Mevalonate arm of cholesterol biosynthesis pathway with inhibitors (Homo sapiens)

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326-fluoromevalonate 5-diphosphateFDFT1HMGCRCinnamic acidFDPS2-fluoromevalonate 5-diphosphateMVKHMGCS1dimethylallyl-PPfarnesyl thiodiphosphaterosuvastatinzoledronic acidIDI1BPH-628cholesterol synthesis(+)-Zaragozic acidAcetyl-CoAacetoacetyl-CoAL-6596993-hydroxy-3-methylglutaryl-CoAmevaldyl-CoAmevalonate4mevalonate-Pmevalonate-PPisopenthyl-PPPMVKMVDgeranyl-PPfamesyl-PPgeranylgeranyl-PPpresqualene-PPsqualeneprotein prenylationGGPS1IDI2GGPS1cerivastatinatorvastatinlovastatinsimvastatinCHEMBL39312CHEMBL39102Fluvastatin3-hydroxy-3-methyl-6-phosphohexanoic acidisoferulic acidp-coumaric aciddiphosphoglycolyl prolineCHEMBL1160330CHEMBL1160328P'-geranyl 2-fluoromevalonate 5-diphosphateP'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphateNE97220RisedronateNE58062NE58018BPH-608BPH-675BPH-629BPH-676BPH-628BPH-608BPH-675BPH-629BPH-676BPH-830CHEMBL24362sq-109CHEMBL1208103[1-(Hydroxycarbamoyl)-4-(3-phenoxyphenyl)butyl]phosphonateCHEMBL1207858Compound 13 (1-Methyl-1-{[3-(3-phenoxyphenyl)propyl]carbamoyl}ethyl)phosphonate1


Description

An analysis of the mevalonate branch of the cholesterol biosynthesis pathway, and a set of inhibitors directed against targets in this pathway. Inhibitors which have been found for Homo Sapiens are coloured red, those found for Rattus norvegicus orange. View more details on where these reactions in the cell take place at [1]. View the broader scope of cholesterol metabolism at [2].

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Quality Tags

Ontology Terms

 

