Axon guidance (Homo sapiens)

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Revision as of 17:39, 8 April 2024

Description

Axon Guidance. Pathway took from KEGG (https://www.kegg.jp/entry/map04360)

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View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

Bibliography

''''; https://www.kegg.jp/entry/map04360,
Goto-Silva L, Martins M, Murillo JR, Souza LRQ, Vitória G, Oliveira JT, Nascimento JM, Loiola EC, Nogueira FCS, Domont GB, Guimarães MZP, Tovar-Moll F, Rehen SK, Junqueira M; ''Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres.''; Biochim Biophys Acta Proteins Proteom, 2021 PubMed Europe PMC Scholia

History

View all...

Revision	Action	Time	User	Comment
129617	view	02:54, 19 May 2024	Eweitz	Improve connectivity, refine colors, economize layout
129605	view	19:33, 18 May 2024	Eweitz	Economize layout
129604	view	17:38, 18 May 2024	Eweitz	Color terminal interactions
129603	view	17:18, 18 May 2024	Eweitz	Improve connectivity, per KEGG source
129602	view	15:59, 18 May 2024	Eweitz	Modified description
129601	view	15:55, 18 May 2024	Eweitz	Modified description
129600	view	15:33, 18 May 2024	Eweitz	Economize layout
129595	view	00:47, 17 May 2024	Eweitz	Specify most phosphorylation interactions, add legend
129592	view	12:42, 16 May 2024	Eweitz	Economize layout
129591	view	12:18, 16 May 2024	Eweitz	Refine content per KEGG source, economize layout
129589	view	03:30, 16 May 2024	Eweitz	Reduce overlapping interactions, economize layout
129588	view	03:19, 16 May 2024	Eweitz	Economize layout
129587	view	03:08, 16 May 2024	Eweitz	Finish diagram rotation / tranposition for easier viewing
129586	view	01:07, 16 May 2024	Eweitz	Continue diagram rotation
129585	view	00:48, 16 May 2024	Eweitz	Continue diagram rotation, refine alignments
129584	view	23:54, 15 May 2024	Eweitz	Begin graphical rotation, for better readability on desktop viewports
129580	view	21:18, 14 May 2024	Eweitz	Economize layout
129573	view	01:15, 14 May 2024	Eweitz	Economize layout
129572	view	22:44, 13 May 2024	Eweitz	Economize layout
129571	view	22:33, 13 May 2024	Eweitz	Economize layout
129446	view	15:59, 20 April 2024	Eweitz	Modified title
129395	view	17:39, 8 April 2024	Khanspers	added KEGG pathway as reference
129394	view	17:38, 8 April 2024	Khanspers	Ontology Term : 'signaling pathway pertinent to the brain and nervous system' added !
129393	view	17:37, 8 April 2024	Khanspers	Ontology Term : 'neuron' added !
129392	view	17:34, 8 April 2024	Khanspers	added xrefs, updated interactions, removed redundant and empty nodes
129389	view	00:36, 6 April 2024	Khanspers	updated interactions to elbows, changed pathway nodes to labels
129388	view	00:21, 6 April 2024	Khanspers	removed fill color for nodes and cell shapes, updated pathway and metabolite nodes
124308	view	16:09, 12 October 2022	LLadeira	Modified title
124307	view	16:06, 12 October 2022	LLadeira	New pathway

External references

DataNodes

View all...

