Integrated breast cancer pathway (Homo sapiens)

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723205422171025141712312171916171121196179241518MBASC ComplexG2Cell CycleSG18, 13, 16XRCC3SMEK1PLK3RASGEF1ANCOA2TFPIANDRCIP1UBE2FNocodazoleMIR29B1STAT1ESR1CDK4AHRMYCfra-1Anti-ApoptosisCHK2FulvestrantPHBATF1PPRB/RBIRS1MRE11MSH2TGFR2Cell proliferationE2F1KRASUBP16Tetradecanoylphorbol AcetateRAD51HDAC1/HDAC2CTNB1PIAS1CASP3HIPK2HDAC1NFKB1GRNDonepezilSMEK2JAK1ATRRAD50CCND1TSC2BMPR1ASMAD6STK11SIRT1DihydrotestosteroneP85ACDK7Cell Cycle arrestRRASRHOUBP15AURKAAnastrozoleALKB1Cancer DevelopmentMIR21Methyl MethanesulfonatePKCB1AKT1IKKAProteinQ8NBS1DNAMDM2CHK1DHTBAXHydroxyureaP38SMAD7DAG1UBP21BADLapatnibP13KP53Proliferative genesPLK3CAWEE1AQP73BARD1CycloheximideRAD54LMIR21FlutamideP53SMAD1AngiogenesisAKT1PTENPenicillin GGene ExpressionMitomycinGRHydrocortisoneRASGRP3NAB1RPP38CDC25APLK1CERKBAKSMAD4ZN655TamoxifenPPARMDM2RHOCBPMAXERMMP1GDISMAD2RALATAB1PRExemstaneTestosteroneMAPKsRALGAPA1MYT1BRAFTGFR1ERAL1ARCYP19A1MIR21IPKACREBPMLSMAD4ANXA1UBP21ATMEstradiolFLIP1JUNFluoxymesteroneCASP8cyc-DRAFRRASERKBADSP1BRCA1GADD45ABACH1CDK2RAC1MAP3K13PlicamycinRAP1AFADDWEE1ATRMYCEGFRFOXO1RRASZN655CASP3TSC1RaloxifeneHDAC1VEGFAFADDZMIZ1ZN655ABC3GIKKACell SurvivalSMEK1MPIP1DexamethasoneE2F1SMAD3GCRBIDCell survival and ProliferationEP300TSC1TRADDTAK1LSELKTCF/LEFPaclitaxelBRCA1ApoptosisABL1NF1TranscriptionRHEBCDC42LetrozoleCTNB1 degradationSMCA4IMPA1NCOA3ATMCDH1ODC1PAK1BARD1GSK3ADCAKDNOXA1BCL2JKIP1AmpicillinITPKCCERK1ProteasomeMTORP85BMPR2CSNK1DBRCA2MSH6CDK2ApoptosisP13BleomycinUBIMMPIP2FOSL2CASP9BLMJUNSMAD7CERK1CorticosteroneLithium ChlorideATRConjugated Estrogens26MIR29B2


Description

This pathway incorporates the most important proteins for breast cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in breast cancer. These proteins were then used to determine the most important pathways involved in breast cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for breast cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

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  2. Franklin RA, Tordai A, Patel H, Gardner AM, Johnson GL, Gelfand EW; ''Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.''; J Clin Invest, 1994 PubMed Europe PMC Scholia
  3. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  4. Taplin ME, Bubley GJ, Ko YJ, Small EJ, Upton M, Rajeshkumar B, Balk SP; ''Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  5. Wang ZX, Lu BB, Wang H, Cheng ZX, Yin YM; ''MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN.''; Arch Med Res, 2011 PubMed Europe PMC Scholia
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  12. Zhang M, Lee CH, Luo DD, Krupa A, Fraser D, Phillips A; ''Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  13. Paci C, Gobbato R, Carboni T, Sanguigni S, Santone A, Curatola L; ''P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia.''; Neurol Sci, 2006 PubMed Europe PMC Scholia
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  16. Gu RG, Zhou CW, Ma QZ; ''[Effect of dihydrotestosterone on the transcriptions and expressions of Smad3 and Smad4 in LNCaP cell line].''; Zhonghua Nan Ke Xue, 2006 PubMed Europe PMC Scholia
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  21. Terasaki M, Reese TS; ''Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface.''; Cell Motil Cytoskeleton, 1994 PubMed Europe PMC Scholia
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  26. Ellis D, Sothi TD, Avner ED; ''Glucocorticoids modulate renal glucocorticoid receptors and Na-K ATPase activity.''; Kidney Int, 1987 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126476view20:57, 5 May 2023EgonwAdded an identifier for the proteasome node
123531view06:33, 2 August 2022EgonwMade two pathways clickable
116548view12:47, 7 May 2021EweitzModified title
116285view21:46, 26 April 2021EweitzModified description
113594view09:46, 4 November 2020DeSlUpdated hydrocortisone ID (to drug ID).
