Leptin-insulin signaling overlap (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IRSPI3KIRSIRSDNAJAK2PDPK1LEPRPIK3R3AKT1PIK3CGINSRINSDGKZLEPPIP2IRS1PIK3CGIRS2Irs3JAK2PIP3IRS4STAT3JAK2STAT3STAT3SOCS3SOCS2SOCS1Name: Leptin-insulin signaling overlapOrganism: Homo sapiens


Description

Overlap of cellular insulin and leptin signaling. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3935).

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Leptin Insulin Overlap", WP578 revision, with a 95.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:Featured.pngReview changes for Featured
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

  1. Banks AS, Davis SM, Bates SH, Myers MG Jr; ''Activation of downstream signals by the long form of the leptin receptor.''; J Biol Chem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137955
Approved
view20:53, 10 March 2025KhanspersModified description
118425
Featured
view14:24, 27 May 2021Mkutmonremoved unused reference
116797view10:02, 14 May 2021EweitzModified title
107152view14:23, 17 September 2019MaintBotChEBI identifier normalization
106627view20:53, 12 September 2019KhanspersModified description
105633view05:04, 10 August 2019KhanspersModified description
90771view01:19, 14 December 2016KhanspersOntology Term : 'leptin system pathway' added !
90770view01:18, 14 December 2016KhanspersOntology Term : 'insulin signaling pathway' added !
90769view01:18, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
DGKZGeneProductENSG00000149091 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040479
INSGeneProductENSG00000254647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
INSRGeneProductENSG00000171105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1GeneProductENSG00000169047 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
IRS2GeneProductENSG00000185950 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:384783
IRS4GeneProductENSG00000133124 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16370
Irs3GeneProductNo homologues found for original id L:16369
JAK2GeneProductENSG00000096968 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
LEPGeneProductENSG00000174697 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P41160
LEPRGeneProductENSG00000116678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
PDPK1GeneProductENSG00000140992 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PIK3CGGeneProductENSG00000105851 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
SOCS1GeneProductENSG00000185338 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12703
SOCS2GeneProductENSG00000120833 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216233
SOCS3GeneProductENSG00000184557 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12702
STAT3GeneProductENSG00000168610 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3935"
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