Non-genomic actions of 1,25-dihydroxyvitamin D3 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none StressTLR2/4/8ligandsTranscription of:?Plasma membraneCell deathTranscription of anti-viral genesTLR2TLR8IKK2MED1PLA2CYP27B1SP3PMAVSECD40LGDAG25DAAETS1TLR4PRKCEPRKCHPRKCQPRKCGPRKCBPRKCAPRKCDJAK1IFNR alphaTYK2CaMK2ACaMK2BCaMK2GCaMK2DSTAT1STAT2IFNR gamma 1IFNR gamma 2Caveolin-1VDRm/nIFI44LISG15OAS1OAS2OAS3RSAD2IFI27LRXRBRXRGRXRA1,25DVDRPLCB1PLCB2PLCB3PLCB4PLCG1PLCD1PLCD3PLCD4PLCE1PLCG2PIK3CAPIK3CBPIK3CGPIK3CDPIK3R1PIK3R3PIK3R4PIK3R5PIK3C2APIK3C2BPIK3C2GAKT1AKT2AKT3PIK3R2PIK3C325DVDRnCD40IFN gammaIFN alphaCYP27B1VDRSTAT2STAT1AA1,25DVDRVDRnSP1VDRcJUNVDR transcriptionKRASHRASNRASMAPK3MAPK1MAPK7MAPK8MAPK9PKC zetaVDRnNFKB1RELBNFKB2NFKB1RELBNFKB2MAPK8MAPK9TNFR1TNFMAPK11MAPK14MAPK13MAPK12MAPK11MAPK14MAPK13MAPK12Gene transcriptionCYP24A1CAMPDEFB4ANOD2VDRCCL2CXCL8IL-6Gene transcriptionNucleusIon channelsName: Non-genomic actions of 1,25-dihydroxyvitamin D3Organism: Homo sapiens


Description

The pathway summarizes non-genomic actions of the hormonally active form of vitamin D: 1,25-dihydroxyvitamin D3. It is based the pathway figure published by Hii and Ferrante (Nutrients, 2016).

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

  1. Hii CS, Ferrante A; ''The Non-Genomic Actions of Vitamin D.''; Nutrients, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134957
Approved
view09:37, 30 July 2024EgonwRemoved an identifier without datasource
134806view03:04, 27 July 2024EweitzFix colliding graphics for nucleus and cell membranes
134804view03:02, 27 July 2024EweitzModified title
134803view03:02, 27 July 2024EweitzModified description
122900view11:55, 31 May 2022DeSlOntology Term : 'signaling pathway' added !
122899view11:51, 31 May 2022DeSlAdded missing IDs for IFNR alpha and gamma
122898view11:41, 31 May 2022DeSlConverted metabolite DataNodes to blue blocks, annotated DAG.
107169view14:25, 17 September 2019MaintBotChEBI identifier normalization
98497view08:39, 13 September 2018SusanModified description
98496view08:26, 13 September 2018SusanModified description
98495view08:23, 13 September 2018SusanOntology Term : 'vitamin D signaling pathway' added !
98494view08:20, 13 September 2018SusanNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
1,25DMetaboliteHMDB0001903 (HMDB)
25DMetaboliteHMDB0003550 (HMDB)
AAMetaboliteHMDB0001043 (HMDB)
AKT1GeneProductENSG00000142208 (GenBank)
AKT2GeneProductENSG00000105221 (GenBank)
AKT3GeneProductENSG00000117020 (GenBank)
CAMPGeneProductENSG00000164047 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CD40GeneProductENSG00000101017 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CYP24A1GeneProductENSG00000019186 (Ensembl)
CYP27B1GeneProductENSG00000111012 (Ensembl)
CaMK2AGeneProductENSG00000070808 (Ensembl)
CaMK2BGeneProductENSG00000058404 (Ensembl)
CaMK2DGeneProductENSG00000145349 (Ensembl)
CaMK2GGeneProductENSG00000148660 (Ensembl)
Caveolin-1ProteinQ03135 (Uniprot-TrEMBL)
DAGMetaboliteLMGL0201 (LIPID MAPS)
DEFB4AGeneProductENSG00000171711 (Ensembl)
ETS1GeneProductENSG00000134954 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IFI27LGeneProductENSG00000119632 (Ensembl)
IFI44LGeneProductENSG00000137959 (Ensembl)
IFN alphaProteinP01563 (Uniprot-TrEMBL)
IFN gammaProteinP01579 (Uniprot-TrEMBL)
IFNR alphaProteinP48551 (Uniprot-TrEMBL) AKA interferon-α/β receptor (IFNAR)
IFNR gamma 1ProteinP15260 (Uniprot-TrEMBL) The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains
IFNR gamma 2ProteinP38484 (Uniprot-TrEMBL) The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains
IKK2GeneProductENSG00000104365 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK7GeneProductENSG00000166484 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NOD2GeneProductENSG00000167207 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
OAS1GeneProductENSG00000089127  (Ensembl)
OAS2GeneProductENSG00000111335 (Ensembl)
OAS3GeneProductENSG00000111331  (Ensembl)
PIK3C2AGeneProductENSG00000011405 (GenBank)
PIK3C2BGeneProductENSG00000133056 (GenBank)
PIK3C2GGeneProductENSG00000139144  (GenBank)
PIK3C3GeneProductENSG00000078142  (GenBank)
PIK3CAGeneProductENSG00000121879 (GenBank)
PIK3CBGeneProductENSG00000051382 (GenBank)
PIK3CDGeneProductENSG00000171608 (GenBank)
PIK3CGGeneProductENSG00000105851 (GenBank)
PIK3R1GeneProductENSG00000145675 (GenBank)
PIK3R2GeneProductENSG00000105647 (GenBank)
PIK3R3GeneProductENSG00000117461 (GenBank)
PIK3R4GeneProductENSG00000196455 (GenBank)
PIK3R5GeneProductENSG00000141506 (GenBank)
PKC zetaGeneProductENSG00000067606 (Ensembl)
PLA2GeneProductIPR001211 (InterPro) Enzyme family, EC 3.1.1.4 [https://en.wikipedia.org/wiki/Phospholipase_A2]
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PLCD1GeneProductENSG00000187091 (Ensembl)
PLCD3GeneProductENSG00000187091 (Ensembl)
PLCD4GeneProductENSG00000187091 (Ensembl)
PLCE1GeneProductENSG00000138193 (Ensembl)
PLCG1GeneProductENSG00000187091 (Ensembl)
PLCG2GeneProductENSG00000197943 (Ensembl)
PMAMetaboliteCHEBI:37537 (ChEBI)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCDGeneProductENSG00000163932 (Ensembl)
PRKCEGeneProductENSG00000171132 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PRKCHGeneProductENSG00000027075 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RELBGeneProductENSG00000104856 (Ensembl)
RSAD2GeneProductENSG00000134321 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SP3GeneProductENSG00000172845 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFR1GeneProductENSG00000067182 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
VDRGeneProductENSG00000111424 (Ensembl)
VDRm/nGeneProductENSG00000111424 (Ensembl)
VDRnGeneProductENSG00000111424 (Ensembl)
VSEGeneProduct
cJUNGeneProductENSG00000177606 (Ensembl)

Annotated Interactions

No annotated interactions

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