LDL- influence on CD14 and TLR4 (Homo sapiens)

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MonocytenucleusCytoplasmP38 MAPK (11)PI3KAKTCD14CREBIL10TLR4LDL-AP-1NFKBP38 MAPK (12)P38 MAPK (13)P38 MAPK (14)MCP1IL6IL1-betaIL10IL6MCP1IL1-betaIL6IL1-betaIL10MCP1Extracellular media


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Montserrat Estruch, Jose Luis Sanchez-Quesada, Jordi Ordoñez-Llanos, Sonia Benitez; ''Inflammatory intracellular pathways activated by electronegative LDL in monocytes''; Biochim Biophys Acta ., 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127745view11:23, 30 November 2023DeSlConverted elements in nucleus to groups and reconnected them.
127744view11:17, 30 November 2023DeSlChanged last MCP-1 to CCL2
127739view11:15, 30 November 2023DeSlFixed outdated/alias HGNC symbol MCP-1 to CCL2
127738view11:09, 30 November 2023DeSlAdding comments to InterPro IDs
127737view11:03, 30 November 2023DeSlUpdated AKT ID to more general one
127736view10:54, 30 November 2023DeSlConnected unocnnected line to IL10 group
123542view11:47, 3 August 2022DeSlAdded ChEBI ID for LDL-
123478view15:00, 28 July 2022DeSlOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
123477view15:00, 28 July 2022DeSlOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
123476view14:59, 28 July 2022DeSlOntology Term : 'Interleukin-10 signaling pathway' added !
123475view14:59, 28 July 2022DeSlOntology Term : 'interleukin-1 family mediated signaling pathway' added !
123474view14:58, 28 July 2022DeSlOntology Term : 'signaling pathway' added !
123473view14:58, 28 July 2022DeSlOntology Term : 'Interleukin mediated signaling pathway' added !
123472view14:58, 28 July 2022DeSlOntology Term : 'cytokine mediated signaling pathway' added !
123471view14:57, 28 July 2022DeSlOntology Term : 'monocyte' added !
123470view14:57, 28 July 2022DeSlAdded all individual proteins for NFKB complex
123469view14:50, 28 July 2022DeSlAdding individual CREB (like) proteins
123468view14:44, 28 July 2022DeSlAdding phosphorylation of P38 MAPK
123467view14:37, 28 July 2022DeSlAdded Cytokine release visualization
123466view14:36, 28 July 2022DeSlUpdate cytokine visualization
123465view14:35, 28 July 2022DeSlAdded ref and description
123464view14:26, 28 July 2022DeSlAdded MCP1 (aka CCL2) annotation
123463view13:17, 28 July 2022DeSlAdded nucleus, cytoplasm info
123462view13:14, 28 July 2022DeSlAdd monocyte, comment on LDL-
123461view12:38, 28 July 2022DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKTProteinENSG00000142208 (Ensembl)
AP-1ProteinIPR000837 (InterPro)
CD14ProteinP08571 (Uniprot-TrEMBL)
CREBProtein
IL1-betaGeneProductENSG00000125538 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
LDL-MetaboliteHigh content in Cer, Sph, NEFA
MCP1GeneProductP13500 (Uniprot-TrEMBL)
NFKBProtein
P38 MAPK (11)ProteinQ15759 (Uniprot-TrEMBL)
P38 MAPK (12)ProteinP53778 (Uniprot-TrEMBL)
P38 MAPK (13)ProteinO15264 (Uniprot-TrEMBL)
P38 MAPK (14)ProteinQ16539 (Uniprot-TrEMBL)
PI3KProteinIPR000403 (InterPro)
TLR4ProteinO00206 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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