FGF signaling pathway (Danio rerio)

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1DNA / transcriptionmesodermbmp-related1,2 diacylglycerolTranscriptionfgf 3,8,17bMitochondrial Pathway of Apoptosisinhibitorsfgf + other pathwayfgf + NODALDNAendodermother MAPKsfin outgrowth (fgf10)nodal related genesfeed back transcriptionNodalnRASfgf20a#PKC / itpkc#fgf16#usf2fosSP8lcasanova / sox32gbx1snai1b#fgf13laRAFlelk4 / sap1fgf10bcdh1jnk1 / MAPK8egr2bsrfjunbElk-1tbx16fgfrl1a#fgf6brafkRASacreb1amapkapk5sh3gl3SAPK3 / ERK6fgf11#sipfgf18adusp1 / MKP1MNK1 / MKNK1fgf2fgfr1fgf23tak1fgf22#flhsef / il17rdPTP1bspry4gbx2ERK2 / mapk1ntlspry-rp1#mkk4spry2fgfrl1batf7agrb2mkp3 / dusp6fgf20b#etv5bcmycaatf3rasgrf2fgf12#PLC-gamma#il17rd / seffgfr4sos1egr2arps6kalfgf17bets1bjunRaseIF4EBsp1eEF2KmycnSP8egr1pcdh8AP-1gata5nr2f5p38b / MAPK14bmek1lmapkapk2sox17fgf24ptpn11asox32 / caschchfgf8fgf10fgfr3Badtbx6sh3gl2pea3Tpl-2erk5 / MAPK7fgf13fgf7mkk3fgf19#arafsh3glb2sh3glb2snai1afgfr1op2bmp4mek2lets1aSP9fgf17adusp6 / mkp3sh3gl1spry-rp1#fgf3RAF1lfgf5gscMNK2 / MKNK2mosspry2chrdsnai2atf7batf2l#fgf4p38a / MAPK14afgf1fgf21rps6kb1cPLA2fgf14#fgfr2sox17FRS2fgf18bcblrps6ka3aspry4sh3glb1elk3Calciumshcbp1 / shcERK1 / mapk3eIF4EaPPPPPcreb1bP


Fibroblast growth factors, or FGFs, are a family of growth factors, with members involved in angiogenesis, wound healing, embryonic development and various endocrine signaling pathways. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues. Source: Wikipedia (https://en.wikipedia.org/wiki/Fibroblast_growth_factor)


GenMAPP remarks 
# = not represented in Agilent zebrafish 22k oligo set

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Ontology Terms



  1. Krens SF, Corredor-Adamez M, He S, Snaar-Jagalska BE, Spaink HP; ''ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.''; BMC Genomics, 2008 PubMed Europe PMC Scholia


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118460view15:02, 27 May 2021EgonwReplaced the remaining UniGene IDs
118452view14:58, 27 May 2021EgonwFirst batch of UniGene 2 Ensembl ID replacements
106085view11:59, 16 August 2019MaintBotHMDB identifier normalization
101903view16:52, 16 November 2018EgonwRemoved "undefined" as data source.
96462view15:24, 15 March 2018Susan
96461view15:20, 15 March 2018SusanCoverted unconnected lines
95557view19:16, 28 December 2017DeSlRemoved "last modified" item
95556view19:14, 28 December 2017DeSlChanged unconnected line to graphical line.
95478view08:10, 18 December 2017Andraconnected unconnected lines
95442view06:51, 15 December 2017AlexanderPicoremoved duplicate with bad xref
95441view06:45, 15 December 2017MaintBotfixed xref
95428view16:29, 14 December 2017FehrhartUpdated outdated Unigene IDs
95423view15:39, 14 December 2017Fehrhart
87368view09:56, 22 July 2016MaintBotadded missing graphids
84645view20:56, 10 March 2016KhanspersModified description
84644view20:52, 10 March 2016Khanspersupdated xrefs for fgf18
84643view20:51, 10 March 2016KhanspersQuick edit to datanode annotation or property
84642view20:48, 10 March 2016KhanspersQuick edit to datanode annotation or property
84641view20:47, 10 March 2016KhanspersQuick edit to datanode annotation or property
84640view20:40, 10 March 2016KhanspersQuick edit to datanode annotation or property
84639view20:38, 10 March 2016Khanspersoverhaul
84638view20:29, 10 March 2016KhanspersPeriodical save, work in progress
84637view20:04, 10 March 2016KhanspersQuick edit to datanode annotation or property
84636view20:01, 10 March 2016KhanspersQuick edit to datanode annotation or property
84635view20:00, 10 March 2016KhanspersQuick edit to datanode annotation or property
84634view19:58, 10 March 2016Khanspersremoved comment re GenMAPP db
84633view19:51, 10 March 2016KhanspersQuick edit to datanode annotation or property
84632view19:49, 10 March 2016KhanspersQuick edit to datanode annotation or property
84631view19:49, 10 March 2016KhanspersQuick edit to datanode annotation or property
84630view19:46, 10 March 2016KhanspersQuick edit to datanode annotation or property
84491view23:21, 25 February 2016KhanspersQuick edit to datanode annotation or property
71529view19:23, 17 October 2013MaintBotAutomated update of data sources
68663view05:20, 6 July 2013MaintBotUpdated to 2013 gpml schema
67250view10:26, 26 June 2013Christine ChichesterOntology Term : 'fibroblast growth factor signaling pathway' added !
58793view22:45, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40834view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
34855view04:46, 28 January 2010LouskReverted to version '11:15, 9 June 2009' by Lousk
34854view04:45, 28 January 2010LouskReverted to version '03:18, 22 January 2010' by Lousk
34853view04:44, 28 January 2010LouskReverted to version '03:24, 22 January 2010' by Lousk
34852view04:41, 28 January 2010LouskSpecify description
34823view03:24, 22 January 2010Lousklousk_mod
34822view03:18, 22 January 2010LouskPeriodical save, work in progress
34821view01:39, 22 January 2010LouskPeriodical save, work in progress
29888view11:15, 9 June 2009Thomasupdated ensembl references
29183view18:23, 9 April 2009KhanspersChanges pathway name: removed "zebrafish"
21001view11:30, 14 November 2008MaintBot[[Pathway:Danio rerio:FGF Signaling]] moved to [[Pathway:WP152]]: Moved to stable identifier
16293view20:43, 17 June 2008Khanspers[[Pathway:Danio rerio:Dr FGF-signaling]] moved to [[Pathway:Danio rerio:FGF Signaling]]: Removed species code prefix
14273view07:11, 22 May 2008SFGKrensModified categories
14045view08:20, 21 May 2008SFGKrensNew pathway