110683view13:17, 28 May 2020EgonwAdded missing @Type annotation
108807view15:48, 30 January 2020DeSlReplaced P65 with MAP3K13
108804view15:38, 30 January 2020DeSlUpdated C9JNK1 to ZN655
108802view15:27, 30 January 2020DeSlRemoved B5MEC1; doesn't exist in original database anymore; no replacement; no lit.ref.
108799view15:00, 30 January 2020DeSlUpdated name FOSL2
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
ATF1ProteinP18846 (Uniprot-TrEMBL)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl)
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
AngiogenesisPathwayWP1993 (WikiPathways) Example of Angiogenesis PW (homo sapiens)
Anti-ApoptosisPathway
ApoptosisPathway
ApoptosisPathwayWP254 (WikiPathways) Example Pw for apoptosis (homo sapiens)
BACH1ProteinO14867 (Uniprot-TrEMBL)
BADProteinQ92934 (Uniprot-TrEMBL)
BAKProteinQ16611 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
BleomycinMetabolite456190 (PubChem-compound)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBPGeneProductENSG00000005810 (Ensembl)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
CDK4ProteinP11802 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL) Phosphorylated
CIP1ProteinQ9NPC3 (Uniprot-TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl)
CSNK1DGeneProductENSG00000141551 (Ensembl)
CTNB1 degradationPathway
CTNB1ProteinP35222 (Uniprot-TrEMBL)
CYP19A1GeneProductENSG00000137869 (Ensembl)
Cancer DevelopmentPathway
Cell Cycle arrestPathway
Cell SurvivalPathway
Cell proliferationPathway
Cell survival and ProliferationPathway
Conjugated EstrogensMetabolite
CorticosteroneMetabolite5753 (PubChem-compound)
CycloheximideMetabolite6197 (PubChem-compound)
DAG1GeneProductENSG00000173402 (Ensembl)
DCAKDProteinQ8WVC6 (Uniprot-TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl)
DNAGeneProduct
DexamethasoneMetabolite5743 (PubChem-compound)
DihydrotestosteroneMetaboliteHMDB0002961 (HMDB)
DonepezilMetabolite3152 (PubChem-compound)
E2F1GeneProduct1869 (Entrez Gene)
E2F1ProteinQ01094 (Uniprot-TrEMBL)
EGFRProteinP00533 (Uniprot-TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl)
ERAL1GeneProductENSG00000132591 (Ensembl)
ERKGeneProduct64781 (Entrez Gene)
ERProteinP16591 (Uniprot-TrEMBL)
ESR1GeneProductENSG00000091831 (Ensembl)
EstradiolMetabolite5757 (PubChem-compound)
ExemstaneMetabolite
FADDGeneProductENSG00000168040 (Ensembl)
FADDProteinQ13158 (Uniprot-TrEMBL)
FLIP1ProteinQ7Z7B0 (Uniprot-TrEMBL)
FOSL2ProteinP15408 (Uniprot-TrEMBL) AKA B3KP27
FOXO1GeneProductENSG00000150907 (Ensembl)
FluoxymesteroneMetabolite6205 (Chemspider)
FlutamideMetabolite3397 (PubChem-compound)