Name	Type	Database reference

ABL1	Protein	ENSG00000097007 (Ensembl)
ABLIM3	Protein	O94929 (Uniprot-TrEMBL)
ARHGEF12	Protein	NM_015313 (RefSeq)
BMP7	Protein	1074 (HGNC Accession number)
BMPR1B	Protein	658 (Entrez Gene)
BMPR2	Protein	659 (Entrez Gene)
BOC	Protein	91653 (Entrez Gene)
CAMK2A	Protein	1460 (HGNC Accession number)
CDC42	Protein	998 (Entrez Gene)
CDK5	Protein	CDK5 (HGNC)
CFL1	Protein	ENSG00000172757 (Ensembl)
CXCL12	Protein	P48061 (Uniprot-TrEMBL)
CXCR4	Protein	NM_001008540 (RefSeq)
Ca2+	Metabolite	CHEBI:29108 (ChEBI)
Cytokine-cytokine receptor interaction	Pathway	hsa04060 (KEGG Pathway)
DCC	Protein	NM_005215 (RefSeq)
DPYSL2	Protein	NM_001386 (RefSeq)
DPYSL5	Protein	Q9BPU6 (Uniprot-TrEMBL)
EFNA1	Protein	1942 (Entrez Gene)
EFNB1	Protein	P98172 (Uniprot-TrEMBL)
ENAH	Protein	NM_018212 (RefSeq)
EPHA2	Protein	EPHA2 (HGNC)
EPHB1	Protein	EPHB1 (HGNC)
FES	Protein	NM_002005 (RefSeq)
FYN	Protein	FYN (HGNC)
FZD3	Protein	FZD3 (HGNC)
GDF7	Protein	GDF7 (HGNC)
GNAI1	Protein	NM_002069 (RefSeq)
GSK3B	Protein	GSK3B (HGNC)
HRAS	Protein	ENSG00000174775 (Ensembl)
ILK	Protein	ENSG00000166333 (Ensembl)
ITGB1	Protein	NM_002211 (RefSeq)
L1CAM	Protein	P32004 (Uniprot-TrEMBL)
LIMK1	Protein	6613 (HGNC Accession number)
LRIG2	Protein	9860 (Entrez Gene)
LRRC4	Protein	15586 (HGNC Accession number)
LRRC4C	Protein	ENSG00000148948 (Ensembl)
MAPK signaling pathway	Pathway	hsa04010 (KEGG Pathway)
MAPK1	Protein	ENSG00000100030 (Ensembl)
MET	Protein	MET (HGNC)
MYL12B	Protein	103910 (Entrez Gene)
NCK1	Protein	ENSG00000158092 (Ensembl)
NCK2	Protein	7665 (HGNC Accession number)
NEO1	Protein	7754 (HGNC Accession number)
NFATC2	Protein	7776 (HGNC Accession number)
NGEF	Protein	Q8N5V2 (Uniprot-TrEMBL)
NRP1	Protein	8829 (Entrez Gene)
NTN1	Protein	8029 (HGNC Accession number)
NTN3	Protein	4917 (Entrez Gene)
NTN4	Protein	59277 (Entrez Gene)
NTNG1	Protein	23319 (HGNC Accession number)
NTNG2	Protein	NM_032536 (RefSeq)
PAK4	Protein	16059 (HGNC Accession number)
PARD3	Protein	PARD3 (HGNC)
PARD6A	Protein	ENSG00000102981 (Ensembl)
PDPK1	Protein	ENSG00000140992 (Ensembl)
PIK3CA	Protein	8975 (HGNC Accession number)
PLCG1	Protein	9065 (HGNC Accession number)
PLXNA1	Protein	ENSG00000114554 (Ensembl)
PLXNB2	Protein	9104 (HGNC Accession number)
PLXNC1	Protein	9106 (HGNC Accession number)
PPP3CA	Protein	9314 (HGNC Accession number)
PRKCA	Protein	PRKCA (HGNC)
PRKCZ	Protein	5590 (Entrez Gene)
PTCH1	Protein	NM_000264 (RefSeq)
PTK2	Protein	9611 (HGNC Accession number)
PTPN11	Protein	9644 (HGNC Accession number)
RAC1	Protein	5879 (Entrez Gene)
RAF1	Protein	ENSG00000132155 (Ensembl)
RASA1	Protein	NM_002890 (RefSeq)
RGMA	Protein	56963 (Entrez Gene)
RGS3	Protein	9999 (HGNC Accession number)
RHOA	Protein	667 (HGNC Accession number)
RHOD	Protein	O00212 (Uniprot-TrEMBL)
RND1	Protein	18314 (HGNC Accession number)
ROBO1	Protein	Q9Y6N7 (Uniprot-TrEMBL)
ROBO2	Protein	NM_001128929 (RefSeq)
ROBO3	Protein	NM_022370 (RefSeq)
ROCK1	Protein	6093 (Entrez Gene)
RRAS	Protein	RRAS (HGNC)
RYK	Protein	ENSG00000163785 (Ensembl)
Regulation of actin cytoskeleton	Pathway	hsa04810 (KEGG Pathway)
SEMA3A	Protein	NM_006080 (RefSeq)
SEMA4F	Protein	10734 (HGNC Accession number)
SEMA5B	Protein	54437 (Entrez Gene)
SEMA6C	Protein	ENSG00000143434 (Ensembl)
SEMA7A	Protein	8482 (Entrez Gene)
SHH	Protein	Q15465 (Uniprot-TrEMBL)
SLIT1	Protein	SLIT1 (HGNC)
SLIT2	Protein	9353 (Entrez Gene)
SLIT3	Protein	SLIT3 (HGNC)
SMO	Protein	11119 (HGNC Accession number)
SRC	Protein	P12931 (Uniprot-TrEMBL)
SRGAP2	Protein	NM_015326 (RefSeq)
TRPC1	Protein	TRPC1 (HGNC)
UNC5D	Protein	Q6UXZ4 (Uniprot-TrEMBL)
WNT4	Protein	ENSG00000162552 (Ensembl)
WNT5A	Protein	WNT5A (HGNC)
Wnt signaling pathway	Pathway	hsa04310 (KEGG Pathway)

