BMP signaling pathway (Danio rerio)

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1222binds BMP-2 and BMP-4degradation of Smad1 and Smad5putative Xenopus direct bmp targetsBMP ligandsBMP target genesdanio rerio bmp targetsbinds BMP-2 and BMP-4Gata genes?ZF marker genessmad1bmpr1abdeltaNP63/tp73lacvrl1/violet beauregarde (vbg)snai1abmp1b/tolloidbmpr2prdcdeltaNP63/tp73lsmad4acvr2bgata3hrbsmad4smurf2twsg1afollistatinbmp1a/tolloidbmp5deltaNP63/tp73lbmpr1babmp15bmpr1asmad8snip1pccagata2msx csmad5/somitabun (sbn)noggin2bambibmpr1bbbmpr2msx abmp5bambiNucleoporin like protein RABbmp2bsmad7noggin3bmp1amsx edeltaNP63/tp73lbambigata2bmp2b/swirl(swr)twsg1bfollistatin likegata5bmp1b/tolloidmsx dgoosecoidadmpbmp1bsmurf-1(WWP1)bmp7bmp1lfollistatinbmp4acvr2bid3bmp6kheper/zfhx1gata6Ubiquitin carrier proteinprdcsmad6follistatin-like 1bmp4gremlin 1smad1bmp8gremlin 1msx ebmp2abmpernoggin1bmp5lgata4smad1tbx2abmp7/snailhouse (snh)chordin/dino(din)msx btolloid-like 1/mini fin (mfn)rack1 (gnb2l1)crim1snai2ventdeltaNP63/tp73lcrim1bmp3acvr1/lost a fin (laf)voxtbx2bsmad6asnai1bsmad4rpl15gata1/vlad tepes (vlt)follistatin 2smad6b


Description

The bone morphogenetic protein (BMP) signalling pathway play critical roles in germ layer induction and patterning in early zebrafish embryos. Smad2/3 and Smad1/5/8 are intracellular effectors of BMPs. These Smads regulate, in cooperation with other factors, transcription of hundreds of target genes in the nucleus. The activity and stability of Smads are regulated by phosphorylation modifications.

