Colchicine metabolic pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Colchicine3DMC2DMCCYP3A4Name: Colchicine metabolic pathwayOrganism: Homo sapiens


Description

P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : Notch signaling pathway
 

Bibliography

  1. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC Scholia
  2. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117685
Approved
view12:08, 22 May 2021EweitzModified title
92288view12:39, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
74479view07:42, 25 April 2014EgonwFixed the Uniprot ID.
71707view19:59, 17 October 2013MaintBotUpdated data sources
70549view22:27, 10 August 2013EgonwModified description
70548view22:26, 10 August 2013EgonwCholchicine decreases the expression of the CYP that metabolises it.
70542view12:31, 10 August 2013EgonwIndicated the source of the two current conversions.
70518view13:08, 9 August 2013EgonwAdded a related paper, explaining a loop.
70517view13:07, 9 August 2013EgonwSimplified the diagram.
70513view12:41, 9 August 2013EgonwModified description
70512view12:40, 9 August 2013EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
70511view12:38, 9 August 2013EgonwAdded the ChemSpider IDs for 2DMC and 3DMC.
70510view12:35, 9 August 2013EgonwNew pathway

External references

DataNodes

Name  ↓Type  ↓Database reference  ↓Comment  ↓
2DMCMetabolite22210 (Chemspider)
3DMCMetabolite264748 (Chemspider)
CYP3A4ProteinP08684 (Uniprot-TrEMBL)
ColchicineMetabolite5933 (Chemspider)

Annotated Interactions

No annotated interactions

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