Monoterpene biosynthesis pathway in mint (Vitis vinifera)

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2(-)-Limonene(-)-trans-CarveolISPIMNR 1PR(+)-Menthofuran(+)-Neoisomenthol(-)-Menthol(+)-Isomenthone(+)-NeomentholL3H(+)-IsomentholMFS(+)-cis-IsopulegoneMMR 1ISPDISPRCDH(-)-Menthone(+)-Pulegone(-)-Carvone(-)-trans-IsopiperitenolLSGeranyl diphosphateL6H1111MMR 2111111111MNR 21


Description

Monoterpenes (C10) are the major group of compounds within the essential oils of the mint (Lamiaceae) family. Peppermint (Mentha × piperita)is considered a model system for the study of monoterpene metabolism, which main steps are depicted in this pathway.


This pathway is annotated well enough for data analysis, however please do not add the "Approved Version" tag yet, since this allocates the PW to the incorrect species (grape vs mint). The WikiPathways team is working on a solution.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Croteau RB, Davis EM, Ringer KL, Wildung MR; ''(-)-Menthol biosynthesis and molecular genetics.''; Naturwissenschaften, 2005 PubMed Europe PMC Scholia
  2. McConkey ME, Gershenzon J, Croteau RB; ''Developmental regulation of monoterpene biosynthesis in the glandular trichomes of peppermint.''; Plant Physiol, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117377view10:26, 21 May 2021EweitzModified title
108774view08:31, 29 January 2020DeSlModified description
108773view08:31, 29 January 2020DeSlModified description
107973view13:35, 18 November 2019Fehrhartconnected unconnected line
107751view16:42, 31 October 2019DeSlModified description
107750view16:39, 31 October 2019DeSlAdded general lit. ref for PW.
107749view16:38, 31 October 2019DeSlConnected all unconnected lines (added anchors to the conversion arrows).
106609view12:24, 11 September 2019Marvin M2Ontology Term : 'monoterpene biosynthetic pathway' added !
106605view20:34, 10 September 2019VAishwaryaModified title
106604view20:34, 10 September 2019VAishwaryaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(+)-IsomentholMetabolite
(+)-IsomenthoneMetaboliteC11952 (KEGG Compound)
(+)-MenthofuranMetaboliteC18025 (KEGG Compound)
(+)-NeoisomentholMetabolite
(+)-NeomentholMetaboliteC00553 (KEGG Compound)
(+)-PulegoneMetaboliteC09893 (KEGG Compound)
(+)-cis-IsopulegoneMetaboliteC11951 (KEGG Compound)
(-)-CarvoneMetaboliteC01767 (KEGG Compound)
(-)-LimoneneMetaboliteC00521 (KEGG Compound)
(-)-MentholMetaboliteC00400 (KEGG Compound)
(-)-MenthoneMetaboliteC00843 (KEGG Compound)
(-)-trans-CarveolMetaboliteC00964 (KEGG Compound)
(-)-trans-IsopiperitenolMetaboliteC01123 (KEGG Compound)
CDHProteinABR15424.1 (NCBI Protein) (-)-trans-carveol dehydrogenase https://www.ncbi.nlm.nih.gov/protein/148887811
Geranyl diphosphateMetaboliteC00341 (KEGG Compound)
ISPDProtein(-)-Isopiperitenol / (-)-carveol dehydrogenase

---------ISPD-1------------ M. longifolia Chromosome: 2 Location Identifier: Mlong585_04858 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: 137 Homology to Canonical Genes: 98 %identity to Q5C9I9 ---------ISPD-2------------ M. longifolia Chromosome: 2 Location Identifier: Mlong585_04874 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: 137 Homology to Canonical Genes: 98 %identity to Q5C9I9 ---------ISPD-L1------------ M. longifolia Chromosome: 2 Location Identifier: Mlong585_04859 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: 127 Homology to Canonical Genes: 72 % identity to Q5C9I9 ---------ISPD-L2------------ M. longifolia Chromosome: 2 Location Identifier: Mlong585_04873 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: 127

Homology to Canonical Genes: 72 % identity to Q5C9I9
ISPIProtein(+)-cis-isopulegone isomerase
ISPRProteinAAQ75422.1 (NCBI Protein) (-)-trans-isopipertenone reductase

(-)-Isopiperitenone reductase https://www.ncbi.nlm.nih.gov/protein/34559416 ---------ISPR-1------------ M. longifolia Chromosome: 11 Location Identifier: Mlong585_36604 Number of Introns: 4 Expression Level in Glandular Trichomes[TPM]: 20 Homology to Canonical Genes: 94 % identity to Q6WAU1 ---------ISPR-2------------ M. longifolia Chromosome: 11 Location Identifier: Mlong585_36605 Number of Introns: 4 Expression Level in Glandular Trichomes[TPM]: 20