FulvestrantMetabolite104741 (PubChem-compound)
GADD45AGeneProductENSG00000116717 (Ensembl)
GCRGeneProductENSG00000113161 (Ensembl)
GDIGeneProduct2664 (Entrez Gene)
GR ProteinP01833 (Uniprot-TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl)
GSK3AProteinP49840 (Uniprot-TrEMBL)
Gene ExpressionPathway
HDAC1Protein
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl)
HDAC1ProteinQ13547 (Uniprot-TrEMBL)
HIPK2ProteinQ9H2X6 (Uniprot-TrEMBL)
HydrocortisoneMetaboliteQ26981430 (Wikidata)
HydroxyureaMetabolite3657 (PubChem-compound)
IKKAProteinO15111 (Uniprot-TrEMBL)
IMPA1GeneProductENSG00000133731 (Ensembl)
IPKAProteinP61925 (Uniprot-TrEMBL)
IRS1GeneProductENSG00000169047 (Ensembl)
ITPKCGeneProductENSG00000086544 (Ensembl)
JAK1ProteinP23458 (Uniprot-TrEMBL)
JKIP1ProteinQ96N16 (Uniprot-TrEMBL)
JUNProtein3725 (Entrez Gene)
JUNGeneProductENSG00000177606 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LapatnibMetabolite208908 (PubChem-compound)
LetrozoleMetabolite3765 (Chemspider)
Lithium ChlorideMetabolite433294 (PubChem-compound)
MAP3K13ProteinO43283 (Uniprot-TrEMBL) AKA P65
MAPKsGeneProduct5594 (Entrez Gene)
MAXProteinP61244 (Uniprot-TrEMBL)
MDM2ProteinQ00987 (Uniprot-TrEMBL)
MIR21RnaENSG00000284190 (Ensembl)
MIR29B1RnaENSG00000283797 (Ensembl)
MIR29B2RnaENSG00000284203 (Ensembl)
MMP1ProteinP03956 (Uniprot-TrEMBL)
MPIP1ProteinP30304 (Uniprot-TrEMBL)
MPIP2 ProteinP30305 (Uniprot-TrEMBL)
MRE11ProteinP49959 (Uniprot-TrEMBL)
MSH2ProteinP43246 (Uniprot-TrEMBL)
MSH6ProteinP52701 (Uniprot-TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl)
MYCProtein4609 (Entrez Gene)
MYCProteinP01106 (Uniprot-TrEMBL)
MYT1ProteinQ01538 (Uniprot-TrEMBL)
Methyl MethanesulfonateMetabolite4156 (PubChem-compound)
MitomycinMetaboliteCHEBI:25357 (ChEBI)
NAB1ProteinQ13506 (Uniprot-TrEMBL)
NCOA2GeneProductENSG00000124151 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NF1ProteinP21359 (Uniprot-TrEMBL)
NFKB1 ProteinP19838 (Uniprot-TrEMBL)
NOXA1ProteinQ86UR1 (Uniprot-TrEMBL)
NocodazoleMetabolite4122 (PubChem-compound)
ODC1Protein4953 (Entrez Gene)
P13KGeneProductENSG00000229882 (Ensembl)
P13ProteinQ9UHV8 (Uniprot-TrEMBL)
P38GeneProduct84640 (Entrez Gene)
P53ProteinP04637 (Uniprot-TrEMBL)
P85AGeneProductENSG00000125450 (Ensembl)
P85ProteinO00459 (Uniprot-TrEMBL)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PHBGeneProductENSG00000167085 (Ensembl)
PIAS1ProteinO75925 (Uniprot-TrEMBL)
PKCB1ProteinQ9ULU4 (Uniprot-TrEMBL)
PLK1ProteinP53350 (Uniprot-TrEMBL)
PLK3CAGeneProduct1263 (Entrez Gene)
PLK3GeneProductENSG00000173846 (Ensembl)
PMLProteinP29590 (Uniprot-TrEMBL)
