H3Cellular tumor antigen p53NOTCH1Nuclear factor of activated T-cells, cytoplasmic 1GemininDelta-like protein 1TSC1TSC2GSK3B protein10Cryptochrome-2Caspase-92Nuclear factor of activated T-cells, cytoplasmic 12Microtubule-associated protein tauMicrotubule-associated protein tau22 Loss of axonal transport and promotion of tau self-aggregation and fibrillisation2NFAT translocation back to the cytosol,inhibiting NFAT-dependent transcriptionCo-localization of CASP9 to the nucleus;inhibiting apopotic pathway2, 12Cell survival4, 8E2F protein(Neuronal) cell differentiationAmyloid-beta precursor protein Aβ42 and Aβ40 peptides form interlaced amyloid fibrils2Gamma-secretase Histone H32


Description

DYRK1A

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Ontology Terms

 

Bibliography

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  1. Kageyama R, Ohtsuka T, Shimojo H, Imayoshi I; ''Dynamic regulation of Notch signaling in neural progenitor cells.''; Curr Opin Cell Biol, 2009 PubMed Europe PMC Scholia
  2. Kim JE, Finlay GJ, Baguley BC; ''The role of the hippo pathway in melanocytes and melanoma.''; Front Oncol, 2013 PubMed Europe PMC Scholia
  3. Wikipedia contributors; ''DREAM complex''; Wikipedia, The Free Encyclopedia. Retrieved 12:18, February 17, 2022, from https://en.wikipedia.org/w/index.php?title=DREAM_complex&oldid=1064901567, 2022, January 10
  4. Abbassi R, Johns TG, Kassiou M, Munoz L; ''DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications.''; Pharmacol Ther, 2015 PubMed Europe PMC Scholia
  5. Guo X, Williams JG, Schug TT, Li X; ''DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  6. Murakami N, Xie W, Lu RC, Chen-Hwang MC, Wieraszko A, Hwang YW; ''Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  7. Skurat AV, Dietrich AD; ''Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  8. Dick FA, Mymryk JS; ''Sweet DREAMs for Hippo.''; Genes Dev, 2011 PubMed Europe PMC Scholia
  9. Yang EJ, Ahn YS, Chung KC; ''Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  10. Huang Y, Chen-Hwang MC, Dolios G, Murakami N, Padovan JC, Wang R, Hwang YW; ''Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins.''; Biochemistry, 2004 PubMed Europe PMC Scholia
  11. Larsen LJ, Møller LB; ''''; , PubMed Europe PMC Scholia
  12. Bescond M, Rahmani Z; ''Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.''; Int J Biochem Cell Biol, 2005 PubMed Europe PMC Scholia
  13. Fernández-Martínez P, Zahonero C, Sánchez-Gómez P; ''DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis.''; Mol Cell Oncol, 2015 PubMed Europe PMC Scholia
  14. Mao J, Maye P, Kogerman P, Tejedor FJ, Toftgard R, Xie W, Wu G, Wu D; ''Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  15. Woods YL, Rena G, Morrice N, Barthel A, Becker W, Guo S, Unterman TG, Cohen P; ''The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.''; Biochem J, 2001 PubMed Europe PMC Scholia
  16. ''''; , PubMed Europe PMC Scholia
  17. Abbassi R, Johns TG, Kassiou M, Munoz L; ''DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications.''; Pharmacol Ther, 2015 PubMed Europe PMC Scholia
  18. Kang JE, Choi SA, Park JB, Chung KC; ''Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells.''; J Neurosci Res, 2005 PubMed Europe PMC Scholia
  19. Knippschild U, Krüger M, Richter J, Xu P, García-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J; ''The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.''; Front Oncol, 2014 PubMed Europe PMC Scholia
  20. Kinstrie R, Lochhead PA, Sibbet G, Morrice N, Cleghon V; ''dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.''; Biochem J, 2006 PubMed Europe PMC Scholia
  21. Miyata Y, Nishida E; ''DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  22. Lepagnol-Bestel AM, Zvara A, Maussion G, Quignon F, Ngimbous B, Ramoz N, Imbeaud S, Loe-Mie Y, Benihoud K, Agier N, Salin PA, Cardona A, Khung-Savatovsky S, Kallunki P, Delabar JM, Puskas LG, Delacroix H, Aggerbeck L, Delezoide AL, Delattre O, Gorwood P, Moalic JM, Simonneau M; ''DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.''; Hum Mol Genet, 2009 PubMed Europe PMC Scholia
  23. Gu L, Guo Z; ''Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils.''; J Neurochem, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126955view14:19, 7 July 2023DdiglesOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
126860view04:33, 28 June 2023EgonwSet the data source for the Complex Portal identifier
125980view16:10, 23 March 2023DeSlchanged "complex titles" to textLabels as well
125979view16:07, 23 March 2023DeSlConverted unknowns to textLabels
125978view16:04, 23 March 2023DeSlUpdated title
125328view22:20, 31 January 2023LarsgwFix references
122423view22:28, 1 April 2022AlexanderPicoSwitched back to GeneProducts. Though they represent protein functions, Ensembl IDs are for genes, so the more generic type is correct.
122393view15:28, 28 March 2022PklemmerUpdated data node type of several nodes from gene product to protein
122391view12:55, 28 March 2022PklemmerAdjusted several nodes from 'Data Node' to 'Label' if applicable.