External references


View all...
NameTypeDatabase referenceComment
BadGeneProduct58100 (Entrez Gene)
CalciumMetaboliteHMDB0000464 (HMDB)
ERK1 / mapk3GeneProduct399480 (Entrez Gene)
ERK2 / mapk1GeneProduct360144 (Entrez Gene)
FRS2GeneProductENSDARG00000037353 (Ensembl)
MNK1 / MKNK1GeneProduct
MNK2 / MKNK2GeneProduct373121 (Entrez Gene)
PKC / itpkc#GeneProduct334077 (Entrez Gene) inositol 1,4,5-trisphosphate 3-kinase C
PLC-gamma#GeneProduct373867 (Entrez Gene)
PTP1bGeneProduct30081 (Entrez Gene)
RAF1lGeneProduct557109 (Entrez Gene) raf1b
SAPK3 / ERK6GeneProduct30681 (Entrez Gene)
SP8GeneProduct321264 (Entrez Gene)
SP8lGeneProduct324931 (Entrez Gene)
SP9GeneProduct405896 (Entrez Gene)
aRAFlGeneProduct403063 (Entrez Gene)
arafGeneProductENSDARG00000054533 (Ensembl)
atf2l#GeneProduct378449 (Entrez Gene)
atf3GeneProduct393939 (Entrez Gene)
atf7aGeneProductENSDARG00000011298 (Ensembl)
atf7bGeneProduct568197 (Entrez Gene)
bmp4GeneProduct30612 (Entrez Gene)
brafGeneProduct403065 (Entrez Gene)
cPLA2GeneProductENSDARG00000024546 (Ensembl)
casanova / sox32GeneProduct116990 (Entrez Gene)
cblGeneProductENSDARG00000009958 (Ensembl)
cdh1GeneProduct114424 (Entrez Gene)
chrdGeneProduct30161 (Entrez Gene) alias chd
creb1aGeneProductENSDARG00000053586 (Ensembl)
creb1bGeneProductENSDARG00000093420 (Ensembl)
dusp1 / MKP1GeneProduct406340 (Entrez Gene)
dusp6 / mkp3GeneProduct353314 (Entrez Gene)
eEF2KGeneProduct437013 (Entrez Gene)
eIF4EBGeneProduct30738 (Entrez Gene)
eIF4EaGeneProduct79380 (Entrez Gene)
egr1GeneProduct30498 (Entrez Gene)
egr2aGeneProduct368241 (Entrez Gene)
egr2bGeneProduct30190 (Entrez Gene)
elk3GeneProductENSDARG00000077092 (Ensembl)
elk4 / sap1GeneProductENSDARG00000077092 (Ensembl)
erk5 / MAPK7GeneProduct541323 (Entrez Gene)
ets1aGeneProduct280651 (Entrez Gene)
ets1bGeneProductENSDARG00000053868 (Ensembl)
etv5bGeneProductENSDARG00000044511 (Ensembl)
fgf10GeneProduct359830 (Entrez Gene)
fgf10bGeneProductZDB-GENE-060828-1 (ZFIN)
fgf11#GeneProduct497640 (Entrez Gene)
fgf12#GeneProduct497641 (Entrez Gene)
fgf13GeneProduct492758 (Entrez Gene)
fgf1GeneProduct393733 (Entrez Gene)
fgf13lGeneProduct403003 (Entrez Gene)
fgf14#GeneProduct497642 (Entrez Gene)
fgf16#GeneProduct692065 (Entrez Gene)
fgf17aGeneProduct65089 (Entrez Gene)
fgf17bGeneProduct407737 (Entrez Gene)
fgf18aGeneProductENSDARG00000088048 (Ensembl)
fgf18bGeneProductENSDARG00000043962 (Ensembl)
fgf19#GeneProduct368245 (Entrez Gene)
fgf20a#GeneProduct559630 (Entrez Gene)
fgf20b#GeneProduct564770 (Entrez Gene)
fgf21GeneProductENSDARG00000100846 (Ensembl)
fgf22#GeneProduct556999 (Entrez Gene)
fgf23GeneProduct494456 (Entrez Gene)
fgf24GeneProduct359831 (Entrez Gene)
fgf2GeneProductENSDARG00000075031 (Ensembl)
fgf3GeneProduct30549 (Entrez Gene)
fgf4GeneProduct60311 (Entrez Gene)
fgf5GeneProduct494454 (Entrez Gene)
fgf6GeneProduct30560 (Entrez Gene)
fgf7GeneProduct493181 (Entrez Gene)
fgf8GeneProduct30538 (Entrez Gene)
