Blood clotting and drug effects (Homo sapiens)

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1PathwayStimulates platelet aggregationCauses vasodilationCross-linked fibrinLegendInhibitionCauses vasoconstrictionCatalysisMetabolic conversionInhibits platelet aggregationVitamin KThrombinThromboxane A2CoumadinFibrinogenProthrombinProstaglandin H2Thromboxane A2Arachidonic acidCOXVitamin K pathwayFibrinProstacyclinNSAIDsEicosanoidsynthesisMetaboliteProtein


Formation of a blood clot by arachidonic acid. This pathway also shows various stimulants/inhibitors that have an effect on the pathway, while also showing the two compounds which respectively cause vasoconstriction/vasodilation and inhibit/stimulate platelet aggregation.

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Ontology Terms



  1. Glen D. Lawrence; ''The Fats of Life: Essential Fatty Acids in Health and Disease''; 978-0-8135-4677-3, 2010


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123582view12:39, 4 August 2022DeSlAdded 3 PW nodes, updated legend
123319view07:48, 16 July 2022EgonwTyped a datanode
119307view13:10, 23 June 2021FinterlyAdded ISBN for book citation
105276view21:38, 25 July 2019KhanspersModified title
105273view21:25, 25 July 2019Khanspersconverted interactions in legend to graphical lines
105234view13:36, 23 July 2019EgonwFibrinogen is a protein complex.
105094view19:02, 5 July 2019AlexanderPicoModified title
104812view10:40, 19 June 2019ChrisAdded legend
104497view10:47, 29 May 2019Chris-Improved visuals of the pathway

- Added annotations

- Fixed text labels
104447view13:19, 27 May 2019ChrisModified title
104446view12:57, 27 May 2019ChrisModified description
104240view21:31, 10 May 2019KhanspersModified description
104059view07:03, 30 April 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
104056view13:21, 29 April 2019DeSlOntology Term : 'coagulation cascade pathway' added !
104055view13:15, 29 April 2019ChrisNew pathway

External references


View all...
NameTypeDatabase referenceComment
Arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
COXProteinIPR038147 (InterPro)
CoumadinMetaboliteCHEBI:10034 (ChEBI)
Cross-linked fibrinPathwayWP4927 (WikiPathways)
Eicosanoid synthesisPathwayWP167 (WikiPathways)
FibrinMetaboliteCHEBI:5054 (ChEBI)
FibrinogenProteinQ381899 (Wikidata)
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
ProstacyclinMetaboliteCHEBI:15552 (ChEBI)
Prostaglandin H2MetaboliteCHEBI:15554 (ChEBI)
ProthrombinMetaboliteCHEBI:8583 (ChEBI)
ThrombinMetaboliteCHEBI:9574 (ChEBI)
Thromboxane A2MetaboliteCHEBI:15627 (ChEBI)
Vitamin K pathwayPathwayWP5186 (WikiPathways)
Vitamin KMetaboliteCHEBI:28384 (ChEBI)

Annotated Interactions

No annotated interactions

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