Homology to Canonical Genes: 99 % identity to Q6WAU1
L3HProteinAIS36971.1 (NCBI Protein) (-)-Limonene 3-hydroxylase

https://www.ncbi.nlm.nih.gov/protein/693445895 ---------L3H-1------------ M. longifolia Chromosome: 5 Location Identifier: Mlong585_17637 Number of Introns: 1 Expression Level in Glandular Trichomes[TPM]: 2281 Homology to Canonical Genes: 99 % identity to Q9XHE7 ---------L3H-2------------ M. longifolia Chromosome: 5 Location Identifier: Mlong585_17629 Number of Introns: 1 Expression Level in Glandular Trichomes[TPM]: 2281 Homology to Canonical Genes: 99 % identity to Q9XHE7 ---------L3H-3------------ M. longifolia Chromosome: 9 Location Identifier: Mlong585_30867 Number of Introns: 1 Expression Level in Glandular Trichomes[TPM]: 2475 Homology to Canonical Genes: 97 % identity to Q9XHE7 ---------L3H-4------------ M. longifolia Chromosome: 9 Location Identifier: Mlong585_30867 Number of Introns: 1 Expression Level in Glandular Trichomes[TPM]: 2475

Homology to Canonical Genes: 97 % identity to Q9XHE7
L6HProteinAAT39473.1 (NCBI Protein) (-)-limonene 6-hydroxylase https://www.ncbi.nlm.nih.gov/protein/47933782
LSProteinAGN90912.1 (NCBI Protein) (-)-Limonene Synthase

https://www.ncbi.nlm.nih.gov/protein/511636128 ---------LS-1------------ M. longifolia Chromosome: 5 Location Identifier: Mlong585_17628 Number of Introns: 6 Expression Level in Glandular Trichomes[TPM]: 5246 Homology to Canonical Genes: 98% identity to Q40322 ---------LS-2------------ M. longifolia Chromosome: 5 Location Identifier: Mlong585_17636 Number of Introns: 6 Expression Level in Glandular Trichomes[TPM]: 5246

Homology to Canonical Genes: 98% identity to Q40322
MFSProteinABW86890.1 (NCBI Protein) (+)-menthofuran synthase

https://www.ncbi.nlm.nih.gov/protein/158979036 ---------MFS-L1------------ M. longifolia Chromosome: 2 Location Identifier: Mlong585_05231 Number of Introns: 2 Expression Level in Glandular Trichomes[TPM]: 1180

Homology to Canonical Genes: 90 % identity to Q947B7
MMR 1ProteinANA95861.1 (NCBI Protein) (-)-methone:(-)-menthol reductase

https://www.ncbi.nlm.nih.gov/protein/1023043139 ---------MMR-L1------------ M. longifolia Chromosome: 11 Location Identifier: Mlong585_36607 Number of Introns: 6 Expression Level in Glandular Trichomes[TPM]: 107 Homology to Canonical Genes: 87 %identity to Q9XHE7

MMR 2ProteinANA95861.1 (NCBI Protein) (-)-methone:(-)-menthol reductase

https://www.ncbi.nlm.nih.gov/protein/1023043139 ---------MMR-L1------------ M. longifolia Chromosome: 11 Location Identifier: Mlong585_36607 Number of Introns: 6 Expression Level in Glandular Trichomes[TPM]: 107

Homology to Canonical Genes: 87 %identity to Q9XHE7
MNR 1ProteinAAQ55959.1 (NCBI Protein) (-)-Menthone:(+)-isomenthol reductase-like

https://www.ncbi.nlm.nih.gov/protein/33950276 ---------MNR-L1------------ M. longifolia Chromosome: 11 Location Identifier: Mlong585_36608 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: n/a

Homology to Canonical Genes: pseudogene (premature stop codon)
MNR 2ProteinAAQ55959.1 (NCBI Protein) (-)-Menthone:(+)-isomenthol reductase-like

https://www.ncbi.nlm.nih.gov/protein/33950276 ---------MNR-L1------------ M. longifolia Chromosome: 11 Location Identifier: Mlong585_36608 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: n/a

Homology to Canonical Genes: pseudogene (premature stop codon
PRProteinAAQ75423.1 (NCBI Protein) (+)-pulegone reductase

https://www.ncbi.nlm.nih.gov/protein/34559418 ---------PulR-1------------ M. longifolia Chromosome: 3 Location Identifier: Mlong585_09229 Number of Introns: 4 Expression Level in Glandular Trichomes[TPM]: 3116 Homology to Canonical Genes: 95 % identity to Q6WAU0 ---------PulR-2------------ M. longifolia Chromosome: 3 Location Identifier: Mlong585_09276 Number of Introns: 4 Expression Level in Glandular Trichomes[TPM]: 3116 Homology to Canonical Genes: 95 % identity to Q6WAU0 Mlong585_09276 ---------PulR-3------------ M. longifolia Chromosome: 3 Location Identifier: Mlong585_09230 Number of Introns: 0 Expression Level in Glandular Trichomes[TPM]: n/a Homology to Canonical Genes: pseudogene (premature stop codon) ---------PulR-L1------------ M. longifolia Chromosome: 2 Location Identifier: Mlong585_06346 Number of Introns: 4 Expression Level in Glandular Trichomes[TPM]: 153 Homology to Canonical Genes: 92 % identity to Q6WAU0

Annotated Interactions

No annotated interactions

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