Annotated Interactions

No annotated interactions

Axon guidance (Homo sapiens)

From WikiPathways

Revision as of 17:39, 8 April 2024

Description

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Ontology Terms

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History

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Annotated Interactions

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@@ Line 1: / Line 1: @@
 <?xml version="1.0" encoding="UTF-8"?>
 <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Axon Guidance" Organism="Homo sapiens">
-   <Comment/>
+   <Comment></Comment>
    <Comment Source="WikiPathways-description">Axon Guidance. Pathway took from KEGG (https://www.kegg.jp/entry/map04360)</Comment>
    <BiopaxRef>ann1</BiopaxRef>
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+   <Graphics BoardWidth="2622.5" BoardHeight="3362.5" />
    <DataNode TextLabel="Regulation of actin cytoskeleton" GraphId="sa133" Type="Pathway">
-     <Comment/>
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-     <Xref Database="KEGG Pathway" ID="hsa04810"/>
+     <Xref Database="KEGG Pathway" ID="hsa04810" />
    </DataNode>
    <DataNode TextLabel="MAPK signaling pathway" GraphId="sa131" Type="Pathway">
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+     <Xref Database="KEGG Pathway" ID="hsa04010" />
    </DataNode>
    <DataNode TextLabel="DCC" GraphId="sa14" Type="Protein">
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-     <Xref Database="RefSeq" ID="NM_005215"/>
+     <Xref Database="RefSeq" ID="NM_005215" />
    </DataNode>
    <DataNode TextLabel="LRRC4C" GraphId="sa1" Type="Protein">
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-     <Xref Database="Ensembl" ID="ENSG00000148948"/>
+     <Xref Database="Ensembl" ID="ENSG00000148948" />
    </DataNode>
    <DataNode TextLabel="CFL1" GraphId="sa100" Type="Protein">
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-     <Xref Database="Ensembl" ID="ENSG00000172757"/>
+     <Xref Database="Ensembl" ID="ENSG00000172757" />
    </DataNode>
    <DataNode TextLabel="RHOA" GraphId="sa101" Type="Protein">
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-     <Xref Database="HGNC Accession number" ID="667"/>
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    </DataNode>
    <DataNode TextLabel="PLXNA1" GraphId="sa103" Type="Protein">
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-     <Xref Database="Ensembl" ID="ENSG00000114554"/>
+     <Xref Database="Ensembl" ID="ENSG00000114554" />
    </DataNode>
    <DataNode TextLabel="NRP1" GraphId="sa104" Type="Protein">
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-     <Xref Database="Entrez Gene" ID="8829"/>
+     <Xref Database="Entrez Gene" ID="8829" />
    </DataNode>
    <DataNode TextLabel="L1CAM" GraphId="sa105" Type="Protein">
-     <Comment/>
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-     <Xref Database="Uniprot-TrEMBL" ID="P32004"/>
+     <Xref Database="Uniprot-TrEMBL" ID="P32004" />
    </DataNode>
    <DataNode TextLabel="SEMA3A" GraphId="sa106" Type="Protein">
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+     <Graphics CenterX="800.0" CenterY="1880.0" Width="80.0" Height="40.0" ZOrder="26" FontSize="12" Valign="Middle" />
-     <Xref Database="RefSeq" ID="NM_006080"/>
+     <Xref Database="RefSeq" ID="NM_006080" />
    </DataNode>
    <DataNode TextLabel="FES" GraphId="sa107" Type="Protein">
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-     <Xref Database="RefSeq" ID="NM_002005"/>
+     <Xref Database="RefSeq" ID="NM_002005" />
    </DataNode>
    <DataNode TextLabel="FYN" GraphId="sa108" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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-     <Xref Database="HGNC" ID="FYN"/>
+     <Xref Database="HGNC" ID="FYN" />
    </DataNode>
    <DataNode TextLabel="CDK5" GraphId="sa109" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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-     <Xref Database="HGNC" ID="CDK5"/>
+     <Xref Database="HGNC" ID="CDK5" />
    </DataNode>
    <DataNode TextLabel="PLCG1" GraphId="sa11" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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+     <Xref Database="HGNC Accession number" ID="9065" />
    </DataNode>
    <DataNode TextLabel="DPYSL5" GraphId="sa110" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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-     <Xref Database="Uniprot-TrEMBL" ID="Q9BPU6"/>
+     <Xref Database="Uniprot-TrEMBL" ID="Q9BPU6" />
    </DataNode>
    <DataNode TextLabel="DPYSL2" GraphId="sa111" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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-     <Xref Database="RefSeq" ID="NM_001386"/>
