Distal convoluted tubule 1 (DCT1) cell (Mus musculus)

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2ACTIVEPhosphorylatedProteinHigh PotassiumPro-UrineActiveComplexApical Membranekir5.1Na+Cl-kir4.1KS-WNK1K+Cl-Low PotassiumWNK4PKinaseScaffoldCab39TerminalKinaseSPAKPWNK1PKS-WNK1Cab39SPAKWNK1WNK4Cl-InactiveComplexKinaseScaffoldTerminalKinasekir5.1CLC-K2kir4.1K+Na+Cl-Apical MembranePCLC-K2Cl-K+Na+Cl-NCCPINACTIVENa+Cl-NCCK+Cl-Cl-


The major function of the distal convoluted tubule 1 cell (DCT1 cell) in the kidney is to maintain proper iron, solute and water homeostasis. The cells are polarized and located in the nephron duct where they have unique transport functions which are maintained by specialized K(+), Na(+), and Cl(-) channels in the proximal or distal part of the cell.

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Ontology Terms



  1. Hamilton KL, Devor DC; ''Basolateral membrane K+ channels in renal epithelial cells.''; Am J Physiol Renal Physiol, 2012 PubMed Europe PMC Scholia
  2. Welling PA; ''Roles and Regulation of Renal K Channels.''; Annu Rev Physiol, 2016 PubMed Europe PMC Scholia


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118998view09:31, 8 June 2021FinterlyRemoved empty Comment
117871view10:18, 23 May 2021EweitzModified title
106890view13:36, 17 September 2019MaintBotHMDB identifier normalization
104964view13:25, 27 June 2019Fehrhartadded ion fluxes according to Welling et al.
104963view13:18, 27 June 2019FehrhartModified description
104962view13:14, 27 June 2019Fehrhartconnected line
101911view17:09, 16 November 2018EgonwUsed the supported Uniprot-TrEMBL data source name.
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95348view13:23, 6 December 2017AgustinGVOntology Term : 'kidney distal convoluted tubule epithelial cell' added !
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External references


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NameTypeDatabase referenceComment
CLC-K2ProteinQ9WUB6 (Uniprot-TrEMBL)
Cab39ProteinQ06138 (Uniprot-TrEMBL)
Cl-MetaboliteHMDB0000492 (HMDB)
K+MetaboliteHMDB0000586 (HMDB)
KS-WNK1ProteinP83741-7 (Uniprot-TrEMBL)
NCCProteinP59158 (Uniprot-TrEMBL)
Na+MetaboliteHMDB0000588 (HMDB)
SPAKProteinQ9Z1W9 (Uniprot-TrEMBL)
WNK1ProteinP83741 (Uniprot-TrEMBL)
WNK4ProteinQ80UE6 (Uniprot-TrEMBL)
kir4.1ProteinQ9jm63 (Uniprot-TrEMBL)
kir5.1ProteinQ9Z307 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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