Prader-Willi and Angelman syndrome (Homo sapiens)

From WikiPathways

Jump to: navigation, search
4, 23171561615GABA(A) receptorsubunit rhochr15:22805313unknownfunctionMetaboliteschr15:28390339Gene productFollicle stimulating hormonePathwayHypersensitivebehaviourCleft palateEpilepsyTranscription of INK4/ARF locusMelanocytesRB signallingPWS regionLuteinizing hormoneStem cell differentiationGABA(A) receptorBreakpoint 3telomereAS regionBreakpoint 2centromereBreakpoint 1Non-imprintedidentical with 15q11.2 CNV regionPWRN2EIF4ENUP188GOLGA8SNUP107HTR2CNUP43NUP214TUBGCP6NUP210NUP54TUBGCP5NUP58GOLGA6L2NUP35NUP155TUBGCP2NUP62POM121Gamma-tubulin ring complexNUP205PWRN1SEC13NUP50SEH1LNUP160Signaling pathway in GlioblastomaNUP93AAASPWAR6GLE1DNA repair pathwaysRANBP2NUP85RAE1TPRTUBGCP3NUP133MIR4508NUP37PWRN4NUP42TUBGCP4UBE2NNDC1PWRN3AHCTF1MetaboliteFMR1NUP153NUP88nuclear pore complexNUP98RNF8SLC45A2GABA(A) receptorsubunit deltaHERC2G2/M arrestCCND1LHBMDM4ARFL-dopaquinoneFSHBCCND2Melanin biosynthesisGABA(A) receptor subunit beta-3RB1p16-INK4aCDKN2BCDC6NK3RKISS1P-proteinG1/S progressionCGAApoptosisTyrosinasep53L-tyrosineMDM2CDK4NKB10, 13GABA(A) receptor subunit alpha-5IPWSNORD116@20MAGEL24, 9, 12, 25CYFIP1GABRA5GABRB32, 15Peptide hormone biosynthesisGHRH (1-108)GHRH (32-75)PCSK1TUBGCP5NHLH2Insulin (25-110)20, 22POMC (1-241)Oxytocin-neurophysin 1 (1-125)Ca2+GABRG3Ghrelin (24-51)SNORD115@8NIPA2GNRH1 (24-92)POMC (138-150)NIPA1Spliceosomal A complexATP10ASNORD108mRNA processingMajor splicing pathwayInsulin B chain(25-54)Synthesis, secretion and deacylation of ghrelinInsulin processingSNURFGNRH1 (24-33)SNRPNNDN3, 4, 18UBE3A21BDNF (1-247)MKRN313NPAP1SNORD64SNORD109ASNORD109BNon-imprintedOxytocin (20-28)BDNF (129-247)Ghrelin (1-117)SNURF-SNRPN11Spliceosomal E complexPCSK1Insulin A chain(90-110)Insulin (57-87)CGAE2F1UBE3Ap16-INK4aCDKN2CCCND1CCND2CDK6E2F1OCA215Leptin mediated depolarisation of POMC neurons9, 12Development of hypothalamic anorexigenic circuits253334, 1844, 19Molecular motor kinesinDynein microtubule based molecular motorAxonal transportFormation of centrosomalmicrotubule organising centreMSX1DLX5MAGEL2FEZ2Proteasome degradationpathwayNDNPCM1FEZ1BBS4Neurite/axonal outgrowth2444Neurite outgrowthNGF4FEZ1PRKCZ4BBS4GNRH1888Alternate splicing8, 14Full-length 5HT2C receptorsAdenosine-to-inosineRNA-editing7, 85'-...CGGUAUGUAGCAAUACGUAAUCCUAUUGAGCAUAGCC...-3'SNORD115HTR2C pre-mRNA3'-...GAGUCGCAUUAGGAUAACUCGUACUAA...-5'HTR2C mRNAExon IHTR2CIIIIIIVVaVbVI2mim-stimulation:Gene expression or another process is stimulated by the indicated componentGene or gene productmim-binding: Binding of two indicated componentsmim-conversion: Conversion of one component into another (e.g. prohormone - hormone)mim-catalysation:The indicated component catalyses the reaction that is pointed atmim-inhibition:Gene expression or another process is inhibited by the indicated componentmim-transcription-translation:Stimulation of the indicated component results in transcription/translation of the following productsmim-cleavage:The indicated component or pathway causes the following component or complex to breakBasic arrow:The exact nature of the reaction is unknownAny arrow with dashed line:There might be multiple steps involved between the two indicated components,but the result is as indicated with the arrowmim-gap - dashed line:There is no indication of what process follows the expression of this componentSmall molecule, chemical or metaboliteRefers to an existing pathway that is involvedRNA gene RNAAny arrow coloured grey:The result of the interaction is as indicated with the arrow, but strong evidence for this reaction is lackingGABRR1GABRR2GABRR3GABRG2GABRG1GABRG3GABA(A) receptorsubunit gammaunknownfunction