Updated some identifiers from canonical transcript (ENST) to Ensembl gene (ENSG).

Minor layout changes.
122347view17:37, 21 March 2022PklemmerFixed missing connection between interaction and data node.
122346view17:30, 21 March 2022PklemmerUpdated descriptions of several proteins and gene products - replaced non-Ensembl identifiers with Ensembl identifiers for Cytoscape dataset compatibility
122342view11:15, 21 March 2022PklemmerUpdated descriptions of several proteins and gene products - replaced non-Ensembl identifiers with Ensembl identifiers for Cytoscsape dataset compatibility.
122318view19:43, 17 March 2022PklemmerUpdated identifiers for ARIP4, caseein kinase 1 alpha 1, Dynamin-1.
122134view16:04, 13 March 2022PklemmerAdjusted 'Biological type' of several nodes from generic 'Gene product' to 'Protein'
122091view18:00, 10 March 2022PklemmerAdded EIF2B interaction

Added to CREB1 interaction

Minor layout changes
122072view19:55, 9 March 2022PklemmerModified description
122071view19:44, 9 March 2022PklemmerAdded SMARCB1 interaction Added REST interaction
121972view17:38, 8 March 2022PklemmerAdded ARIP4 interaction

Added FOXO1 interaction Added Dynamin-1 interaction Added HIP1 interaction Added AMPH1 interaction Added CREB1 interaction

Small layout changes
121508view16:54, 19 February 2022VeerleHorstingEdited APP part
121507view15:27, 19 February 2022VeerleHorstingAdjusted geneproducts to proteins
121500view13:40, 18 February 2022PklemmerIncorporated some changes based on feedback from supervisor.
121464view15:42, 17 February 2022VeerleHorsting
121444view14:05, 17 February 2022VeerleHorstingDREAM complex
121422view11:27, 17 February 2022VeerleHorsting
121421view11:25, 17 February 2022VeerleHorstingReverted to version '20:43, 16 February 2022' by VeerleHorsting
121388view09:35, 17 February 2022VeerleHorstingReverted to version '09:32, 10 February 2022' by VeerleHorsting
121375view20:43, 16 February 2022PklemmerAdded GL1 interaction.

Added DCAF7 interaction. Added mTORC1 interaction. Added Hh interaction.

Added TSC1 and TSC2 interaction.
121343view15:10, 15 February 2022PklemmerUpdated layout. Added references to interactions instead of gene products.
121312view17:46, 14 February 2022PklemmerOntology Term : 'microcephaly' added !
121311view17:43, 14 February 2022PklemmerOntology Term : 'Lewy body dementia' added !
121310view17:43, 14 February 2022PklemmerOntology Term : 'Parkinson's disease' added !
121309view17:43, 14 February 2022PklemmerOntology Term : 'Alzheimer's disease' added !
121308view17:43, 14 February 2022PklemmerOntology Term : 'Down syndrome' added !
121307view17:43, 14 February 2022PklemmerOntology Term : 'intellectual disability' added !
121306view17:41, 14 February 2022PklemmerModified title
121157view09:32, 10 February 2022VeerleHorstingNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Aβ42 and Aβ40 peptides form interlaced amyloid fibrilsQ37028176 (Wikidata)
Loss of axonal transport and promotion of tau self-aggregation and fibrillisation
(Neuronal) cell differentiation
AKT1S1GeneProductENSG00000204673 (Ensembl)
Amyloid-beta precursor protein ProteinP05067 (Uniprot-TrEMBL) Located on chromosome 21
Beta-secretase 1ProteinP56817 (Uniprot-TrEMBL)
CCND1 proteinProteinQ6FI00 (Uniprot-TrEMBL) Cyclin D1
CDK4 proteinProteinQ96BE9 (Uniprot-TrEMBL)
CDKN1B proteinProteinQ6I9V6 (Uniprot-TrEMBL) =p27Kip1

