Glucocorticoid biosynthesis (Homo sapiens)

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1121-hydroxylase deficiencyPrimary aldosteronismGlucocorticoid-remediable aldosteronismAKR1D1HSD11B2Cortisol21-DeoxycortisoneCYP21A211-deoxycortisolCYP3A45alpha-Tetrahydrocortisol17alpha-Hydroxyprogesterone5alpha-DihydrocortisolAKR1C4AKR1C24-Pregnene-17alpha,20alpha-diol-3,11-dionePregnanetriolone5beta-pregnane-11beta,17alpha,20alpha,21-tetrol-3-oneSRD5A118-hydroxycortisolCBR15beta-dihydrocortisol5beta-pregnane-11beta,17alpha,20beta,21-tetrol-3-oneTetrahydrocortisolCortisone20beta-Dihydrocortisone5beta-Pregnane-3alpha,17alpha-diol-11,20-dioneAKR1C121-deoxycortisol5beta-pregnane-17alpha,20alpha,21-triol-3,11-dioneTetrahydrocortisone4,5beta-Dihydrocortisone6beta-hydroxycortisol5beta-pregnane-17alpha,20beta,21-triol-3,11-dioneCYP11B1AKR1C320alpha-Dihydrocortisone2-0alpha-hydroxycortisol18-oxo-dihydrocortisolSRD5A220beta-hydroxycortisolCYP11B218-oxo-cortisol17alpha-hydroxy-5beta-Pregnane-3,11,20-trioneHSD11B15beta-Pregnane-17alpha,20alpha-diol-3,11-dione18-oxo-tetrahydrocortisolalpha-cortolonebeta-cortoloneAKR1C4AKR1C2AKR1C3AKR1C1AKR1D1AKR1D1AKR1C4AKR1C2AKR1C3AKR1C1AKR1D1alpha-Cortolbeta-cortolAKR1C4AKR1C2AKR1C3AKR1C1CYP11B1HSD11B2HSD11B1CYP11B2AKR1D1AKR1D1AKR1D1


Description

Glucocorticoid biosynthesis. Data from Bill griffiths.

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Ontology Terms

 