Description

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are diseases that are both caused by a deletion in the same region of chromosome 15, namely 15q11-q13 (exact position chr15:22805313-28390339 (GRCh37) taken from Kirov et al. 2014 and literature cited there). Due to methylation patterns however, different genes are responsible for the two syndromes. This pathway depicts the currently known downstream molecular interactions of several of the genes involved in PWS and/or AS. For this chromosomal region, also duplications are known.

The colours of the pathway sections correspond to the colours of the genes on top. Dashed lines indicate a gap between a component and the downstream pathway. A rectangle is drawn to improve the clarity of the pathway; darker colours indicate that this particular part is derived from research in other animals than humans.

A detailed description of the pathway has been published by Ehrhart et al.. The published version is WP3998-94544.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N; ''HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.''; Nat Cell Biol, 2010 PubMed Europe PMC Scholia
  2. Homanics GE, DeLorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, Krasowski MD, Rick CE, Korpi ER, Mäkelä R, Brilliant MH, Hagiwara N, Ferguson C, Snyder K, Olsen RW; ''Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  3. Miller NL, Wevrick R, Mellon PL; ''Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development.''; Hum Mol Genet, 2009 PubMed Europe PMC Scholia
  4. Lee S, Walker CL, Karten B, Kuny SL, Tennese AA, O'Neill MA, Wevrick R; ''Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.''; Hum Mol Genet, 2005 PubMed Europe PMC Scholia
  5. Neumann LC, Markaki Y, Mladenov E, Hoffmann D, Buiting K, Horsthemke B; ''The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein.''; Hum Mol Genet, 2012 PubMed Europe PMC Scholia
  6. Chumová J, Trögelová L, Kourová H, Volc J, Sulimenko V, Halada P, Ku�era O, Benada O, Kuchařová A, Klebanovych A, Dráber P, Daniel G, Binarová P; ''γ-Tubulin has a conserved intrinsic property of self-polymerization into double stranded filaments and fibrillar networks.''; Biochim Biophys Acta Mol Cell Res, 2018 PubMed Europe PMC Scholia
  7. Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB; ''Regulation of serotonin-2C receptor G-protein coupling by RNA editing.''; Nature, 1997 PubMed Europe PMC Scholia
  8. Garfield AS, Davies JR, Burke LK, Furby HV, Wilkinson LS, Heisler LK, Isles AR; ''Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2Creceptor mediated appetite.''; Mol Brain, 2016 PubMed Europe PMC Scholia
  9. Colmers WF, Wevrick R; ''Leptin signaling defects in a mouse model of Prader-Willi syndrome: An orphan genetic obesity syndrome no more?''; Rare Dis, 2013 PubMed Europe PMC Scholia
  10. Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA; ''Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.''; Endocrinology, 2011 PubMed Europe PMC Scholia
  11. ''mRNA splicing - major pathway''; Reactome; R-HSA-72163.2, DOI Scholia
  12. Mercer RE, Michaelson SD, Chee MJ, Atallah TA, Wevrick R, Colmers WF; ''Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.''; PLoS Genet, 2013 PubMed Europe PMC Scholia
  13. Abreu AP, Macedo DB, Brito VN, Kaiser UB, Latronico AC; ''A new pathway in the control of the initiation of puberty: the MKRN3 gene.''; J Mol Endocrinol, 2015 PubMed Europe PMC Scholia
  14. Canton H, Emeson RB, Barker EL, Backstrom JR, Lu JT, Chang MS, Sanders-Bush E; ''Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing.''; Mol Pharmacol, 1996 PubMed Europe PMC Scholia
  15. Delahanty RJ, Zhang Y, Bichell TJ, Shen W, Verdier K, Macdonald RL, Xu L, Boyd K, Williams J, Kang JQ; ''Beyond Epilepsy and Autism: Disruption of GABRB3 Causes Ocular Hypopigmentation.''; Cell Rep, 2016 PubMed Europe PMC Scholia
