Renin-angiotensin system (Rattus norvegicus)

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NucleusEndoplasmic ReticulumDNALegendDNAMetaboliteVasoconstriction, Cellular Proliferation,Hypersecretion of Aldosterone,Myocardial Hypertrophy, Fibrosis and Renal Damage*Not clear if it also exists in ratDNAIPR3 isoformsPAK isoformsVasodilation, Inhibationof Cellular Proliferationand Induction of ApoptosisDNACell membraneJNK isoformsRasPrkcqMKK4IP3Angiotensin IIMEKK1IP3RFosItpr3Angiotensin 1Raf1ERK1AceIkbkgROSAngiotensin (1-5)MmeItpr1MEKK1Grb2PpgbNF-KBSHCPAK1AngiotensinogenMapk3MKK7FAKPIP2CA2+PAK7Mas1PPtaseAce2JNKSTAT1CeramidePtgIRPAK3Itpr2LnpepCpa3AnpepReninElk1p38Agtr1ac-JunAC2/3Angiotensin IIISOSAngiotensin (1-7)PYK2Thop1CTSGGalfaQ/11Angiotensin IVCMA1Agtr2Mapk9MmeNOAngiotensin (1-9)PI3KPlcb1DAGAceNlnMapk8ATF2Jak2PAK2cAMPSTAT3PAKPAK4PAK6EnpepAceAce2TYKRac1PKATYKMapk10Ikbkb38, 42, 44, 56, 61...25, 114164, 17789, 1421, 67, 7230, 134, 16291, 16333, 864713, 22, 26, 32, 55...27, 36, 438, 17, 45, 74, 87...66, 81, 1615, 7, 23, 38, 49...101, 1194, 6, 21, 34, 39...25, 13754, 68, 76, 93, 96...128, 1551264, 6, 21, 34, 39...19, 70, 73, 111, 122...12913452, 1401672, 10, 57, 79, 84...18, 109183, 60, 6292, 94103, 121489, 11, 29, 64, 80...5, 7, 23, 38, 49...14, 20, 34, 46, 63...35, 50, 1737, 11, 82, 117, 131...15, 53, 11228, 42, 58, 70, 78...110, 17224, 34, 40, 41, 71...14, 20, 34, 46, 63...31, 17712637, 51, 100, 105, 111...12, 16, 9591126142, 14911, 99, 15059, 69, 754, 6, 21, 34, 39...ProteinIsoformsHuman proteinGene Product


Description

This pathway is based on the KEGG pathway of renin-angiotensin and the Ambion pathway of renin-angiotensin