PPARProtein8061 (Entrez Gene)
PPRB/RBProteinP06400 (Uniprot-TrEMBL)
PRProteinP12270 (Uniprot-TrEMBL)
PTENProteinP60484 (Uniprot-TrEMBL)
PaclitaxelMetabolite10368587 (Chemspider)
Penicillin GMetabolite5693 (Chemspider)
PlicamycinMetabolite457831 (PubChem-compound)
Proliferative genesPathway
ProteasomeUnknownQ14878333 (Wikidata)
ProteinProtein
Q8NBS1ProteinQ8NBS1 (Uniprot-TrEMBL)
RAC1ProteinP63000 (Uniprot-TrEMBL)
RAD50ProteinQ92878 (Uniprot-TrEMBL)
RAD51ProteinQ06609 (Uniprot-TrEMBL)
RAD54LGeneProductENSG00000085999 (Ensembl)
RAFProteinP10398 (Uniprot-TrEMBL)
RALAProteinP11233 (Uniprot-TrEMBL)
RALGAPA1GeneProductENSG00000174373 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RASGEF1AGeneProduct221002 (Entrez Gene)
RASGRP3GeneProductENSG00000152689 (Ensembl)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RHOGeneProduct6010 (Entrez Gene)
RHOGeneProductENSG00000163914 (Ensembl)
RPP38GeneProductENSG00000152464 (Ensembl)
RRASProteinP10301 (Uniprot-TrEMBL)
RaloxifeneMetabolite4859 (Chemspider)
SELKProteinQ9Y6D0 (Uniprot-TrEMBL)
SIRT1ProteinQ96EB6 (Uniprot-TrEMBL)
SMAD1ProteinQ15797 (Uniprot-TrEMBL)
SMAD2ProteinQ15796 (Uniprot-TrEMBL)
SMAD3ProteinQ13485 (Uniprot-TrEMBL)
SMAD4ProteinQ13485 (Uniprot-TrEMBL)
SMAD4ProteinQ15796 (Uniprot-TrEMBL)
SMAD6ProteinO43541 (Uniprot-TrEMBL)
SMAD7ProteinO15105 (Uniprot-TrEMBL)
SMCA4ProteinP51532 (Uniprot-TrEMBL)
SMEK1GeneProductENSG00000100796 (Ensembl)
SMEK2GeneProductENSG00000275052 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
STAT1ProteinP42224 (Uniprot-TrEMBL)
STK11GeneProductENSG00000118046 (Ensembl)
TAB1ProteinQ15750 (Uniprot-TrEMBL)
TAK1LProteinP57077 (Uniprot-TrEMBL)
TCF/LEFProtein
TFPIGeneProductENSG00000003436 (Ensembl)
TGFR1ProteinP36897 (Uniprot-TrEMBL)
TGFR2ProteinP37173 (Uniprot-TrEMBL)
TRADDProteinQ15628 (Uniprot-TrEMBL)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2GeneProductENSG00000103197 (Ensembl)
TamoxifenMetabolite2733526 (PubChem-compound)
TestosteroneMetabolite5791 (Chemspider)
Tetradecanoylphorbol AcetateMetaboliteCHEBI:37537 (ChEBI)
TranscriptionPathway
UBE2FProteinQ969M7 (Uniprot-TrEMBL)
UBIMProteinP35544 (Uniprot-TrEMBL)
UBP15ProteinQ9Y4E8 (Uniprot-TrEMBL)
UBP16ProteinQ9Y5T5 (Uniprot-TrEMBL)
UBP21ProteinQ9UK80 (Uniprot-TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl)
WEE1ProteinP30291 (Uniprot-TrEMBL)
XRCC3GeneProductENSG00000126215 (Ensembl)
ZMIZ1ProteinQ9ULJ6 (Uniprot-TrEMBL)
ZN655ProteinQ8N720 (Uniprot-TrEMBL) AKA C9JNK1
cyc-DProtein
fra-1Protein8061 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1984"
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