Serotonin receptor 2 and STAT3 signaling (Mus musculus)

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5, 82, 6, 9, 11, 13...1, 3, 4, 7, 10...1214Jak2GnaqserotoninStat3Htr2a


Description

This pathway depicts the downstream signaling of serotonin via receptor 2A, resulting in the activation of STAT3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP733(r45035) with a 50% conversion rate.

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Bibliography

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  1. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R; ''Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils.''; Fundam Clin Pharmacol, 1995 PubMed Europe PMC Scholia
  2. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y; ''Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.''; Nat Cell Biol, 2004 PubMed Europe PMC Scholia
  3. Butts DA, Rokhsar DS; ''The information content of spontaneous retinal waves.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  4. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M; ''Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  5. Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D'Souza DN, Garcia F, Battaglia G, Muma NA; ''Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus.''; J Pharmacol Exp Ther, 2003 PubMed Europe PMC Scholia
  6. Hattori R, Maulik N, Otani H, Zhu L, Cordis G, Engelman RM, Siddiqui MA, Das DK; ''Role of STAT3 in ischemic preconditioning.''; J Mol Cell Cardiol, 2001 PubMed Europe PMC Scholia
  7. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM; ''Sexual functioning in depressed outpatients taking mirtazapine.''; Depress Anxiety, 1999 PubMed Europe PMC Scholia
  8. Li Q, Muma NA, Battaglia G, Van de Kar LD; ''Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins.''; Brain Res, 1997 PubMed Europe PMC Scholia
  9. Ni CW, Hsieh HJ, Chao YJ, Wang DL; ''Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.''; Am J Physiol Cell Physiol, 2004 PubMed Europe PMC Scholia
  10. Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia
  11. Flowers LO, Subramaniam PS, Johnson HM; ''A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.''; Oncogene, 2005 PubMed Europe PMC Scholia
  12. Guillet-Deniau I, Burnol AF, Girard J; ''Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  13. Murata S, Usuda N, Okano A, Kobayashi S, Suzuki T; ''Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain.''; Brain Res Mol Brain Res, 2000 PubMed Europe PMC Scholia
  14. Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, Pradayrol L, Fourmy D, Dufresne M, Seva C; ''A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  15. Waris G, Turkson J, Hassanein T, Siddiqui A; ''Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication.''; J Virol, 2005 PubMed Europe PMC Scholia
  16. Lo RK, Wong YH; ''Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  17. Goppelt-Struebe M, Stroebel M; ''Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.''; Naunyn Schmiedebergs Arch Pharmacol, 1997 PubMed Europe PMC Scholia
  18. Dougalis A, Lees G, Ganellin CR; ''The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro.''; Neuropharmacology, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125629view01:57, 6 March 2023AlexanderPicoModified description
117942view10:44, 23 May 2021EweitzModified title
105026view10:42, 29 June 2019EgonwAnother space in a PubMed identifier removed.
105009view07:35, 28 June 2019EgonwRemoved trailing spaces in PubMed identifiers.
104959view12:56, 27 June 2019Fehrhartannotated missing nodes
102082view19:40, 28 November 2018EgonwRemoved whitespace in PubMed identifiers.
74497view15:59, 26 April 2014EgonwFixed PubMed IDs.
69173view18:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
45981view21:01, 1 December 2011MaintBotNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
GnaqGeneProduct14682 (Entrez Gene) guanine nucleotide binding protein, alpha q polypeptide
Htr2aGeneProductENSMUSG00000034997 (Ensembl) 5-hydroxytryptamine (serotonin) receptor 2A
Jak2GeneProductENSMUSG00000024789 (Ensembl) Janus kinase 2
Stat3GeneProduct20848 (Entrez Gene) signal transducer and activator of transcription
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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