  16. Donnelly MP, Paschou P, Grigorenko E, Gurwitz D, Barta C, Lu RB, Zhukova OV, Kim JJ, Siniscalco M, New M, Li H, Kajuna SL, Manolopoulos VG, Speed WC, Pakstis AJ, Kidd JR, Kidd KK; ''A global view of the OCA2-HERC2 region and pigmentation.''; Hum Genet, 2012 PubMed Europe PMC Scholia
  17. Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL; ''A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
  18. Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K; ''Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.''; J Cell Biol, 1999 PubMed Europe PMC Scholia
  19. ''Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.''; J Cell Biol, 1999
  20. Burnett LC, LeDuc CA, Sulsona CR, Paull D, et al; ''Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi Syndrome''; J Clin Invest, 2017 PubMed Europe PMC Scholia
  21. Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y; ''Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.''; Sci Signal, 2017 PubMed Europe PMC Scholia
  22. Brange J, Langkjoer L; ''Insulin structure and stability.''; Pharm Biotechnol, 1993 PubMed Europe PMC Scholia
  23. Ehrhart F, Janssen KJM, Coort SL, Evelo CT, Curfs LMG2; ''Prader-Willi Syndrome and Angelman Syndrome: Visualisation of the molecular pathways for two chromosomal disorders''; World J Biol Psychiatry, 2018 PubMed Europe PMC Scholia
  24. Lee S, Walker CL, Karten B, Kuny SL, Tennese AA, O'Neill MA, Wevrick R; ''Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth''; Hum Mol Genet, 2005 PubMed Europe PMC Scholia
  25. Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, Bouret SG; ''Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits.''; Hum Mol Genet, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134606view06:26, 23 July 2024EgonwAdded a missing datasource
134605view06:26, 23 July 2024EgonwRemoved template comments
127157view15:16, 7 August 2023Fehrhartlegend correction
127156view15:12, 7 August 2023FehrhartModified description
127155view15:09, 7 August 2023FehrhartModified description
127154view15:07, 7 August 2023Fehrhartupdate
127153view10:31, 7 August 2023Fehrhartupdate
125298view17:32, 31 January 2023LarsgwAdd DOI to reference
123316view12:01, 15 July 2022Fehrhartupdate in progress
123312view10:51, 15 July 2022Fehrhartupdate
123122view18:06, 4 July 2022EgonwMade multiple pathways clickable
119303view13:04, 23 June 2021FinterlyAdded Reactome info to PublicationXref
117171view09:55, 18 May 2021EweitzModified title
113877view16:32, 3 December 2020Fehrhartupdated IPW ID and color (RNA)
106536view00:01, 6 September 2019KhanspersModified description
105788view19:47, 15 August 2019KhanspersModified description
105316view22:47, 29 July 2019AriuttaHGNC -> HGNC Accession number.
101993view19:22, 22 November 2018EgonwRemoved whitespace in PubMed identifiers and duplicate BioPax content.
101842view20:54, 12 November 2018EgonwFixed the upper case of a Uniprot identifier.
101830view09:45, 12 November 2018EgonwReplaced old Uniprot data sources with the new ones.
96172view14:29, 22 February 2018FehrhartAdded reference for pathway publication
96171view13:26, 22 February 2018FehrhartModified description
96170view13:25, 22 February 2018FehrhartModified description
95733view22:42, 18 January 2018AlexanderPicoupdated to TrEMBL
94984view13:49, 23 October 2017DeSlAdded IDs for GABA-receptor units which where missing, added linkout to GABA signalling PW.
94551view16:11, 25 September 2017EgonwReverted to version '14:42, 5 September 2017' by Egonw
94544view14:14, 22 September 2017Fehrhartcorrected some graphical issues
94543view13:09, 22 September 2017SusanQuick edit to datanode annotation or property
94376view14:42, 5 September 2017Fehrhartannotated interactions
94375view12:48, 5 September 2017Fehrhartchange of presentation of protein complex (LH, FSH)