Bibliography

  1. Halaris AE, Belendiuk KT, Freedman DX; ''Antidepressant drugs affect dopamine uptake.''; Biochem Pharmacol, 1975 PubMed Europe PMC Scholia
  2. Greenspan MD, Yudkovitz JB, Lo CY, Chen JS, Alberts AW, Hunt VM, Chang MN, Yang SS, Thompson KL, Chiang YC; ''Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.''; Proc Natl Acad Sci U S A, 1987 PubMed Europe PMC Scholia
  3. Benson HE, Watterson S, Sharman JL, Mpamhanga CP, Parton A, Southan C, Harmar AJ, Ghazal P; ''Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.''; Br J Pharmacol, 2017 PubMed Europe PMC Scholia
  4. Haines BE, Wiest O, Stauffacher CV; ''The increasingly complex mechanism of HMG-CoA reductase.''; Acc Chem Res, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124610view19:48, 15 November 2022EgonwReplaced an old Wikidata identifier
124607view19:36, 15 November 2022EgonwReplaced an old Wikidata identifier
123456view05:06, 28 July 2022EgonwMade a pathway clickable
120000view08:05, 9 October 2021EgonwNot a conversion
110281view07:52, 2 May 2020EgonwReplaced three InChIKeys with PubChem-compound identifiers.
110261view15:30, 30 April 2020EgonwReplaced an InChIKey with a PubChem CID.
110009view18:19, 12 April 2020EgonwFixed the PubMed identifier. It's freaking 19!!!!
108848view14:27, 3 February 2020DeSlAdded lit. ref for mevaldyl-CoA structure drawing.
108847view14:20, 3 February 2020DeSlAdded inchiKeys for previsouly missing inhibitor nodes.
108846view14:14, 3 February 2020DeSlUpdated layout.
106783view13:26, 17 September 2019MaintBotHMDB identifier normalization
101731view12:37, 2 November 2018DeSlModified description
101728view12:35, 2 November 2018DeSlModified description
98185view14:59, 2 August 2018DeSlAdded chembl compound prefix for IDs.
97916view16:46, 23 June 2018EgonwFixed a data source.
97507view13:37, 24 May 2018Jessev1993Changed annotation from enzyme nomenclature to Uniprot annotion
96454view11:41, 15 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
95821view13:41, 22 January 2018DeSlConnected unconnected line
95415view12:20, 14 December 2017DeSlchanged misspelled node.
95414view12:18, 14 December 2017DeSlOntology Term : 'cholesterol biosynthetic pathway' added !
95413view12:18, 14 December 2017DeSlOntology Term : 'altered cholesterol biosynthetic pathway' added !
95412view12:13, 14 December 2017DeSlAdded wikidata as database source where applicable
95411view12:09, 14 December 2017DeSlModified description
95410view12:07, 14 December 2017DeSlAdded ID for cholestreol pathway
95409view11:49, 14 December 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(+)-Zaragozic acidMetaboliteCHEBI:83934 (ChEBI)
(1-Methyl-1-{[3-(3-phenoxyphenyl)propyl] carbamoyl}ethyl)phosphonateMetabolite44185378 (PubChem-compound)
2-fluoromevalonate 5-diphosphateMetaboliteQ27071897 (Wikidata) Only found for Rattus norvegicus.
3-hydroxy-3-methyl-6-phosphohexanoic acidMetaboliteQ27073729 (Wikidata) Only found for Rattus norvegicus.
3-hydroxy-3-methylglutaryl-CoAMetaboliteQ27108899 (Wikidata)
6-fluoromevalonate 5-diphosphateMetaboliteQ27074009 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
BPH-608MetaboliteQ27075443 (Wikidata)
BPH-628MetaboliteQ27075447 (Wikidata)
BPH-629MetaboliteQ27075449 (Wikidata)
BPH-675MetaboliteQ27075451 (Wikidata)
BPH-676MetaboliteQ27075453 (Wikidata)
BPH-830MetaboliteQ27075459 (Wikidata)
CHEMBL1160328MetaboliteCHEMBL1160328 (ChEMBL compound)
CHEMBL1160330MetaboliteCHEMBL1160330 (ChEMBL compound)
CHEMBL1207858MetaboliteCHEMBL1207858 (ChEMBL compound)
CHEMBL1208103MetaboliteCHEMBL1208103 (ChEMBL compound)
CHEMBL24362MetaboliteCHEMBL24362 (ChEMBL compound)
CHEMBL39102MetaboliteCHEMBL39102 (ChEMBL compound)
CHEMBL39312MetaboliteCHEMBL39312 (ChEMBL compound)
Cinnamic acidMetaboliteHMDB0000567 (HMDB) Only found for Rattus norvegicus.
Compound 13 Metabolite44185378 (PubChem-compound) PMID: 19456099
FDFT1ProteinQ21108578 (Wikidata)
FDPSProteinQ21107439 (Wikidata)
FluvastatinMetaboliteQ417942 (Wikidata)
GGPS1ProteinQ21106540 (Wikidata)
HMGCRProteinP04035 (Uniprot-TrEMBL)
HMGCS1ProteinQ21118293 (Wikidata)
IDI1ProteinQ21151146 (Wikidata)
IDI2ProteinQ21132842 (Wikidata)
L-659699Metabolite6440895 (PubChem-compound) Only found for Rattus norvegicus. L-659699 is a.k.a. (E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid
MVDProteinP53602 (Uniprot-TrEMBL)
MVKProteinQ424031 (Wikidata)
NE58018Metabolite405372 (PubChem-compound)
NE58062MetaboliteQ27087889 (Wikidata)
NE97220MetaboliteQ27087890 (Wikidata)
P'-geranyl 2-fluoromevalonate 5-diphosphateMetaboliteQ27088347 (Wikidata)
P'-geranyl 3,5,9-trihydroxy-3- methylnonanate 9-diphosphateMetabolite11650985 (PubChem-compound) Only found for Rattus norvegicus.
PMVKProteinQ22676988 (Wikidata)
RisedronateMetaboliteHMDB0015022 (HMDB)
[1-(Hydroxycarbamoyl)-4- (3-phenoxyphenyl)butyl]phosphonateMetabolite44185382 (PubChem-compound)
acetoacetyl-CoAMetaboliteQ2639429 (Wikidata)
atorvastatinMetaboliteQ668093 (Wikidata)
cerivastatinMetaboliteQ423439 (Wikidata)
cholesterol synthesisPathwayWP197 (WikiPathways)
dimethylallyl-PPMetaboliteQ417398 (Wikidata)
diphosphoglycolyl prolineMetaboliteQ27077077 (Wikidata)
famesyl-PPMetaboliteQ2699676 (Wikidata)
farnesyl thiodiphosphateMetaboliteQ27077283 (Wikidata)
geranyl-PPMetaboliteQ418125 (Wikidata)
geranylgeranyl-PPMetaboliteQ774795 (Wikidata)
isoferulic acidMetaboliteQ27096447 (Wikidata) Only found for Rattus norvegicus.
isopenthyl-PPMetaboliteQ417403 (Wikidata)
lovastatinMetaboliteQ417740 (Wikidata)
mevaldyl-CoAMetabolite
mevalonate-PPMetaboliteQ45415198 (Wikidata)
mevalonate-PMetaboliteQ27464491 (Wikidata)
mevalonateMetaboliteQ27109878 (Wikidata)
p-coumaric acidMetaboliteQ99374 (Wikidata) Only found for Rattus norvegicus.
presqualene-PPMetaboliteQ27088444 (Wikidata)
protein prenylationPathway
rosuvastatinMetaboliteQ415159 (Wikidata)
simvastatinMetaboliteQ670131 (Wikidata)
sq-109MetaboliteQ7392720 (Wikidata)
squaleneMetaboliteQ407560 (Wikidata)
zoledronic acidMetaboliteQ28852343 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4189"
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