RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis (Homo sapiens)

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1Induced upon loss of RIOK1 or RIOK2ChemosensitivityPIK3CAAKT1RIOK2EGFRMTORFOXO3RPL11PTENRIOK1Cell Cycle ArrestApoptosisTP53L11 Ribosomal Stress ResponseReduced upon loss of RIOK1 or RIOK2LegendAKT2AKT3RICTORMLST8MAPKAP1Tumorigenesis


Description

This pathway is based on figure 7 from Read et al. When over-expressed the RIOK1 and RIOK2 proteins signal downstream of Akt to induce tumorigensis. RIOK2 also regulates signaling upstream of AKT through stimulation of the mTORC2 complex (indicated by red interactions). In the absence of RIOK1 and RIOK2 (indicated by blue interactions) the p53-dependent ribosomal stress checkpoint via RPL1 is induced.

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Bibliography

  1. Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, Iwanami A, Yang H, Cavenee WK, Mischel PS, Furnari FB, Thomas JB; ''A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma.''; PLoS Genet, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127936view17:29, 18 January 2024KhanspersOntology Term : 'altered phosphatidylinositol 3-kinase-Akt signaling pathway' added !
127935view17:29, 18 January 2024KhanspersOntology Term : 'glioblastoma' added !
127934view17:25, 18 January 2024Khanspersswapped unconnected pathway nodes for labels
127929view22:11, 17 January 2024Khanspersupdated to Homo sapiens, updated xrefs and description
123360view04:51, 18 July 2022EgonwMade two pathways clickable
108159view10:42, 29 November 2019FehrhartOntology Term : 'cancer' added !
89744view23:50, 29 September 2016KhanspersModified title
89642view23:21, 22 September 2016KhanspersCombined into one diagram
89111view18:41, 22 August 2016AAR&CoDeleted extra comment
89062view06:46, 19 August 2016FehrhartConnected line
88807view22:10, 14 August 2016AAR&CoOntology Term : 'altered stress response pathway' added !
88806view22:09, 14 August 2016AAR&CoOntology Term : 'cancer pathway' added !
88805view22:09, 14 August 2016AAR&CoModified description
88804view22:07, 14 August 2016AAR&CoAdded New Nodes
88803view22:04, 14 August 2016AAR&CoModified description
88799view21:07, 14 August 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductAKT1 (HGNC) AKT Not Specified
AKT2GeneProductAKT2 (HGNC) AKT Not Specified
AKT3GeneProductAKT3 (HGNC) AKT Not Specified
ApoptosisPathwayWP31 (WikiPathways)
Cell Cycle ArrestPathwayWP31 (WikiPathways)
EGFRGeneProductENSG00000146648 (Ensembl)
FOXO3GeneProductFOXO3 (HGNC)
MAPKAP1GeneProductMAPKAP1 (HGNC)
MLST8GeneProductMLST8 (HGNC)
MTORGeneProductMTOR (HGNC)
PIK3CAGeneProductPIK3CA (HGNC)
PTENGeneProductPTEN (HGNC)
RICTORGeneProductRICTOR (HGNC)
RIOK1GeneProductRIOK1 (HGNC)
RIOK2GeneProductRIOK2 (HGNC)
RPL11GeneProductRPL11 (HGNC)
TP53GeneProductTP53 (HGNC)

Annotated Interactions

No annotated interactions

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