Bibliography

  1. Radomir M Slominski, Robert C Tuckey, Pulak R Manna, Anton M Jetten, Arnold Postlethwaite, Chander Raman, Andrzej T Slominski; ''Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders''; Genes Immun., 2022 PubMed Europe PMC Scholia
  2. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127387view19:58, 27 September 2023Conroy lipidsprotein to gene product for lipidmaps consistency
126881view15:07, 29 June 2023DeSlConnected unconnected line
126880view15:06, 29 June 2023DeSlAdded Rhea ID info in description
125685view11:09, 7 March 2023Conroy lipidsadd IDs to 21-oic acids and more 21-oics
125643view15:11, 6 March 2023Conroy lipidsadd some terminal products with unknown routes
125495view10:34, 20 February 2023LinaSchifferModified description
125450view14:26, 14 February 2023Conroy lipidscorrect typo
124376view09:15, 20 October 2022DeSlAdded a more elaborate description and lit. ref.
124375view09:09, 20 October 2022DeSlchanged width for all interactions missing a Rhea ID
124374view09:06, 20 October 2022DeSlAdded PW node
124371view08:52, 20 October 2022DeSlOntology Term : 'classic metabolic pathway' added !
124369view08:51, 20 October 2022DeSlOntology Term : 'cortisol biosynthetic pathway' added !
124053view09:56, 15 September 2022DeSlUpdated layut of DataNodes, connected unconnected interactions
124052view09:44, 15 September 2022DeSlConverted all GeneProducts to Protein DataNodes
124051view09:43, 15 September 2022DeSlAnnotated CYP21A1 with human ortholog (called CYP21A2).
124050view09:37, 15 September 2022DeSlOntology Term : 'glucocorticoid biosynthetic pathway' added !
123950view11:04, 7 September 2022Conroy lipids
123949view11:03, 7 September 2022Conroy lipids
123948view11:00, 7 September 2022Conroy lipidsfix link
123947view10:49, 7 September 2022Conroy lipidsmove annotations from catalysis to conversion
123913view13:12, 30 August 2022Conroy lipids
123912view13:12, 30 August 2022Conroy lipids
123911view13:11, 30 August 2022Conroy lipidsadd extra lipids and 2 disease pathway branches
123890view20:59, 24 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123889view20:57, 24 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-deoxycortisolMetaboliteLMST02030086 (LIPID MAPS)
17alpha-HydroxyprogesteroneMetaboliteLMST02030161 (LIPID MAPS)
17alpha-hydroxy-5beta-Pregnane-3,11,20-trioneMetaboliteLMST02030291 (LIPID MAPS)
18-hydroxycortisolMetaboliteLMST02030295 (LIPID MAPS)
18-oxo-cortisolMetaboliteLMST02030296 (LIPID MAPS)
18-oxo-dihydrocortisolMetaboliteLMST02030297 (LIPID MAPS)
18-oxo-tetrahydrocortisolMetaboliteLMST02030298 (LIPID MAPS)
2-0alpha-hydroxycortisolMetaboliteLMST02030271 (LIPID MAPS)
20alpha-DihydrocortisoneMetaboliteLMST02030265 (LIPID MAPS)
20beta-DihydrocortisoneMetaboliteLMST02030266 (LIPID MAPS)
20beta-hydroxycortisolMetaboliteLMST02030270 (LIPID MAPS)
21-DeoxycortisoneMetaboliteLMST02030289 (LIPID MAPS)
21-deoxycortisolMetaboliteLMST02030195 (LIPID MAPS)
4,5beta-DihydrocortisoneMetaboliteLMST02030095 (LIPID MAPS)
4-Pregnene-17alpha,20alpha-diol-3,11-dioneMetaboliteLMST02030294 (LIPID MAPS)
5alpha-DihydrocortisolMetaboliteLMST02030272 (LIPID MAPS)
5alpha-TetrahydrocortisolMetaboliteLMST02030200 (LIPID MAPS)
5beta-Pregnane-17alpha,20alpha-diol-3,11-dioneMetaboliteLMST02030293 (LIPID MAPS)
5beta-Pregnane-3alpha,17alpha-diol-11,20-dioneMetaboliteLMST02030292 (LIPID MAPS)
5beta-dihydrocortisolMetaboliteLMST02030204 (LIPID MAPS)
5beta-pregnane-11beta,17alpha,20alpha,21-tetrol-3-oneMetaboliteLMST02030273 (LIPID MAPS)
5beta-pregnane-11beta,17alpha,20beta,21-tetrol-3-oneMetaboliteLMST02030274 (LIPID MAPS)
5beta-pregnane-17alpha,20alpha,21-triol-3,11-dioneMetaboliteLMST02030267 (LIPID MAPS)
5beta-pregnane-17alpha,20beta,21-triol-3,11-dioneMetaboliteLMST02030268 (LIPID MAPS)
6beta-hydroxycortisolMetaboliteLMST02030269 (LIPID MAPS)
AKR1C1GeneProductQ04828 (Uniprot-TrEMBL)
AKR1C2GeneProductP52895 (Uniprot-TrEMBL)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL)
AKR1C4GeneProductP17516 (Uniprot-TrEMBL)
AKR1D1GeneProductP51857 (Uniprot-TrEMBL)
CBR1GeneProductP16152 (Uniprot-TrEMBL)
CYP11B1GeneProductP15538 (Uniprot-TrEMBL)
CYP11B2GeneProductP19099 (Uniprot-TrEMBL)
CYP21A2ProteinP08686 (Uniprot-TrEMBL) According to UniProt, the original geneName (CYP21A1) is only found in Bovin, Rat, Mouse and Pig. NCBI gene lists a Human ortholog, called: CYP21A2. This is linked to a UniProt entry, which details the reactions this protein catalyzes: " Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:27721825)." Source: [https://www.uniprot.org/uniprotkb/P08686/entry]. This information is also reflected in Rhea.
CYP3A4GeneProductP08684 (Uniprot-TrEMBL)
CortisolMetaboliteLMST02030001 (LIPID MAPS)
CortisoneMetaboliteLMST02030090 (LIPID MAPS)
HSD11B1GeneProductP28845 (Uniprot-TrEMBL)
HSD11B2GeneProductP80365 (Uniprot-TrEMBL)
PregnanetrioloneMetaboliteLMST02030290 (LIPID MAPS)
SRD5A1GeneProductP18405 (Uniprot-TrEMBL)
SRD5A2GeneProductP31213 (Uniprot-TrEMBL)
TetrahydrocortisolMetaboliteLMST02030143 (LIPID MAPS)
TetrahydrocortisoneMetaboliteLMST02030098 (LIPID MAPS)
alpha-CortolMetaboliteLMST02030228 (LIPID MAPS)
alpha-cortoloneMetaboliteLMST02030227 (LIPID MAPS)
beta-cortolMetaboliteLMST02030229 (LIPID MAPS)
beta-cortoloneMetaboliteLMST02030230 (LIPID MAPS)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
11-deoxycortisolCortisolmim-conversion46101 (Rhea)
17alpha-Hydroxyprogesterone11-deoxycortisolmim-conversion50309 (Rhea) EC: 1.14.14.16
Cortisol20beta-hydroxycortisolmim-conversion70216 (Rhea) EC:1.1.1.184
Cortisol5beta-dihydrocortisolmim-conversion46645 (Rhea) EC:1.3.1.3
Cortisol6beta-hydroxycortisolmim-conversion55829 (Rhea) EC:1.14.14.1
CortisolCortisonemim-conversion68618 (Rhea) EC: 1.1.1.146
Cortisolmim-conversion68617 (Rhea)
Cortisone4,5beta-Dihydrocortisonemim-conversion14039 (Rhea) EC:1.3.1.3
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