fgfr1GeneProduct30705 (Entrez Gene)
fgfr1op2GeneProduct335511 (Entrez Gene)
fgfr2GeneProductENSDARG00000058115 (Ensembl)
fgfr3GeneProduct58129 (Entrez Gene)
fgfr4GeneProduct30706 (Entrez Gene)
fgfrl1a#GeneProduct393347 (Entrez Gene)
fgfrl1bGeneProduct497135 (Entrez Gene)
flhGeneProduct30260 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
gata5GeneProduct30482 (Entrez Gene)
gbx1GeneProduct142985 (Entrez Gene)
gbx2GeneProduct245948 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
gscGeneProduct30212 (Entrez Gene)
il17rd / sefGeneProduct171474 (Entrez Gene)
jnk1 / MAPK8GeneProduct65236 (Entrez Gene)
junGeneProduct327321 (Entrez Gene)
junbGeneProduct407086 (Entrez Gene)
kRASaGeneProduct393228 (Entrez Gene)
mapkapk2GeneProduct327321 (Entrez Gene)
mapkapk5GeneProduct436608 (Entrez Gene)
mek1lGeneProduct406728 (Entrez Gene)
mek2lGeneProduct563181 (Entrez Gene)
mkk3GeneProduct65239 (Entrez Gene)
mkk4GeneProduct403052 (Entrez Gene)
mkp3 / dusp6GeneProduct353314 (Entrez Gene)
mosGeneProduct402817 (Entrez Gene)
mycnGeneProduct252851 (Entrez Gene)
nRASGeneProduct30380 (Entrez Gene)
nr2f5GeneProduct30427 (Entrez Gene) the original source is Craf (Dr:22) which links to nr2f5 Entrez Gene ID 30427, but craf (name) is recorded as alias for raf1a ID 30716
ntlGeneProduct30399 (Entrez Gene)
p38a / MAPK14aGeneProduct65237 (Entrez Gene)
p38b / MAPK14bGeneProduct266756 (Entrez Gene)
pcdh8GeneProductENSDARG00000006467 (Ensembl)
pea3GeneProductENSDARG00000018303 (Ensembl)
ptpn11aGeneProductENSDARG00000020334 (Ensembl)
rasgrf2GeneProductENSDARG00000002816 (Ensembl)
rps6ka3aGeneProduct338219 (Entrez Gene) Changed from rps6ka3# to rps6ka3a - the original UniGene ID Dr.21039 links now to human olfactory receptor
rps6kalGeneProduct337670 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
sef / il17rdGeneProductENSDARG00000038843 (Ensembl)
sh3gl1GeneProduct378838 (Entrez Gene)
sh3gl2GeneProduct394091 (Entrez Gene)
sh3gl3GeneProduct393150 (Entrez Gene)
sh3glb1GeneProduct334911 (Entrez Gene)
sh3glb2GeneProduct394094 (Entrez Gene)
sh3glb2GeneProduct402885 (Entrez Gene)
shcbp1 / shcGeneProductENSDARG00000102068 (Ensembl)
sipGeneProductENSDARG00000015638 (Ensembl)
snai1aGeneProductENSDARG00000056995 (Ensembl)
snai1b#GeneProduct30182 (Entrez Gene)
snai2GeneProduct494038 (Entrez Gene)
sos1GeneProductENSDARG00000100503 (Ensembl)
sox17GeneProduct30544 (Entrez Gene)
sox32 / casGeneProduct116990 (Entrez Gene)
sp1GeneProductENSDARG00000088347 (Ensembl)
spry-rp1#GeneProduct336135 (Entrez Gene)
spry-rp1#GeneProduct336584 (Entrez Gene)
spry2GeneProduct335098 (Entrez Gene)
spry4GeneProduct114437 (Entrez Gene)
srfGeneProductENSDARG00000053918 (Ensembl)
tak1GeneProduct553788 (Entrez Gene)
tbx16GeneProductENSDARG00000007329 (Ensembl)
tbx6GeneProduct30254 (Entrez Gene)
usf2GeneProductENSDARG00000014463 (Ensembl)

Annotated Interactions

No annotated interactions
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