Promotes exit of cell cylce; prevents progression through G1 checkpoint;

Earlier differentiation
Casein kinase 1Protein
Caspase-9ProteinP55211 (Uniprot-TrEMBL)
Cell Cycle
Cell cycle exit
Cell survival
Cellular tumor antigen p53ProteinP04637 (Uniprot-TrEMBL) Not humans
Co-localization of CASP9 to the nucleus; inhibiting apopotic pathway
Cryptochrome-2ProteinQ49AN0 (Uniprot-TrEMBL)
Cyclin-dependent kinase 6ProteinQ00534 (Uniprot-TrEMBL)
DCAF7ProteinENSG00000136485 (Ensembl)
  • DCAF7 = AN11 = HAN11 = WDR68
  • binding of DYRK1A to DCAF7 leads to DCAF7 migrating into cell nucleus, where it might induce aberrant gene expresion = could be part of mechanism that induces Down syndrome phenotypes
DEPTORGeneProductENSG00000155792 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DREAM complex
Delta and Notch-like epidermal growth factor-related receptorPathwayQ8NFT8 (Uniprot-TrEMBL)
Delta-like protein 1ProteinO00548 (Uniprot-TrEMBL)
Dual specificity tyrosine-phosphorylation-regulated kinase 1AProteinQ13627 (Uniprot-TrEMBL)
E2F geneGeneProduct
E2F proteinGeneProduct
G0
G1
G2
GLI1GeneProductENSG00000111087 (Ensembl)
GSK3B proteinProteinQ6FI27 (Uniprot-TrEMBL) idk if this is right
Gamma-secretase Protein
GemininProteinO75496 (Uniprot-TrEMBL)
HES1GeneProductENSG00000114315 (Ensembl)
HES5GeneProductENSG00000197921 (Ensembl)
Hedgehog signaling pathwayPathway
  • dyrk1a both positively and negatively regulates hh
  • add reference
Histone H3ProteinB2R4P9 (Uniprot-TrEMBL)
Histone-binding protein RBBP4ProteinQ09028 (Uniprot-TrEMBL)
LATS, large tumor suppressor, homolog 2 (Drosophila), isoform CRA_aProteinA0A024RDM3 (Uniprot-TrEMBL)
M
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
Microtubule-associated protein tauProteinI3L2Z2 (Uniprot-TrEMBL)
Microtubule-associated protein tauProteinP10636 (Uniprot-TrEMBL)
MuvB TF complex
NAD-dependent protein deacetylase sirtuin-1ProteinQ96EB6 (Uniprot-TrEMBL) Not humans
NFAT translocation back to the cytosol, inhibiting NFAT-dependent transcription
NOTCH1GeneProductENSG00000148400 (Ensembl)
Neurogenin-2ProteinQ9H2A3 (Uniprot-TrEMBL)
Notch Intracellular Domain (NICD)
Nuclear factor of activated T-cells, cytoplasmic 1ProteinO95644 (Uniprot-TrEMBL) idk if this is right
Protein lin-37 homologProteinQ96GY3 (Uniprot-TrEMBL)
Protein lin-52 homologProteinQ52LA3 (Uniprot-TrEMBL)
Protein lin-54 homologProteinQ6MZP7 (Uniprot-TrEMBL)
Protein lin-9 homologProteinQ5TKA1 (Uniprot-TrEMBL)
Protein sprouty homolog 2ProteinO43597 (Uniprot-TrEMBL)
Quiescence

Senescence

Chemoresistance
RPTORGeneProductENSG00000141564 (Ensembl)
Retinoblastoma-like protein 1ProteinP28749 (Uniprot-TrEMBL)
Retinoblastoma-like protein 2ProteinQ08999 (Uniprot-TrEMBL)
S
Salvador-Warts-Hippo Signalling PathwayPathway
TFAP4GeneProductENSG00000090447 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
Transcraiption factor E2F5ProteinQ15329 (Uniprot-TrEMBL)
Transcription factor Dp family member 3ProteinQ5H9I0 (Uniprot-TrEMBL)
Transcription factor Dp-1ProteinQ14186 (Uniprot-TrEMBL)
Transcription factor Dp-2ProteinQ14188 (Uniprot-TrEMBL)
Transcription factor E2F4ProteinQ16254 (Uniprot-TrEMBL)
Zinc finger protein GLI1ProteinP08151 (Uniprot-TrEMBL)
mTORC1ComplexR-HSA-377400

Annotated Interactions

No annotated interactions

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