93046view09:05, 27 July 2017FehrhartConnected interaction
92786view10:03, 6 July 2017KJanssenCorrected 1 interaction type
92755view14:21, 3 July 2017KJanssenEdited the legend and some annotations
92753view12:02, 3 July 2017FehrhartGraphical element conversion
92751view07:20, 3 July 2017FehrhartConversion graphical lines in legend
92732view11:48, 1 July 2017KJanssenCorrected a small mistake
92731view11:39, 1 July 2017KJanssenAdded a figure legend
92684view17:46, 28 June 2017MaintBotfixed unconnected
92679view16:23, 28 June 2017KJanssenMade some minor changes to the layout
92649view10:45, 27 June 2017FehrhartOntology Term : 'Angelman syndrome' added !
92648view10:44, 27 June 2017FehrhartModified description
92629view15:43, 22 June 2017KJanssenModified description
92628view15:39, 22 June 2017KJanssenModified description
92627view15:19, 22 June 2017KJanssenModified title
92611view14:15, 20 June 2017KJanssenAdded a part in the GABRB3 section
92610view12:41, 20 June 2017KJanssenFixed references, as this went wrong with the last update
92609view12:33, 20 June 2017KJanssenAdded a section for SNORD115. Also made some minor changes regarding the layout of the pathway.
92567view12:07, 16 June 2017Mkutmonfixed reference
92566view12:00, 16 June 2017KJanssenOntology Term : 'Prader-Willi syndrome' added !
92565view11:59, 16 June 2017KJanssenOntology Term : 'disease pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AAASGeneProductQ9NRG9 (Uniprot-TrEMBL)
AHCTF1GeneProductQ8WYP5 (Uniprot-TrEMBL)
ARFGeneProductQ8N726 (Uniprot-TrEMBL)
ATP10AGeneProductENSG00000206190 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BBS4GeneProductENSG00000140463 (Ensembl)
BDNF (1-247)ProteinP23560 (Uniprot-TrEMBL)
BDNF (129-247)ProteinP23560 (Uniprot-TrEMBL)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CCND2ProteinP30279 (Uniprot-TrEMBL)
CDC6GeneProductQ99741 (Uniprot-TrEMBL)
CDK4ProteinP11802 (Uniprot-TrEMBL)
CDK6ProteinQ00534 (Uniprot-TrEMBL)
CDKN2BProteinP42772 (Uniprot-TrEMBL)
CDKN2CProteinP42773 (Uniprot-TrEMBL)
CGAGeneProductP01215 (Uniprot-TrEMBL)
CYFIP1GeneProductENSG00000273749 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DLX5GeneProductENSG00000105880 (Ensembl)
DNA repair pathwaysPathwayWP4946 (WikiPathways)
E2F1GeneProductENSG00000101412 (Ensembl)
EIF4EGeneProductENSG00000151247 (Ensembl)
Exon IRna
FEZ1GeneProductENSG00000149557 (Ensembl)
FEZ2ProteinENSG00000171055 (Ensembl)
FMR1GeneProductENSG00000102081 (Ensembl)
FSHBGeneProductP01225 (Uniprot-TrEMBL)
G1/S progressionPathwayWP45 (WikiPathways)
G2/M arrestPathway
GABA(A) receptor subunit deltaGeneProductENSG00000187730 (Ensembl)
GABA(A) receptor subunit alpha-5GeneProductP31644 (Uniprot-TrEMBL)
GABA(A) receptor subunit beta-3GeneProductP28472 (Uniprot-TrEMBL)
GABA(A) receptorPathwayWP4159 (WikiPathways)
GABRA5GeneProductENSG00000186297 (Ensembl)
GABRB3GeneProductENSG00000166206 (Ensembl)
GABRG1ProteinENSG00000163285 (Ensembl)
GABRG2ProteinENSG00000113327 (Ensembl)
GABRG3ProteinENSG00000182256 (Ensembl)
GABRR1GeneProduct2569 (Entrez Gene)
GABRR2GeneProduct2570 (Entrez Gene)
GABRR3GeneProduct200959 (Entrez Gene)
GHRH (1-108)ProteinP01286 (Uniprot-TrEMBL)
GHRH (32-75)ProteinP01286 (Uniprot-TrEMBL)
GLE1GeneProductQ53GS7 (Uniprot-TrEMBL)
GNRH1 (24-33)ProteinP01148 (Uniprot-TrEMBL)
GNRH1 (24-92)ProteinP01148 (Uniprot-TrEMBL)
GNRH1ProteinP01148 (Uniprot-TrEMBL)
GOLGA6L2GeneProductENSG00000174450 (Ensembl)
GOLGA8SGeneProductENSG00000261739 (Ensembl)
Gamma-tubulin ring complexComplex
Ghrelin (1-117)ProteinQ9UBU3 (Uniprot-TrEMBL)
Ghrelin (24-51)ProteinQ9UBU3 (Uniprot-TrEMBL)
HERC2GeneProductENSG00000128731 (Ensembl)
HTR2C mRNARnaENSG00000147246 (Ensembl)
HTR2CGeneProductENSG00000147246 (Ensembl)
IIRna
IIIRna
IPWGeneProduct3653 (Entrez Gene)
IVRna
Insulin (25-110)ProteinP01308 (Uniprot-TrEMBL)
Insulin (57-87)ProteinP01308 (Uniprot-TrEMBL)
Insulin A chain

