Eukaryotic transcription initiation (Pan troglodytes)

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1, 2TFIIERNA polymerase II5TFIIFTFIIA5Steps 5) RNA elongation with CDT phosphorylation53Steps 2) Association of TIFs and RNA polymerase535Steps 1) TBP binds TATA box(recognize surface DNA geometry)TFIIBRNA pol II3TFIIF353Transcription Initiation Factors (TIFs)TFIID3RNA polymerase ISteps 3) DNA melting by association with TFIIH3TFIIHTATA5TFIIDRNA polymerase IIISteps 4) Transcription elongation by NTPsGene Regulatory Proteins(mRNA, snRNPs)3Primary RNA transcript(small stable RNAs)TFIIBTFIIF(large ribosomal RNAs)TATATFIIATATA Box bindingproteinTFIIHdsDNATFIIE53TATA55cell growthGTF2H3TAF12GTF2E1ERCC3TAF6GTF2F2POLR2FGTF2E2POLR1BGTF2H4GTF2BILKLOC100612178POLR2EGTF2A2POLR2GPOLR1DPOLR3EPOLR2KGTF2H1TBPPOLR1APOLR2HERCC2POLR1EGTF2H2POLR3BCCNHPOLR3DPOLR3HCDK7MNAT1POLR2JPOLR2BPOLR2CPOLR2ITAF5TAF13POLR2APOLR3KTAF7


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r41116) with a 92% conversion rate.

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Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117391view10:32, 21 May 2021EweitzModified title
69257view18:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67218view10:22, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
48168view20:29, 9 May 2012MaintBotUpdating from human to fix xrefs
41564view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35526view13:57, 12 February 2010Thomasadded literature
35514view13:49, 12 February 2010ThomasModified description
34293view22:02, 9 December 2009MaintBotAutomatic update of empty xrefs
33597view09:55, 1 December 2009MaintBotRemoved group label
31618view22:17, 13 August 2009MaintBotFixed text labels
30517view21:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNHGeneProduct739351 (Entrez Gene)
CDK7GeneProduct462378 (Entrez Gene)
ERCC2GeneProduct456124 (Entrez Gene)
ERCC3GeneProduct470526 (Entrez Gene)
GTF2A2GeneProduct453483 (Entrez Gene)
GTF2BGeneProduct743356 (Entrez Gene)
GTF2E1GeneProduct
GTF2E2GeneProduct464098 (Entrez Gene)
GTF2F2GeneProduct741868 (Entrez Gene)
GTF2H1GeneProduct748842 (Entrez Gene)
GTF2H2GeneProduct461830 (Entrez Gene)
GTF2H3GeneProduct452352 (Entrez Gene)
GTF2H4GeneProduct462549 (Entrez Gene)
ILKGeneProduct748941 (Entrez Gene)
LOC100612178GeneProduct100612178 (Entrez Gene)
MNAT1GeneProduct452954 (Entrez Gene)
POLR1AGeneProduct459373 (Entrez Gene)
POLR1BGeneProduct459495 (Entrez Gene)
POLR1DGeneProduct
POLR1EGeneProduct747551 (Entrez Gene)
POLR2AGeneProduct454463 (Entrez Gene)
POLR2BGeneProduct461305 (Entrez Gene)
POLR2CGeneProduct454119 (Entrez Gene)
POLR2EGeneProduct456359 (Entrez Gene)
POLR2FGeneProduct458824 (Entrez Gene)
POLR2GGeneProduct740537 (Entrez Gene)
POLR2HGeneProduct471027 (Entrez Gene)
POLR2IGeneProduct746261 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct741257 (Entrez Gene)
POLR3BGeneProduct452201 (Entrez Gene)
POLR3DGeneProduct464043 (Entrez Gene)
POLR3EGeneProduct454351 (Entrez Gene)
POLR3HGeneProduct745514 (Entrez Gene)
POLR3KGeneProduct744386 (Entrez Gene)
TAF12GeneProduct456686 (Entrez Gene)
TAF13GeneProduct738503 (Entrez Gene)
TAF5GeneProduct735428 (Entrez Gene)
TAF6GeneProduct463588 (Entrez Gene)
TAF7GeneProduct471669 (Entrez Gene)
TBPGeneProduct738472 (Entrez Gene)

Annotated Interactions

No annotated interactions
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