TYROBP causal network in microglia (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none GIMAP2TCIRG1DPYDSAMSN1IL13RA1GPX1LGALS9CITGAMBIN2PPP1R18IGSF6PYCARDNCKAP1LSLC1A5FKBP15NPC2CXCL16TYROBPHLXCD4ABCC4SLC7A7RBM47APBB1IPC1QCITGB2ADAP2TMEM106ACAPGSTAT5AELF4RPS6KA1SPP1CREB3L2ZFP36L2RUNX3PLEKNRROSLYL1LOXL3C3NCF2GAPTCD37TGFBR1GAL3ST4CD84ITGAXRNASE6HCLS1IL10RASH2B3CYTL1TNFRSF1BRGS1IL18KCNE3SFT2D2MAFLHFPL2Name: TYROBP causal network in microgliaOrganism: Homo sapiens


Description

The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3945).

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "TYROBP Causal Network", WP3625 revision 85694 with a 96.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access
Homology Converted

Ontology Terms

Bibliography

  1. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V; ''Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.''; Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137098
Approved
view22:51, 27 February 2025KhanspersModified description
135022view12:44, 31 July 2024EweitzRefine node alignment
135021view12:42, 31 July 2024EweitzRefine alignment, standardize node height
135020view12:40, 31 July 2024EweitzEconomize layout
135019view12:31, 31 July 2024EweitzEconomize layout
135018view12:25, 31 July 2024EweitzEconomize layout
135017view12:09, 31 July 2024EweitzIncrease font size
134177view01:06, 16 July 2024EweitzEconomize layout
134176view01:04, 16 July 2024EweitzRefine node padding, alignment
134175view01:02, 16 July 2024EweitzEconomize layout
116679view13:21, 9 May 2021EweitzModified title
116678view12:59, 9 May 2021EweitzModified title
107558view00:00, 20 October 2019AlexanderPicoModified description
105838view23:10, 15 August 2019KhanspersModified description
98920view23:35, 15 October 2018AlexanderPicoModified description
98918view23:25, 15 October 2018AlexanderPicoModified description
90843view19:39, 14 December 2016KhanspersOntology Term : 'microglial cell' added !
90842view19:39, 14 December 2016KhanspersOntology Term : 'innate immune response pathway' added !
90839view19:38, 14 December 2016KhanspersOntology Term : 'Alzheimer disease pathway' added !
90838view19:33, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCC4GeneProductENSG00000125257 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032849
ADAP2GeneProductENSG00000184060 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020709
APBB1IPGeneProductENSG00000077420 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026786
BIN2GeneProductENSG00000110934 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000098112
C1QCGeneProductENSG00000159189 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896
C3GeneProductENSG00000125730 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024164
CAPGGeneProductENSG00000042493 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000056737
CD37GeneProductENSG00000104894 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030798
CD4GeneProductENSG00000010610 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023274
CD84GeneProductENSG00000066294 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038147
CREB3L2GeneProductENSG00000182158 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038648
CXCL16GeneProductENSG00000161921 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018920
CYTL1GeneProductENSG00000170891 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000062329
DPYDGeneProductENSG00000188641 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033308
ELF4GeneProductENSG00000102034 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031103
FKBP15GeneProductENSG00000119321 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000066151
GAL3ST4GeneProductENSG00000197093 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000075593
GAPTGeneProductENSG00000175857 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046006
GIMAP2GeneProductENSG00000106560 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063856
HCLS1GeneProductENSG00000180353 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022831
HLXGeneProductENSG00000136630 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039377
IGSF6GeneProductENSG00000140749 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035004
IL10RAGeneProductENSG00000110324 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032089
IL13RA1GeneProductENSG00000131724 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000017057
IL18GeneProductENSG00000150782 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039217
ITGAMGeneProductENSG00000169896 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786
ITGAXGeneProductENSG00000140678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030789
ITGB2GeneProductENSG00000160255 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290
KCNE3GeneProductENSG00000175538 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035165
LGALS9CGeneProductENSG00000171916 (Ensembl)
LHFPL2GeneProductENSG00000145685 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045312
LOXL3GeneProductENSG00000115318 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000693
LYL1GeneProductENSG00000104903 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034041
MAFGeneProductENSG00000178573 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000055435
NCF2GeneProductENSG00000116701 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480
NCKAP1LGeneProductENSG00000123338 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488
NPC2GeneProductENSG00000119655 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021242
NRROSGeneProductENSG00000174004 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052384
PLEKGeneProductENSG00000115956 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
PPP1R18GeneProductENSG00000146112 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034595
PYCARDGeneProductENSG00000103490 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030793
RBM47GeneProductENSG00000163694 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000070780
RGS1GeneProductENSG00000090104 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026358
RNASE6GeneProductENSG00000169413 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021880
RPS6KA1GeneProductENSG00000117676 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003644
RUNX3GeneProductENSG00000020633 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000070691
SAMSN1GeneProductENSG00000155307 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022876
SFT2D2GeneProductENSG00000213064 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040848
SH2B3GeneProductENSG00000111252 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042594
SLC1A5GeneProductENSG00000105281 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001918
SLC7A7GeneProductENSG00000155465 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000958
SPP1GeneProductENSG00000118785 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029304
STAT5AGeneProductENSG00000126561 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004043
TCIRG1GeneProductENSG00000110719 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001750
TGFBR1GeneProductENSG00000106799 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000007613
TMEM106AGeneProductENSG00000184988 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034947
TNFRSF1BGeneProductENSG00000028137 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028599
TYROBPGeneProductENSG00000011600 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579
ZFP36L2GeneProductENSG00000152518 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045817

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3945"
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