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Bibliography

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  134. Ibarz G, Oiry C, Carnazzi E, Crespy P, Escrieut C, Fourmy D, Galleyrand JC, Gagne D, Martinez J; ''Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.''; Br J Pharmacol, 2006 PubMed Europe PMC Scholia
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  137. Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM; ''Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
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  142. Tsai CT, Lai LP, Kuo KT, Hwang JJ, Hsieh CS, Hsu KL, Tseng CD, Tseng YZ, Chiang FT, Lin JL; ''Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.''; Circulation, 2008 PubMed Europe PMC Scholia
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  147. Jeske NA, Berg KA, Cousins JC, Ferro ES, Clarke WP, Glucksman MJ, Roberts JL; ''Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia.''; J Neurochem, 2006 PubMed Europe PMC Scholia
  148. Healy DP, Printz MP; ''Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat.''; Hypertension, 1985 PubMed Europe PMC Scholia
  149. Zhang Y, Zhang H, Yuan X, Gu X; ''Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.''; Pediatr Res, 2007 PubMed Europe PMC Scholia
  150. Lutzelschwab C, Pejler G, Aveskogh M, Hellman L; ''Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations.''; J Exp Med, 1997 PubMed Europe PMC Scholia
  151. Becker LK, Etelvino GM, Walther T, Santos RA, Campagnole-Santos MJ; ''Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  152. Carrera MP, Ramirez-Exposito MJ, Valenzuela MT, Duenas B, Garcia MJ, Mayas MD, Martinez-Martos JM; ''Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.''; Cancer Invest, 2006 PubMed Europe PMC Scholia
  153. Tada M, Fukamizu A, Seo MS, Takahashi S, Murakami K; ''Nucleotide sequence of rat renin cDNA.''; Nucleic Acids Res, 1988 PubMed Europe PMC Scholia
  154. Young D, O'Neill K, Jessell T, Wigler M; ''Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.''; Proc Natl Acad Sci U S A, 1988 PubMed Europe PMC Scholia
  155. Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J; ''Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  156. Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ; ''Molecular cloning and amino acid sequence of rat enkephalinase.''; Biochem Biophys Res Commun, 1987 PubMed Europe PMC Scholia
  157. Stragier B, Demaegdt H, De Bundel D, Smolders I, Sarre S, Vauquelin G, Ebinger G, Michotte Y, Vanderheyden P; ''Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.''; Brain Res, 2007 PubMed Europe PMC Scholia
  158. Langford K, Frenzel K, Martin BM, Bernstein KE; ''The genomic organization of the rat AT1 angiotensin receptor.''; Biochem Biophys Res Commun, 1992 PubMed Europe PMC Scholia
  159. Dauch P, Vincent JP, Checler F; ''Molecular cloning and expression of rat brain endopeptidase 3.4.24.16.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  160. Hamilton TA, Handa RK, Harding JW, Wright JW; ''A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat.''; Peptides, 2001 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
116622view11:06, 9 May 2021EweitzModified title
107611view14:06, 24 October 2019DeSlAdded last missing ID.
107610view14:05, 24 October 2019DeSlUpdated secondary ChEBI ID, added missing IDs to some proteins+metabolites.
107543view19:06, 18 October 2019KhanspersModified description
107542view19:05, 18 October 2019Khanspersadditional cleanup, added legend
107541view18:27, 18 October 2019Khanspersupdated layout, added xrefs
107242view14:34, 17 September 2019MaintBotChEBI identifier normalization
106984view13:44, 17 September 2019MaintBotHMDB identifier normalization
105411view16:06, 7 August 2019DeSlModified description
105410view16:05, 7 August 2019DeSlChanged colours to WPs scheme.
105409view16:02, 7 August 2019DeSlConnected unconnected lines (to groups)
105288view11:40, 28 July 2019EgonwAdded some interaction typing and missing identifiers.
101984view21:12, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
89602view16:08, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89601view16:08, 19 September 2016AgustinGVOntology Term : 'hypertension' added !
89042view19:57, 18 August 2016AgustinGVUpdate available metabolites annotations
88865view17:22, 16 August 2016AgustinGVSpecify description
88864view17:21, 16 August 2016AgustinGVSpecify description
88863view17:17, 16 August 2016AgustinGVUpdate AGT
88862view17:07, 16 August 2016AgustinGVUpdate AGT as protein
88861view17:04, 16 August 2016AgustinGVUpdate AGT Gene ID
88860view16:24, 16 August 2016AgustinGVQuick edit to datanode annotation or property
83030view02:21, 18 November 2015Mkutmonfix issues in reference list
83029view02:07, 18 November 2015Mkutmonfix outdated identifiers
70120view19:23, 12 July 2013MaintBotupdated to 2013 schema
67626view11:35, 26 June 2013DdiglesOntology Term : 'renin-angiotensin cascade pathway' added !
41750view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
34121view19:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32412view17:06, 15 August 2009MaintBotFixed text labels
32069view13:36, 14 August 2009MaintBotFixed group labels
29243view07:40, 18 April 2009EveloSome annotations
21469view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Renin - Angiotensin System]] moved to [[Pathway:WP376]]: Moved to stable identifier
15828view08:19, 5 June 2008Thomaschanged type of Reactive oxygen species (ROS) to metabolite
11563view07:25, 11 April 2008Thomas
11553view17:09, 10 April 2008MarkRenin - Angiotensin System
11548view10:17, 10 April 2008Thomas
11535view07:42, 8 April 2008Markrenin-angiontensin system
11500view09:42, 3 April 2008Thomasremoved special characters from literature references
11491view18:05, 2 April 2008ThomasModified description
11490view17:22, 2 April 2008Mark
11488view13:29, 2 April 2008ThomasReverted edits by [[Special:Contributions/Mark|Mark]] ([[User_talk:Mark|Talk]]); changed back to last version by [[User:Thomas|Thomas]]
11487view13:24, 2 April 2008MarkRenin - Angiotensin System
11486view11:09, 2 April 2008MarkModified description
11476view15:20, 1 April 2008Thomascosmetic changes
11475view15:16, 1 April 2008Thomaschanged green to darker shade (more easy to read)
11468view12:35, 1 April 2008Thomasfixed anchor links
11459view09:58, 1 April 2008RishiaachaibersingRenin - Angiotensin System
11458view08:35, 1 April 2008MarkRenin - Angiotensin System
11454view07:24, 1 April 2008Mark
11277view14:14, 26 March 2008MarkRenin - Angiotensin System