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Bibliography

  1. Krens SF, Corredor-Adamez M, He S, Snaar-Jagalska BE, Spaink HP; ''ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.''; BMC Genomics, 2008 PubMed Europe PMC Scholia
  2. Liu X, Wang Q, Meng A; ''Detection of Smad Signaling in Zebrafish Embryos.''; Methods Mol Biol, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118479view05:38, 28 May 2021EgonwReplaced UniGene IDs with Ensembl IDs
118478view05:33, 28 May 2021EgonwReplaced UniGene IDs with Ensembl IDs from the comments
111797view15:07, 7 September 2020LaurentFixed interactions
111762view19:04, 5 September 2020EgonwCorrected the data source
109427view08:48, 17 March 2020L DupuisChanged interaction line to graphical line
101827view09:21, 12 November 2018EgonwReplaced old Uniprot data sources with the new ones.
95492view13:07, 18 December 2017DeSlRemoved "last modified" item
95490view12:25, 18 December 2017DeSlModified description
95489view12:21, 18 December 2017DeSlChanged IDs from Dr-database which didn't map to BridgeDB with Uniprot/ensemble.
89465view13:14, 15 September 2016Mkutmonremove space in ontology term id
87369view09:56, 22 July 2016MaintBotadded missing graphids
84689view20:18, 15 March 2016Khanspersconnected interactions and updated xrefs
84688view20:12, 15 March 2016KhanspersPeriodical save, work in progress
84687view20:01, 15 March 2016KhanspersQuick edit to datanode annotation or property
84686view19:59, 15 March 2016Khanspersremoved hash marks
68610view03:50, 6 July 2013MaintBotUpdated to 2013 gpml schema
67097view10:06, 26 June 2013Christine ChichesterOntology Term : 'Bone morphogenetic proteins signaling pathway' added !
58784view22:44, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40771view22:14, 1 March 2011MaintBotRemoved redundant pathway information and comments
29890view11:17, 9 June 2009Thomasupdated ensembl references
29184view18:25, 9 April 2009KhanspersChanges pathway name: removed "zebrafish"
21123view11:30, 14 November 2008MaintBot[[Pathway:Danio rerio:BMP Signaling]] moved to [[Pathway:WP211]]: Moved to stable identifier
16287view20:41, 17 June 2008Khanspers[[Pathway:Danio rerio:Dr BMP-signaling]] moved to [[Pathway:Danio rerio:BMP Signaling]]: Removed species code prefix
15416view23:50, 27 May 2008KhanspersPeriodical save, work in progress
14271view07:10, 22 May 2008SFGKrensModified categories
14043view08:16, 21 May 2008SFGKrensNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Nucleoporin like protein RABGeneProduct393560 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000021158
Ubiquitin carrier proteinGeneProduct565498 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000047452
acvr1/lost a fin (laf)GeneProduct30615 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017977
acvr2bGeneProductENSDARG00000044422 (Ensembl)
acvrl1/violet beauregarde (vbg)GeneProduct266753 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043462
admpGeneProduct140619 (Entrez Gene)
bambiGeneProduct431736 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000078899
bambiGeneProduct83496 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000077732
bmp15GeneProductENSDARG00000037491 (Ensembl)
bmp1a/tolloidGeneProductQ29772966 (Wikidata) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033284
bmp1aGeneProductENSDARG00000069054 (Ensembl)
bmp1b/tolloidGeneProduct335826 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059795
bmp1b/tolloidGeneProduct559877 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059795
bmp1bGeneProduct559877 (Entrez Gene)
bmp1lGeneProduct30204 (Entrez Gene)
bmp2aGeneProduct30631 (Entrez Gene)
bmp2b/swirl(swr)GeneProductO93369 (Uniprot-TrEMBL) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000060734
bmp2bGeneProductO93369 (Uniprot-TrEMBL)
bmp3GeneProduct335252 (Entrez Gene)
bmp4GeneProduct30612 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000075150
bmp5GeneProduct394026 (Entrez Gene)
bmp5lGeneProduct337711 (Entrez Gene)
bmp6GeneProductENSDARG00000015686 (Ensembl)
bmp7GeneProduct
bmp7/snailhouse (snh)GeneProduct30584 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000016472
bmp8GeneProduct378445 (Entrez Gene)
bmperGeneProductENSDARG00000040893 (Ensembl)
bmpr1aGeneProduct58145 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000026768
bmpr1abGeneProductENSDART00000066309 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000066309
bmpr1baGeneProductENSDARG00000104100 (Ensembl)
bmpr1bbGeneProductENSDARG00000075729 (Ensembl)
bmpr2GeneProduct555655 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002334
bmpr2GeneProduct562822 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000056764
chordin/dino(din)GeneProductENSDART00000045110 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000045110
crim1GeneProduct404210 (Entrez Gene)
crim1GeneProductENSDARG00000029668 (Ensembl)
deltaNP63/tp73lGeneProduct260407 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137
deltaNP63/tp73lGeneProduct325581 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065285
deltaNP63/tp73lGeneProduct335185 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137
follistatin 2GeneProductQ2PMI4 (Uniprot-TrEMBL) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000080772
follistatin likeGeneProductENSDART00000080772 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000080772
follistatin-like 1GeneProductENSDARG00000015559 (Ensembl)
follistatinGeneProduct30235 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000051065
follistatinGeneProduct557352 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034851
gata1/vlad tepes (vlt)GeneProductENSDARG00000013477 (Ensembl)
gata2GeneProduct30480 (Entrez Gene)
gata3GeneProduct30458 (Entrez Gene)
gata4GeneProduct30483 (Entrez Gene)
gata5GeneProduct30482 (Entrez Gene)
gata6GeneProduct58076 (Entrez Gene)
goosecoidGeneProductENSDARG00000059073 (Ensembl)
gremlin 1GeneProduct405778 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000076092
hrbGeneProductENSDART00000043960 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043960
id3GeneProduct246093 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000021064
kheper/zfhx1GeneProductENSDART00000047724 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000047724
msx aGeneProduct30528 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017825
msx bGeneProduct30511 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000008486
msx cGeneProduct30526 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014176
msx dGeneProduct30531 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000003441
msx eGeneProduct30527 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002232
msx eGeneProductQ90455 (Uniprot-TrEMBL) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002232
noggin1GeneProductENSDART00000081766 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000081766
noggin2GeneProductENSDART00000063231 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000063231
noggin3GeneProduct30173 (Entrez Gene)
pccaGeneProduct437019 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034097
prdcGeneProduct378455 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024960
prdcGeneProduct550399 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024960
rack1 (gnb2l1)GeneProduct30722 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000061001
rpl15GeneProductENSDARG00000009285 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034837
smad1GeneProduct30628 (Entrez Gene)
smad1GeneProduct323405 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033566
smad4GeneProduct30640 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000035478
smad4GeneProductENSDARG00000023527 (Ensembl)
smad4GeneProductENSDARG00000045094 (Ensembl)
smad5/somitabun (sbn)GeneProduct30641 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000054175
smad6GeneProductENSDARG00000031763 (Ensembl)
smad6aGeneProductENSDARG00000053209 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014508
smad6bGeneProductENSDARG00000031763 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014508
smad7GeneProductENSDARG00000016858 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024277
smad8GeneProductENSDART00000028618 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000028618
smurf-1(WWP1)GeneProductENSDART00000004923 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000004923
smurf2GeneProductENSDARG00000038067 (Ensembl)
snai1aGeneProductENSDARG00000056995 (Ensembl)
snai1bGeneProductENSDARG00000046019 (Ensembl)
snai2GeneProductENSDART00000033566 (Ensembl)
snip1GeneProduct474374 (Entrez Gene)
tbx2aGeneProduct30247 (Entrez Gene)
tbx2bGeneProduct30253 (Entrez Gene)
tolloid-like 1/mini fin (mfn)GeneProduct474335 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000054472
twsg1aGeneProductENSDART00000049963 (Ensembl) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000049963
twsg1bGeneProduct259304 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059299
ventGeneProduct64810 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017456
voxGeneProduct64807 (Entrez Gene) http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000008176

Annotated Interactions

No annotated interactions

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