(90-110)

ProteinP01308 (Uniprot-TrEMBL)
Insulin B chain

(25-54)

ProteinP01308 (Uniprot-TrEMBL)
Insulin processingPathwayWP2736 (WikiPathways)
KISS1ProteinQ15726 (Uniprot-TrEMBL)
L-dopaquinoneMetaboliteCHEBI:16852 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
LHBGeneProductP01229 (Uniprot-TrEMBL)
MAGEL2GeneProductENSG00000254585 (Ensembl)
MDM2GeneProductQ00987 (Uniprot-TrEMBL)
MDM4GeneProductO15151 (Uniprot-TrEMBL)
MIR4508RnaENSG00000265673 (Ensembl)
MKRN3GeneProductENSG00000179455 (Ensembl)
MSX1GeneProductENSG00000163132 (Ensembl)
Melanin biosynthesisPathwayWP3377 (WikiPathways)
MetaboliteMetabolite
NDC1GeneProductQ9BTX1 (Uniprot-TrEMBL)
NDNGeneProductENSG00000182636 (Ensembl)
NGFGeneProductENSG00000134259 (Ensembl)
NHLH2GeneProductENSG00000177551 (Ensembl)
NIPA1GeneProductENSG00000170113 (Ensembl)
NIPA2GeneProductENSG00000140157 (Ensembl)
NK3RProteinP29371 (Uniprot-TrEMBL)
NKBProteinQ2UVB8 (Uniprot-TrEMBL)
NPAP1GeneProductENSG00000185823 (Ensembl)
NUP107GeneProductP57740 (Uniprot-TrEMBL)
NUP133GeneProductQ8WUM0 (Uniprot-TrEMBL)
NUP153GeneProductP49790 (Uniprot-TrEMBL)
NUP155GeneProductO75694 (Uniprot-TrEMBL)
NUP160GeneProductQ12769 (Uniprot-TrEMBL)
NUP188GeneProductQ5SRE5 (Uniprot-TrEMBL)
NUP205GeneProductQ92621 (Uniprot-TrEMBL)
NUP210GeneProductQ8TEM1 (Uniprot-TrEMBL)
NUP214GeneProductP35658 (Uniprot-TrEMBL)
NUP35GeneProductQ8NFH5 (Uniprot-TrEMBL)
NUP37GeneProductQ8NFH4 (Uniprot-TrEMBL)
NUP42GeneProductO15504 (Uniprot-TrEMBL)
NUP43GeneProductQ8NFH3 (Uniprot-TrEMBL)
NUP50GeneProductQ9UKX7 (Uniprot-TrEMBL)
NUP54GeneProductQ7Z3B4 (Uniprot-TrEMBL)
NUP58GeneProductQ9BVL2 (Uniprot-TrEMBL)
NUP62GeneProductP37198 (Uniprot-TrEMBL)
NUP85GeneProductQ9BW27 (Uniprot-TrEMBL)
NUP88GeneProductQ99567 (Uniprot-TrEMBL)
NUP93GeneProductQ8N1F7 (Uniprot-TrEMBL)
NUP98GeneProductP52948 (Uniprot-TrEMBL)
OCA2GeneProductENSG00000104044 (Ensembl)
Oxytocin (20-28)ProteinP01178 (Uniprot-TrEMBL)
Oxytocin-neurophysin 1 (1-125)ProteinP01178 (Uniprot-TrEMBL)
P-proteinProteinQ04671 (Uniprot-TrEMBL)
PCM1GeneProductENSG00000078674 (Ensembl)
PCSK1GeneProductENSG00000175426 (Ensembl)
POM121GeneProductQ96HA1 (Uniprot-TrEMBL)
POMC (1-241)ProteinP01189 (Uniprot-TrEMBL)
POMC (138-150) ProteinP01189 (Uniprot-TrEMBL)
PRKCZGeneProductENSG00000067606 (Ensembl)
PWAR6RnaENSG00000257151 (Ensembl)
PWRN1GeneProductENSG00000259905 (Ensembl)
PWRN2GeneProductENSG00000260551 (Ensembl)
PWRN3GeneProductENSG00000260760 (Ensembl)
PWRN4GeneProductENSG00000260232 (Ensembl)
Peptide hormone biosynthesisPathwayWP2691 (WikiPathways)
Proteasome

