Caffeine and theobromine metabolism (Homo sapiens)

Description

Metabolism pathway of two compounds commonly found in human samples: caffeine and theobromine.

View approved pathways at the new wikipathways.org.

Denis M. Grant, Bing K. Tang, Werner Kalow; ''Variability in caffeine metabolism''; Clinical Pharmacology and Therapeutics, 1983 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
123391	view	06:21, 23 July 2022	Egonw	Made a pathway clickable
118462	view	15:03, 27 May 2021	Marvin M2	added pubmed id
117668	view	11:58, 22 May 2021	Eweitz	Modified title
106746	view	13:22, 17 September 2019	MaintBot	HMDB identifier normalization
103686	view	14:37, 28 March 2019	DeSl	Added linkout to Purine PW.
85154	view	12:02, 21 April 2016	MaintBot	Ontology Term : 'caffeine metabolic pathway' added !
85153	view	11:55, 21 April 2016	MaintBot	Ontology Term : 'xenobiotic metabolic pathway' added !
85116	view	10:46, 17 April 2016	Egonw	Added an XMetDB interaction ID.
85115	view	10:38, 17 April 2016	Egonw	Modified description
85114	view	10:37, 17 April 2016	Egonw	Added a reference.
85113	view	10:18, 17 April 2016	Egonw	New pathway

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Name	Type	Database reference
1,7-dimethyluric acid	Metabolite	HMDB0011103 (HMDB)
1-methyluric acid	Metabolite	HMDB0003099 (HMDB)
1-methylxanthine	Metabolite	HMDB0010738 (HMDB)
3,7-dimethyluric acid	Metabolite	HMDB0001982 (HMDB)
7-methyluric acid	Metabolite	HMDB0011107 (HMDB)
7-methylxanthine	Metabolite	HMDB0001991 (HMDB)
AFMU	Metabolite	CHEBI:32643 (ChEBI)
CYP1A2	GeneProduct	ENSG00000140505 (Ensembl)
CYP2A6	GeneProduct	ENSG00000255974 (Ensembl)
NAT2	GeneProduct	ENSG00000156006 (Ensembl)
Purine metabolism	Pathway	WP4224 (WikiPathways)
XDH	GeneProduct	ENSG00000158125 (Ensembl)
Xanthine	Metabolite	HMDB0000292 (HMDB)
caffeine	Metabolite	HMDB0001847 (HMDB)
paraxanthine	Metabolite	HMDB0001860 (HMDB)
theobromine	Metabolite	HMDB0002825 (HMDB)

Source	Target	Type	Database reference	Comment
caffeine	paraxanthine	mim-conversion	XMETDB64 (XMetDB)