Omega-9 fatty acid synthesis (Mus musculus)

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1Acsl1FasnFads1CoA(20:0)Lauric acidMyristic acidCoA(16:0)CoA(16:1(9Z))CoA(18:1(9Z))CoA(18:2(6Z,9Z))CoA(20:1(11Z))CoA(20:2(8Z,11Z))18:2(6Z,9Z)Stearic acid16:1(9Z)CoA(18:0)Palmitic acidAcsl3Acsl4Elovl2Elovl5Elovl6Elovl3CoA(22:0)CoA(24:0)Elovl1CoA(26:0)Arachidic acidBehenic acidLignoceric acidCerotic acidCoA(22:1(13Z))CoA(24:1(15Z))Scd220:2(8Z,11Z)CoA(20:3(5Z,8Z,11Z))20:3(5Z,8Z,11Z)Fads2Oleic acidAcot1Acot2Acot124:1(15Z))cis-erucic acidAcot2


Description

This pathway is inspired by the Lipidmaps>Omega-9 and other fatty acids [1].

Omega-9 FAs (Fatty acids) are fats which can be obtained from diet, but also produced endogenously. These lipids are monounsaturated (indicating one double bonds in the lipid tail).The position of the double bond is counted from the tail end of the lipid chain.

This pathway also indicated saturated fats (without a double bond), such as stearic acid, arachidic acid etc.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126146view12:57, 11 April 2023Ash iyerupdated node
126145view12:56, 11 April 2023Ash iyerProtein complexes data node added
126107view12:08, 6 April 2023Conroy lipidsfix wrong identifiers, add some EC
124740view08:47, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
124342view16:07, 17 October 2022Conroy lipidsadd more rheas
124337view13:46, 17 October 2022Conroy lipidsStart to change arrows to mim-conversion, add Rhea annotation
120255view11:18, 21 November 2021Egonwreverted. correction: proper conversion, but wrong ID.
120254view11:16, 21 November 2021EgonwInteraction is a mim-translocation
117934view10:42, 23 May 2021EweitzModified title
106337view08:57, 21 August 2019DeSlAdded general LipidMaps publication.
106290view15:21, 19 August 2019DeSlOntology Term : 'fatty acid elongation pathway' added !
106287view15:20, 19 August 2019DeSlOntology Term : 'fatty acid metabolic pathway' added !
106286view15:20, 19 August 2019DeSlOntology Term : 'PW:0000002' removed !
106285view15:20, 19 August 2019DeSlOntology Term : 'unsaturated fatty acid biosynthetic pathway' added !
106284view15:19, 19 August 2019DeSlUpdated layout, connect catalysis MIM to group iso individual enzymes, added missing metabolite.
106281view14:49, 19 August 2019DeSlModified description
98614view12:57, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98581view15:56, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
16:1(9Z)MetaboliteLMFA01030056 (LIPID MAPS)
18:2(6Z,9Z)MetaboliteLMFA01030332 (LIPID MAPS)
20:2(8Z,11Z)MetaboliteLMFA01030377 (LIPID MAPS)
20:3(5Z,8Z,11Z)MetaboliteLMFA01030381 (LIPID MAPS)
24:1(15Z))MetaboliteLMFA01030377 (LIPID MAPS) AKA cis-selacholeic acid
Acot1GeneProduct26897 (Entrez Gene)
Acot2GeneProduct171210 (Entrez Gene)
Acsl1GeneProduct14081 (Entrez Gene)
Acsl3GeneProduct74205 (Entrez Gene)
Acsl4GeneProduct50790 (Entrez Gene)
Arachidic acidMetaboliteLMFA01010020 (LIPID MAPS)
Behenic acidMetaboliteLMFA01010022 (LIPID MAPS)
Cerotic acidMetaboliteLMFA01010026 (LIPID MAPS)
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(16:1(9Z))MetaboliteLMFA07050359 (LIPID MAPS)
CoA(18:0)MetaboliteLMFA07050369 (LIPID MAPS)
CoA(18:1(9Z))MetaboliteLMFA07050356 (LIPID MAPS)
CoA(18:2(6Z,9Z))MetaboliteLMFA07050060 (LIPID MAPS)
CoA(20:0)MetaboliteLMFA07050329 (LIPID MAPS)
CoA(20:1(11Z))MetaboliteLMFA07050093 (LIPID MAPS)
CoA(20:2(8Z,11Z))MetaboliteLMFA07050061 (LIPID MAPS)
CoA(20:3(5Z,8Z,11Z))MetaboliteLMFA07050062 (LIPID MAPS)
CoA(22:0)MetaboliteLMFA07050289 (LIPID MAPS)
CoA(22:1(13Z))MetaboliteLMFA07050318 (LIPID MAPS)
CoA(24:0)MetaboliteLMFA07050372 (LIPID MAPS)
CoA(24:1(15Z))MetaboliteLMFA07050098 (LIPID MAPS)
CoA(26:0)MetaboliteLMFA07050327 (LIPID MAPS)
Elovl1GeneProduct54325 (Entrez Gene)
Elovl2GeneProduct54326 (Entrez Gene)
Elovl3GeneProduct12686 (Entrez Gene)
Elovl5GeneProduct68801 (Entrez Gene)
Elovl6GeneProduct170439 (Entrez Gene)
Fads1GeneProduct76267 (Entrez Gene)
Fads2GeneProduct56473 (Entrez Gene)
FasnGeneProduct14104 (Entrez Gene)
Lauric acidMetaboliteLMFA01010012 (LIPID MAPS)
Lignoceric acidMetaboliteLMFA01010024 (LIPID MAPS)
Myristic acidMetaboliteLMFA01010014 (LIPID MAPS)
Oleic acidMetaboliteLMFA01030002 (LIPID MAPS)
Palmitic acidMetaboliteLMFA01010001 (LIPID MAPS)
Scd2GeneProduct20250 (Entrez Gene)
Stearic acidMetaboliteLMFA01010018 (LIPID MAPS)
cis-erucic acidMetabolite112-86-7 (CAS) AKA cis-selacholeic acid

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
Behenic acidmim-conversion40784 (Rhea)
CoA(16:0)CoA(16:1(9Z))mim-conversion36932 (Rhea)
CoA(16:1(9Z))16:1(9Z)mim-conversion40132 (Rhea) EC:3.1.2.2
CoA(18:0)Stearic acidmim-conversion30140 (Rhea)
CoA(18:1(9Z))CoA(18:2(6Z,9Z))mim-conversion25857 (Rhea)
CoA(18:1(9Z))Oleic acidmim-conversion40140 (Rhea)
CoA(18:2(6Z,9Z))18:2(6Z,9Z)mim-conversion40144 (Rhea) EC:3.1.2.2
CoA(20:0)Arachidic acidmim-conversion40148 (Rhea)
CoA(24:0)Lignoceric acidmim-conversion40788 (Rhea)
CoA(26:0)Cerotic acidmim-conversion40792 (Rhea)
Palmitic acidCoA(16:0)mim-conversion30752 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4351"
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