DNA replication (Danio rerio)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cdc6Orc3Mcm2Ubiquitinated Cdc6Mcm4DNA polymerase alpha: primase: origin complexUbiquitinated Orc1ADPRNA primer-DNA primerCdt1Degraded by proteasome in cytosolATPPre-replicative complexDegraded by proteasome in cytosolwith the replication forkOrc3Orc complexMcm10dUTPPhosphorylation of Mcm 2-7 complexOrc complexATPOrc4Orc complexCTPUbiquitinOrc2ADPMcm64. Switching of origins to post-replicative stateMcm61. Assembly of the pre-replicative complexOrc5DNA polymerase alpha: primase: origin complexMcm3UbiquitindATPOrc4aMcm5Cdc6Mcm 4,6,7 trimer forms and associates2. Activation of the pre-replicative complexOrc complexCdc6Mcm3Mcm5RNA primer-DNA primerPhosphorylated Orc1Orc3ATPRFC140Orc2Mcm7p70RFC36Orc2Orc5Cdt1RFC Heteropentamer:RNA primer-DNA primerCdt1RNA primer-DNA primer:origin duplex:PCNARNA Primer5. Leading/lagging strand synthesisCdt1Mcm2Cdt1PCNA homotrimerMcm4PrimaseOriginCdc6RFC38ATPPhosphorylated Cdc6GTPRFC Heteropentamer:RNA primer-DNA primer:DNA PolymeraseOrc5GemininOrc Complexp49dCTPRFC40p58Processive complexOrc3Mcm7RFC37Pre-replicative complexdGTPp1803. DNA replication initiationOrc1Orc2UTPzgc:110727CDC6POLE2zgc:77841rfc4rfc5rpa2UBCPOLEPOLD1mcm2pcnarfc3mcm5zgc:77827zgc:85772pold2rpa1UBA52MCM10POLA1ASKzgc:101602prim1POLD3gmnnORC2RFC1orc3lMCM6mcm3CDT1zgc:56598zgc:56310orc6mcm4MCM7POLD4RPA4zgc:56264zgc:110810orc1POLA2Name: DNA replicationLast Modified: 10/17/2013Organism: Danio rerio


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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View approved pathways at the new wikipathways.org.

Quality Tags

Image:Unconnected.pngFix interactions
Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : DNA replication pathway
 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116856
Approved
view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ASKGeneProduct
CDC6GeneProductENSDARG00000009942 (Ensembl)
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2GeneProductENSDARG00000101465 (Ensembl)
POLA1GeneProductENSDARG00000045308 (Ensembl)
POLA2GeneProductENSDARG00000015070 (Ensembl)
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProductENSDARG00000076169 (Ensembl)
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProductENSDARG00000054799 (Ensembl)
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProductENSDARG00000102632 (Ensembl)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1GeneProductENSDARG00000039217 (Ensembl)
orc3lGeneProduct334315 (Entrez Gene)
orc6GeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProductENSDARG00000095046 (Ensembl)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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