+     <Xref Database="RefSeq" ID="NM_001386" />
    </DataNode>
    <DataNode TextLabel="PLXNB2" GraphId="sa113" Type="Protein">
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-     <Xref Database="HGNC Accession number" ID="9104"/>
+     <Xref Database="HGNC Accession number" ID="9104" />
    </DataNode>
    <DataNode TextLabel="SEMA4F" GraphId="sa114" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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+     <Graphics CenterX="747.5" CenterY="2112.5" Width="80.0" Height="40.0" ZOrder="34" FontSize="12" Valign="Middle" />
-     <Xref Database="HGNC Accession number" ID="10734"/>
+     <Xref Database="HGNC Accession number" ID="10734" />
    </DataNode>
    <DataNode TextLabel="SEMA5B" GraphId="sa115" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
-     <Graphics CenterX="750.0" CenterY="2165.0" Width="80.0" Height="40.0" ZOrder="35" FontSize="12" Valign="Middle"/>
+     <Graphics CenterX="750.0" CenterY="2165.0" Width="80.0" Height="40.0" ZOrder="35" FontSize="12" Valign="Middle" />
-     <Xref Database="Entrez Gene" ID="54437"/>
+     <Xref Database="Entrez Gene" ID="54437" />
    </DataNode>
    <DataNode TextLabel="SEMA6C" GraphId="sa116" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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+     <Graphics CenterX="750.0" CenterY="2205.0" Width="80.0" Height="40.0" ZOrder="36" FontSize="12" Valign="Middle" />
-     <Xref Database="Ensembl" ID="ENSG00000143434"/>
+     <Xref Database="Ensembl" ID="ENSG00000143434" />
    </DataNode>
    <DataNode TextLabel="SEMA7A" GraphId="sa117" Type="Protein">
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+     <Comment></Comment>
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+     <Graphics CenterX="747.5" CenterY="2292.5" Width="80.0" Height="40.0" ZOrder="37" FontSize="12" Valign="Middle" />
-     <Xref Database="Entrez Gene" ID="8482"/>
+     <Xref Database="Entrez Gene" ID="8482" />
    </DataNode>
    <DataNode TextLabel="MET" GraphId="sa118" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
-     <Graphics CenterX="957.5" CenterY="2152.5" Width="80.0" Height="40.0" ZOrder="38" FontSize="12" Valign="Middle"/>
+     <Graphics CenterX="957.5" CenterY="2152.5" Width="80.0" Height="40.0" ZOrder="38" FontSize="12" Valign="Middle" />
-     <Xref Database="HGNC" ID="MET"/>
+     <Xref Database="HGNC" ID="MET" />
    </DataNode>
    <DataNode TextLabel="PLXNC1" GraphId="sa119" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
-     <Graphics CenterX="957.5" CenterY="2262.5" Width="80.0" Height="40.0" ZOrder="39" FontSize="12" Valign="Middle"/>
+     <Graphics CenterX="957.5" CenterY="2262.5" Width="80.0" Height="40.0" ZOrder="39" FontSize="12" Valign="Middle" />
-     <Xref Database="HGNC Accession number" ID="9106"/>
+     <Xref Database="HGNC Accession number" ID="9106" />
    </DataNode>
    <DataNode TextLabel="PTK2" GraphId="sa12" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
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+     <Graphics CenterX="1096.5" CenterY="553.5" Width="80.0" Height="40.0" ZOrder="40" FontSize="12" Valign="Middle" />
-     <Xref Database="HGNC Accession number" ID="9611"/>
+     <Xref Database="HGNC Accession number" ID="9611" />
    </DataNode>
    <DataNode TextLabel="ITGB1" GraphId="sa120" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
-     <Graphics CenterX="957.5" CenterY="2322.5" Width="80.0" Height="40.0" ZOrder="41" FontSize="12" Valign="Middle"/>
+     <Graphics CenterX="957.5" CenterY="2322.5" Width="80.0" Height="40.0" ZOrder="41" FontSize="12" Valign="Middle" />
-     <Xref Database="RefSeq" ID="NM_002211"/>
+     <Xref Database="RefSeq" ID="NM_002211" />
    </DataNode>
    <DataNode TextLabel="PTK2" GraphId="sa121" Type="Protein">
-     <Comment/>
+     <Comment></Comment>
-     <Graphics CenterX="1127.5" CenterY="2322.5" Width="80.0" Height="40.0" ZOrder="42" FontSize="12" Valign="Middle"/>
+     <Graphics CenterX="1127.5" CenterY="2322.5" Width="80.0" Height="40.0" ZOrder="42" FontSize="12" Valign="Middle" />
-     <Xref Database="HGNC Accession number" ID="9611"/>
+     <Xref Database="HGNC Accession number" ID="9611" />
    </DataNode>
    <DataNode TextLabel="RAC1" GraphId="sa122" Type="Protein">
-     <Comment/>
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    <Biopax>
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+      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">signaling pathway pertinent to the brain and nervous system</bp:TERM>
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+      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+    </bp:openControlledVocabulary>
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