TNF-alpha NF-kB signaling pathway (Rattus norvegicus)

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ECDeubiquitinationDesumoylationAutophosphorylationLigandReceptorCY ->NUCY ->NUCytoplasmExtracellularPMEndosomeENProteins in a complex interactionPlasma membraneGolgi apparatusProteolytic cleavageRecruitmentMolecular associationUbiquitinationMolecule in the pathwayEnzyme complexCYEndoplasmic reticulumCY ->NUNUControlActivationDMethylationDemethylationPhosphorylationSumoylationERPalmitoylationCY ->NUInhibitionAccession Number: NetPath 9; cellmap:9MitochondrionDeacetylation(Protein-protein interaction)GODephosphorylationCY ->NUAcetylationMTGlycosylationTranslocationReaction through unknown mechanisms/moleculesNucleusPolr1cTraf2TRAF5TraddRipk1Map2k5PrkacaTAB3YWHAQNfkb1GeneChukRipk1Traf2UBCH5CFaddRelaTnfTbk1NfkbibGeneLrpprcCsnk2a1Psmd13RGD1561988TnfYwhaeNr2c2RelFblCasp2Cul1TraipCyldMap3k7ip2Fbxw11RELBTbk1Akt1Tnfrsf1aRelaPsmd6Ube2iHsp90ab1DapTraf3POLR1DHspb1Psmd1TnfCasp8Tnfrsf8SKP1ATraf6Cops3Nkiras1Traf4Rps6ka5Rps6kb1CflarTnfCasp8ap2Ptpn11Hdac1Birc3Kpna2Cav1GeneGsk3bNfkbiaPsmc3Gtf2iRelaCapn3CASP10Ripk3ChukTnip1IkbkgRGD1561333Usp2Polr1aNsmafTnfHIST3H3AlplNfkb2CrebbpKTN1RelGeneNfkbizIkbkeBtrcPrkczPmlKpna6Bcl3Psmd12Wdr68Mcm5Tnfrsf1aIQGAP2Map3k1Hdac6TankTnfrsf1aFlnaDpf2Psmc2Psmb5Birc2RELBAkap8Polr1bPEG3Ripk2Map3k14IkbkbPolr1eMap3k3POLRY2HUnc5clTnip2LOC685179Pdcd2PPP1R13LGnb2l1Gab1Trpc4apNr2c2Casp7TBKBP1Map3k3Bag4Birc3Mtif2TXLNARnf25NfkbieGene SymbolUsp11Ddx3xNkiras2Rpl4COMMD1SUMO1Zfand5Psmd3TRAF1IkbkgSrcNfkbiaAzi2Cd3eapTraf2RPS13BCL7ARPL6YwhabActl6aTRAF1Fkbp5Nfkb1Smarcb1Ube2d2Tnfrsf1bPkn1Pfdn2Stat1Csnk2a2NALP4YwhagKpna3TifaGlg1Psmc1Smarcc1Casp3Rps11Smarca4CraddPtk2Rnf216Fancd2Psmd7TraddMAP3K7IP1Kcnq1Hdac2Map3k8CDC34Faf1TnfAkt2Pebp1LOC681193Rpl30RelaTNFAIP3Traf4RGD1309922Pias3Cdc37PapolaTnfrsf1bMcm7YwhahG3bp2Smarce1Rasal2Tnfrsf11aNfkb1NfkbiaIkbkapTnfrsf1bPpp2caHsp90aa1YwhazMark2Birc2Csnk2bMap3k2


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 85% conversion rate.

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History

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CompareRevisionActionTimeUserComment
117025view11:52, 16 May 2021EweitzModified title
69441view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67702view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41766view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34134view19:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32438view17:16, 15 August 2009MaintBotFixed text labels
32108view13:47, 14 August 2009MaintBotFixed group labels
31458view21:14, 13 August 2009MaintBotFixed text labels
30990view00:56, 30 July 2009MaintBotConverted from Homo sapiens
21642view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP457]]: Moved to stable identifier
8450view13:46, 7 January 2008MaintBot[[Pathway:Rat:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7841view16:22, 18 December 2007MaintBotfixed category names
7309view12:42, 4 November 2007MaintBotAdded categories to GPML
6603view22:20, 22 May 2007A.Pandeygpml file for [[Rat:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
Actl6aGeneProduct361925 (Entrez Gene)
Akap8GeneProduct116633 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
Akt2GeneProduct25233 (Entrez Gene)
AlplGeneProduct25586 (Entrez Gene)
Azi2GeneProduct316051 (Entrez Gene)
BCL7AGeneProduct360809 (Entrez Gene)
Bag4GeneProduct361167 (Entrez Gene)
Bcl3GeneProduct680611 (Entrez Gene)
Birc2GeneProduct60371 (Entrez Gene)
Birc3GeneProduct78971 (Entrez Gene)
BtrcGeneProduct361765 (Entrez Gene)
CASP10GeneProduct
CDC34GeneProduct299602 (Entrez Gene)
COMMD1GeneProduct289831 (Entrez Gene)
Capn3GeneProduct29155 (Entrez Gene)
Casp2GeneProduct64314 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp7GeneProduct64026 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Casp8ap2GeneProduct313128 (Entrez Gene)
Cav1GeneProduct25404 (Entrez Gene)
Cd3eapGeneProduct680493 (Entrez Gene)
Cdc37GeneProduct114562 (Entrez Gene)
CflarGeneProduct117279 (Entrez Gene)
ChukGeneProduct309361 (Entrez Gene)
Cops3GeneProduct287367 (Entrez Gene)
CraddGeneProduct314756 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Csnk2a1GeneProduct116549 (Entrez Gene)
Csnk2a2GeneProduct307641 (Entrez Gene)
Csnk2bGeneProduct81650 (Entrez Gene)