Notch signaling pathway (Homo sapiens)

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ProteinNotch Signaling PathwayProtein - protein dissociationGATA3MAML1CDKN1APTCRANOTCH1NOTCH2NOTCH4NOTCH3NOTCH1NOTCH2NOTCH4NOTCH3PMNUMAML2CCND1APH1BAPH1ANCSTNPSENENPSEN2PSEN1MAML3GSK3BRING1FHL1HDAC2HDAC1HEY1HES5EP300NCOR2NCOR1SPENSNW1DLL4DLL3DLL1JAG2JAG1ADAM17RBPJSAP30CIRFBXW7CUL1SKP1ITCHNUMBTLE1NFKB1PIK3R2PIK3R1LCKMAGEA1AKT1AKT dependentgene expressionMYCMTORJAK2STAT3HES6HES5HES1NUMBLDTX1HIF1ASRCHEY2PHES1HEY2HEY1STAT3CYNUInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageReceptorProteinmRNALigandEnzyme complex


Description

NetPath_3 - Notch signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128032view17:10, 21 January 2024EweitzEconomize layout, refine legend
127899view23:01, 10 January 2024Khanspersupdated mtor xref
126223view06:22, 17 April 2023EgonwLicense is CCZero
120637view21:38, 21 December 2021EweitzRefine case
120636view21:34, 21 December 2021EweitzStandardize font
120582view18:12, 17 December 2021EweitzModified title
117806view14:39, 22 May 2021EweitzModified title
115833view20:38, 17 March 2021EgonwCopied the NetPath paper into the bibliography
115831view20:18, 17 March 2021EgonwModified description
108322view20:55, 6 December 2019L DupuisConverted interactions to graphical lines in legend
107434view06:51, 8 October 2019DeSlModified title
105486view05:43, 8 August 2019KhanspersModified description
105469view05:16, 8 August 2019KhanspersModified description
78592view14:51, 7 January 2015MaintBotadded missing graphIds
70097view18:41, 12 July 2013MaintBotupdating to 2013 schema
47972view14:20, 23 April 2012NetPathModified description
45344view20:24, 7 October 2011KhanspersOntology Term : 'Notch signaling pathway' added !
44599view21:06, 21 September 2011KhanspersAdded category
44598view21:04, 21 September 2011KhanspersModified description
44597view21:03, 21 September 2011KhanspersUpdating content to NetSlim
44114view20:40, 24 August 2011KhanspersReverted to version '23:22, 1 March 2011' by Khanspers
44037view23:23, 22 August 2011KhanspersModified description
44036view23:20, 22 August 2011KhanspersUpdating pathway from NetSlim
41109view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
35651view21:42, 12 February 2010KhanspersModified description
20805view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Delta-Notch NetPath 3]] moved to [[Pathway:WP61]]: Moved to stable identifier
7984view13:46, 7 January 2008MaintBot[[Pathway:Human:Delta-Notch NetPath 3]] moved to [[Pathway:Homo sapiens:Delta-Notch NetPath 3]]: Renaming species
7616view16:04, 18 December 2007MaintBotfixed category names
7212view12:33, 4 November 2007MaintBotAdded categories to GPML
6308view22:17, 22 May 2007A.Pandeygpml file for [[Human:Delta-Notch_NetPath_3]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM17Protein6868 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
APH1AProtein51107 (Entrez Gene)
APH1BProtein83464 (Entrez Gene)
CCND1Rna595 (Entrez Gene)
CDKN1ARna1026 (Entrez Gene)
CIRProtein9541 (Entrez Gene)
CUL1Protein8454 (Entrez Gene)
DLL1Protein28514 (Entrez Gene)
DLL3Protein10683 (Entrez Gene)
DLL4Protein54567 (Entrez Gene)
DTX1Protein1840 (Entrez Gene)
EP300Protein2033 (Entrez Gene)
FBXW7Protein55294 (Entrez Gene)
FHL1Protein2273 (Entrez Gene)
GATA3Rna2625 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HDAC1Protein3065 (Entrez Gene)
HDAC2Protein3066 (Entrez Gene)
HES1Rna3280 (Entrez Gene)
HES5Protein388585 (Entrez Gene)
HES6Protein55502 (Entrez Gene)
HEY1Rna23462 (Entrez Gene)
HEY1Protein3280 (Entrez Gene)
HEY2Protein23493 (Entrez Gene)
HIF1ARna3091 (Entrez Gene)
ITCHProtein83737 (Entrez Gene)
JAG1Protein182 (Entrez Gene)
JAG2Protein3714 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
LCKProtein3932 (Entrez Gene)
MAGEA1Protein4100 (Entrez Gene)
MAML1Protein9794 (Entrez Gene)
MAML2Protein84441 (Entrez Gene)
MAML3Protein55534 (Entrez Gene)
MTORProtein4137 (Entrez Gene)
MYCRna4609 (Entrez Gene)
NCOR1Protein9611 (Entrez Gene)
NCOR2Protein9612 (Entrez Gene)
NCSTNProtein23385 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NOTCH1Protein4851 (Entrez Gene)
NOTCH2Protein4853 (Entrez Gene)
NOTCH3Protein4854 (Entrez Gene)
NOTCH4Protein4855 (Entrez Gene)
NUMBProtein8650 (Entrez Gene)
NUMBLProtein9253 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PSEN1Protein5664 (Entrez Gene)
PSEN2Protein5663 (Entrez Gene)
PSENENProtein55851 (Entrez Gene)
PTCRARna171558 (Entrez Gene)
RBPJProtein3516 (Entrez Gene)
RING1Protein6015 (Entrez Gene)
SAP30Protein8819 (Entrez Gene)
SKP1Protein6500 (Entrez Gene)
SNW1Protein22938 (Entrez Gene)
SPENProtein23013 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
TLE1Protein7088 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP61"
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