Biogenic amine synthesis (Danio rerio)

From WikiPathways

Jump to: navigation, search
1Serotonin5-Hydroxy-tryptophanAcetylserotoninPhenylalanineL-DOPACOMTAcetylcholineHistamineGlutamateGABADopamineTyrosineTryptophaneEpinephrineHistidineNorepinephrineMelatoninSynthesis pathways for biogenic amines (in blue)follow solid arrows through enzymatic steps, while degradation steps follow the dashed arrows.CholineHDCaanat1gad1MAOAPNMTachepahCOMTazgc:112198ddcCHATCOMPTbTHMAOAddcDBHASMTtph1ddc


Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Synthesis pathways for biogenic amines (in blue) follow solid arrows through enzymatic steps, while degradation steps follow the dashed arrows. Source:

Try the New WikiPathways

View approved pathways at the new

Quality Tags

Ontology Terms



  1. Purves, Dale, Augustine, George J., Fitzpatrick, David, Katz, Lawrence C., LaMantia, Anthony-Samuel, McNamara, James O., Williams, S. Mark.; ''Neuroscience'';, 2001


View all...
116851view10:47, 14 May 2021EweitzModified title
105102view12:32, 8 July 2019DeSlChanges wikidata ID for ASMT gene
96498view06:46, 16 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96483view16:23, 15 March 2018DeSlOntology Term : 'dopamine degradation pathway' added !
96482view16:22, 15 March 2018DeSlTried to find other gene IDs, but not findable in bridgeDb for species
96478view16:09, 15 March 2018DeSlAdded wikidata as database source where applicable
96477view16:07, 15 March 2018DeSlAdded last IDs needed to annotate full PW.
96469view15:48, 15 March 2018DeSlModified description
96467view15:47, 15 March 2018DeSlAnnotated all metabolites.
96464view15:27, 15 March 2018DeSlRemoved "last modified" item
96463view15:26, 15 March 2018DeSlConnected enzymes to arrows, changed arrows to MIM-conversion, changed layout slightly.
89464view13:14, 15 September 2016Mkutmonremove space in ontology term id
77401view22:34, 5 September 2014MaintBotremoved homology mapp label
71530view19:23, 17 October 2013MaintBotAutomated update of data sources
70075view09:18, 12 July 2013Mkutmonfixed unconnected lines
67085view10:04, 26 June 2013Christine ChichesterOntology Term : 'biogenic amine biosynthetic pathway' added !
62806view19:20, 2 May 2013EgonwConverted many labels into Metabolite DataNodes.
62805view19:13, 2 May 2013EgonwConnected dots.
40837view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35161view14:39, 11 February 2010ThomasModified description
35160view14:39, 11 February 2010Thomasadded literature
34220view21:34, 9 December 2009MaintBotAutomatic update of empty xrefs
21005view11:30, 14 November 2008MaintBot[[Pathway:Danio rerio:Biogenic Amine Synthesis]] moved to [[Pathway:WP154]]: Moved to stable identifier
12040view08:45, 15 May 2008MaintBotAdded to category $category
12038view08:45, 15 May 2008AlexanderPicoUploaded new pathway

External references


View all...
NameTypeDatabase referenceComment
5-Hydroxy-tryptophanMetaboliteCHEBI:17780 (ChEBI)
ASMTGeneProductENSDARG00000098249 (Ensembl)
AcetylcholineMetaboliteCHEBI:15355 (ChEBI)
AcetylserotoninMetaboliteQ4847704 (Wikidata)
CHATGeneProduct100170938 (Entrez Gene)
COMPTbGeneProductENSDARG00000078918 (Ensembl)
COMTaGeneProductENSDARG00000015337 (Ensembl)
CholineMetaboliteCHEBI:15354 (ChEBI)
DBHGeneProduct30505 (Entrez Gene)
DopamineMetaboliteCHEBI:18243 (ChEBI)
EpinephrineMetaboliteQ132621 (Wikidata)
GABAMetaboliteQ210021 (Wikidata)
GlutamateMetaboliteCHEBI:14321 (ChEBI)
HDCGeneProduct793609 (Entrez Gene)
HistamineMetaboliteCHEBI:58432 (ChEBI)
HistidineMetaboliteCHEBI:27570 (ChEBI)
L-DOPAMetaboliteCHEBI:15765 (ChEBI)
MelatoninMetaboliteCHEBI:16796 (ChEBI)
NorepinephrineMetaboliteCHEBI:33569 (ChEBI)
PNMTGeneProductNot in BridgeDb?!
PhenylalanineMetaboliteCHEBI:17295 (ChEBI)
SerotoninMetaboliteCHEBI:28790 (ChEBI)
THGeneProduct30384 (Entrez Gene)
TryptophaneMetaboliteCHEBI:27897 (ChEBI)
TyrosineMetaboliteCHEBI:18186 (ChEBI)
aanat1GeneProduct393677 (Entrez Gene)
acheGeneProduct114549 (Entrez Gene)
ddcGeneProduct406651 (Entrez Gene)
gad1GeneProduct378441 (Entrez Gene)
pahGeneProduct378962 (Entrez Gene)
tph1GeneProduct352943 (Entrez Gene)
zgc:112198GeneProduct550403 (Entrez Gene)

Annotated Interactions

No annotated interactions

Personal tools