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC2/3Protein2036 (RGD)
ATF2Protein81647 (Entrez Gene)
AceProtein2493 (RGD)
Ace2Protein728890 (RGD)
Agtr1aProtein2070 (RGD)
Agtr2Protein2072 (RGD)
Angiotensin (1-5)MetaboliteCHEBI:80129 (ChEBI)
Angiotensin (1-7)Metabolite123805 (PubChem-compound)
Angiotensin (1-9)MetaboliteCHEBI:80128 (ChEBI)
Angiotensin 1MetaboliteHMDB0061196 (HMDB)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
Angiotensin IIIMetaboliteHMDB0001036 (HMDB)
Angiotensin IVMetaboliteHMDB0001038 (HMDB)
AngiotensinogenProtein2069 (RGD)
AnpepProtein2991 (RGD)
CA2+MetaboliteHMDB0000464 (HMDB)
CMA1Protein2365 (RGD)
CTSGProtein1307681 (RGD)
CeramideMetaboliteCHEBI:17761 (ChEBI)
Cpa3Protein2390 (RGD)
DAGMetaboliteCHEBI:18035 (ChEBI)
ERK1Protein70500 (RGD)
Elk1Protein1598663 (RGD)
EnpepProtein621228 (RGD)
FAKProtein3443 (RGD)
FosGeneProductENSRNOG00000008015 (Ensembl)
GalfaQ/11ProteinQ9JID2 (Uniprot-TrEMBL)
Grb2Protein81504 (Entrez Gene)
IP3MetaboliteHMDB0001143 (HMDB)
IP3RProteinIPR000493 (InterPro)
IkbkbProtein621375 (RGD)
IkbkgProteinENSRNOG00000060936 (Ensembl)
Itpr1Protein2933 (RGD)
Itpr2Protein69649 (RGD)
Itpr3Protein2934 (RGD)
JNKProteinENSRNOG00000020155 (Ensembl)
Jak2ProteinENSRNOG00000059968 (Ensembl)
LnpepProtein621752 (RGD)
MEKK1Protein620966 (RGD)
MKK4Protein1307040 (RGD)
MKK7Protein1560043 (RGD)
Mapk10Protein3663 (RGD)
Mapk3ProteinENSRNOG00000053583 (Ensembl)
Mapk8Protein621506 (RGD)
Mapk9Protein628847 (RGD)
Mas1Protein3049 (RGD)
MmeProtein3098 (RGD)
NF-KBProtein727889 (RGD)
NOMetaboliteHMDB0003378 (HMDB)
NlnProtein621518 (RGD)
PAK1Protein3250 (RGD)
PAKProtein2.7.11.1 (Enzyme Nomenclature) Cannot find a more specific identifier in this context, see https://en.wikipedia.org/wiki/Serine/threonine-specific_protein_kinase as a start.
PAK2Protein61953 (RGD)
PAK3Protein3251 (RGD)
PAK4Protein1307705 (RGD)
PAK6Protein1306213 (RGD)
PAK7Protein1312009 (RGD)
PI3KProteinENSRNOG00000056371 (Ensembl) Identifier based on similar name for ortholog human gene
PIP2MetaboliteCHEBI:18348 (ChEBI)
PKAProtein3389 (RGD)
PPtaseProtein62018 (RGD)
PYK2Protein628758 (RGD)
Plcb1Protein3344 (RGD)
PpgbProtein1309070 (RGD)
PrkcqProtein620968 (RGD)
PtgIRProtein292661 (Entrez Gene)
ROSMetaboliteCHEBI:26523 (ChEBI)
Rac1Protein619755 (RGD)
Raf1Protein24703 (Entrez Gene)
RasProtein2981 (RGD)
ReninProtein3554 (RGD)
SHCProteinENSRNOG00000020657 (Ensembl) Mapping based on name of ortholog human gene.
SOSProteinIPR023578 (InterPro) Unclear which ortholog is meant, see also: https://en.wikipedia.org/wiki/Son_of_Sevenless
STAT1Protein3771 (RGD)
STAT3Protein3772 (RGD)
TYKProteinENSRNOG00000032948 (Ensembl) Assuming this protein stands for TYK2 (it seems TYK1 is not related to this interaction).
Thop1Protein68330 (RGD)
c-JunProtein2943 (RGD)
cAMPMetaboliteHMDB0000058 (HMDB)
p38Protein3045 (RGD)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP376"
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