Apoptosis modulation by HSP70 (Bos taurus)

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Annotate nodes Comment: 5 out of 27 DataNodes have a missing external reference. Check DataNode table at the bottom of the page. Please help improve this pathway by annotating gene, protein and metabolite nodes.

Approved version The current version of this pathway was approved for data analysis by Nhung Pham.

Homology Converted Comment: Inferred from another species Revision {{{tag_revision}}} of this pathway has been inferred from another species (tagged by Maintenance bot). Expression error: Unrecognised punctuation character "{"

Ontology Terms

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Bibliography

1. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia
2. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
4. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
6. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
7. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
8. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
AIFM1	GeneProduct	ENSBTAG00000006838 (Ensembl)	Apoptosis Inducing Factor HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131
APAF1	GeneProduct	ENSBTAG00000021661 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317
Apoptosis	Pathway	WP254 (WikiPathways)
BID2	GeneProduct	ENSBTAG00000013988 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:637
CASP2	GeneProduct	ENSBTAG00000018159 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:835
CASP3	GeneProduct	ENSBTAG00000015874 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
CASP6	GeneProduct	ENSBTAG00000012537 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839
CASP7	GeneProduct	ENSBTAG00000006615 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840
CASP8	GeneProduct	ENSBTAG00000015718 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
CASP9	GeneProduct	ENSBTAG00000002472 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842
CYCS	GeneProduct	ENSBTAG00000022613 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205
FADD	GeneProduct	ENSBTAG00000018274 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
FAS	GeneProduct	ENSBTAG00000010785 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355
FASLG	GeneProduct	ENSBTAG00000032808 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117560
HSPA1A	GeneProduct		HomologyConvert: Multiple homologues found: En:ENSBTAG00000025441;En:ENSBTAG00000025441;
MAP3K1	GeneProduct	ENSBTAG00000013790 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAPK10	GeneProduct	ENSBTAG00000020048 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
NF-kB Pathway	Pathway
NFKB1	GeneProduct	ENSBTAG00000020270 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
RIPK1	GeneProduct	ENSBTAG00000006378 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
TNF-alpha	GeneProduct
TNFRSF1A	GeneProduct	ENSBTAG00000004211 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7132

Annotated Interactions