Portal:CPTAC/Hallmark/Growth

From WikiPathways

Jump to: navigation, search

In addition to inducing and sustaining positively acting growth-stimulatory signals, cancer cells must also circumvent powerful programs that negatively regulate cell proliferation. Often these are tumor suppressor genes, that are often mutated in cancer cells. Two examples of this are RB and TP53. (Adapted from Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011)

Personal tools