degradation

pathway		PathwayWP183 (WikiPathways)
RAE1GeneProductP78406 (Uniprot-TrEMBL)
RANBP2GeneProductP49792 (Uniprot-TrEMBL)
RB1ProteinP06400 (Uniprot-TrEMBL)
RNF8GeneProductENSG00000112130 (Ensembl)
SEC13GeneProductP55735 (Uniprot-TrEMBL)
SEH1LGeneProductQ96EE3 (Uniprot-TrEMBL)
SLC45A2GeneProductENSG00000164175 (Ensembl)
SNORD108GeneProductENSG00000239014 (Ensembl)
SNORD109AGeneProductENSG00000274640 (Ensembl)
SNORD109BGeneProductENSG00000239169 (Ensembl)
SNORD115@GeneProduct692218 (Entrez Gene)
SNORD116@GeneProduct692236 (Entrez Gene)
SNORD64GeneProductENSG00000276610 (Ensembl)
SNRPNGeneProductENSG00000128739 (Ensembl)
SNURF-SNRPNGeneProductENSG00000128739 (Ensembl)
SNURFGeneProductENSG00000273173 (Ensembl)
Signaling pathway in GlioblastomaPathwayWP2261 (WikiPathways)
Spliceosomal A complexComplexR-HSA-72068.3 (Reactome)
Spliceosomal E complexComplexR-HSA-72057.3 (Reactome)
Synthesis, secretion

and deacylation of

ghrelin		PathwayWP3436 (WikiPathways)
TPRGeneProductP12270 (Uniprot-TrEMBL)
TUBGCP2GeneProductENSG00000130640 (Ensembl)
TUBGCP3GeneProductENSG00000126216 (Ensembl)
TUBGCP4GeneProductENSG00000137822 (Ensembl)
TUBGCP5GeneProductENSG00000153575 (Ensembl)
TUBGCP5GeneProductENSG00000275835 (Ensembl)
TUBGCP6GeneProductENSG00000128159 (Ensembl)
TyrosinaseProteinP14679 (Uniprot-TrEMBL)
UBE2NGeneProductENSG00000177889 (Ensembl)
UBE3AGeneProductENSG00000114062 (Ensembl)
VIRna
VaRna
VbRna
mRNA processing Major splicing pathwayPathwayWP411 (WikiPathways)
nuclear pore complexComplexCPX-873 (Complex Portal)
p16-INK4aProteinP42771 (Uniprot-TrEMBL)
p53ProteinP04637 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3998"
Personal tools