Eicosanoid metabolism via lipooxygenases (LOX) (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 5,12 DiHETELTA4H12(R)-HpETE5-HEDHLTA4MBDALOX15BArachidonic acidGGTALOX5LTB4RLTB4R2PPARALXA415-epi-LXA415-epi-LXB4LXB4CYP4A11CYP4A22CYP4A22CYP4F12CYP4F215-HpETE15-HETE8-HpETE8-HETE15-oxoETEALOX15LXA4HPGD12-HpETE12-HETE12-oxoETEALOX12HXB3HXA3TXA3TXB3HXEH12-HEDHLXB4LTB412-epi-LTB46-trans-12-epi-delta-LTB46-trans-delta-LTB4LTC4LTD4LTE4EXC4EXD4EXE420-hydroxy-LTB420-carboxy-LTB418-carboxy-dinor-LTB411-trans-LTC411-trans-LTD411-trans-LTE45-HpETE5-HETE5-oxoETE15-oxo-LXA413,14-dihydro-15-oxo-LXA412-oxo-LTB4LTC4SACOX1ACOX2ACOX3EHHADHACAA1Ggt1GGT5DPEP1Dpep2PTGR1PTGR2ALOX12ALOX5PTGR1PTGR2HPGDALOX5LTA4HLTC4SCYSLTR1CYSLTR2FPR2ALOX15BALOX15ALOX15ALOX12ALOX12PPARAPPARDTRPA1TRPV1ALOX5ALOX515-HETEALOX15ALOX125,12-diHETEALOX15ALOX15BALOX15ALOX12ALOX12Name: Eicosanoid metabolism via lipooxygenases (LOX)Organism: Homo sapiens


Description

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [[1](https://lipidmaps.org/pathway/pathways_maps)].

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) [[2](https://www.wikipathways.org/index.php/Pathway:WP4347)], lipooxygenases (LOX)[[3](https://www.wikipathways.org/index.php/Pathway:WP4348)], or cytochrome P450 monooxygenases (CYP) [[4](https://www.wikipathways.org/index.php/Pathway:WP4349)]. This pathway visualises the second route, via LOX.

Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4348_106329.gpml] with a 88.0% conversion rate.

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Quality Tags

Image:Wplogo_31.pngCommunity: Lipids and LIPID MAPS
Image:Curated.pngApproved version
Image:Featured.pngFeatured version
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Pathway Ontology : drug pathway
Disease : glioblastoma
Cell Type : glial cell
 

Bibliography

  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
  2. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  3. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137444
Approved
Featured
view12:45, 2 March 2025EgonwFixed the BIoPax
137443view12:42, 2 March 2025EgonwModified description
137440view12:39, 2 March 2025EgonwModified description
137439view12:39, 2 March 2025EgonwModified description
124745
Lipids
view08:50, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
124603view19:23, 15 November 2022EgonwReplaced an old LIPID MAPS identifier
116526view11:45, 7 May 2021EweitzModified title
116525view11:20, 7 May 2021EweitzModified description
107598view15:15, 23 October 2019DeSlNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
11-trans-LTC4MetaboliteLMFA03020020 (LIPID MAPS)
11-trans-LTD4MetaboliteLMFA03020021 (LIPID MAPS)
11-trans-LTE4MetaboliteLMFA03020022 (LIPID MAPS)
12(R)-HpETE MetaboliteLMFA03060070 (LIPID MAPS)
12-HEDHGeneProduct
12-HETEMetaboliteLMFA03060088 (LIPID MAPS)
12-HpETEMetaboliteLMFA03060013 (LIPID MAPS) AKA 12S-HpETE
12-epi-LTB4MetaboliteLMFA03020015 (LIPID MAPS)
12-oxo-LTB4MetaboliteLMFA03020024 (LIPID MAPS)
12-oxoETEMetaboliteLMFA03060019 (LIPID MAPS)
13,14-dihydro- 15-oxo-LXA4MetaboliteLMFA03040008 (LIPID MAPS)
15-HETEMetaboliteLMFA03060087 (LIPID MAPS) "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
15-HpETEMetaboliteLMFA03060014 (LIPID MAPS) "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
15-epi-LXA4Metabolite
15-epi-LXB4Metabolite
15-oxo-LXA4MetaboliteLMFA03040009 (LIPID MAPS)
15-oxoETEMetaboliteLMFA03060051 (LIPID MAPS)
18-carboxy- dinor-LTB4MetaboliteLMFA03020056 (LIPID MAPS)
20-carboxy-LTB4MetaboliteLMFA03020016 (LIPID MAPS)
20-hydroxy-LTB4MetaboliteLMFA03020018 (LIPID MAPS)
5,12 DiHETEMetabolite
5,12-diHETEMetaboliteLMFA03060052 (LIPID MAPS)
5-HEDHGeneProduct
5-HETEMetaboliteLMFA03060084 (LIPID MAPS)
5-HpETEMetaboliteLMFA03060108 (LIPID MAPS)
5-oxoETEMetaboliteLMFA03060011 (LIPID MAPS)
6-trans-12-epi-delta-LTB4MetaboliteLMFA03020014 (LIPID MAPS)
6-trans-delta-LTB4MetaboliteLMFA03020013 (LIPID MAPS)
8-HETEMetaboliteLMFA03060086 (LIPID MAPS)
8-HpETEMetaboliteLMFA03060073 (LIPID MAPS)
ACAA1GeneProductENSG00000060971 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
ACOX1GeneProductENSG00000161533 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX2GeneProductENSG00000168306 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
ACOX3GeneProductENSG00000087008 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
ALOX12ProteinENSG00000108839 (Ensembl)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
ALOX15BProteinENSG00000179593 (Ensembl)
  • Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936
ALOX15ProteinENSG00000161905 (Ensembl)
  • Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
ALOX5ProteinENSG00000012779 (Ensembl)
  • AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P48999
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
CYP4A11GeneProductENSG00000187048 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
CYP4A22GeneProductENSG00000162365 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12GeneProductENSG00000186204 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2GeneProductENSG00000186115 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
CYSLTR1ProteinENSG00000173198 (Ensembl)
  • AKA Cysteinyl leukotriene receptor 1, also termed CYSLTR1 [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q99JA4
CYSLTR2ProteinENSG00000152207 (Ensembl)
  • AKA Cysteinyl leukotriene receptor 2, also termed CYSLTR [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q920A1
DPEP1GeneProductENSG00000015413 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13479
Dpep2GeneProductNo homologues found for original id L:319446
EHHADHGeneProductENSG00000113790 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
EXC4MetaboliteLMFA03020031 (LIPID MAPS)
EXD4MetaboliteLMFA03020032 (LIPID MAPS)
EXE4MetaboliteLMFA03020033 (LIPID MAPS)
FPR2ProteinENSG00000171049 (Ensembl)
  • AKA N-formyl peptide receptor 2 (FPR2), because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. [https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88536
GGTProtein
GGT5GeneProductENSG00000099998 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23887
Ggt1GeneProductNo homologues found for original id L:14598
HPGDGeneProductENSG00000164120 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
HXA3MetaboliteLMFA03090005 (LIPID MAPS)
HXB3MetaboliteLMFA03090003 (LIPID MAPS)
HXEHGeneProduct
LTA4HGeneProductENSG00000111144 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16993
LTA4MetaboliteLMFA03020023 (LIPID MAPS)
LTB4MetaboliteLMFA03020001 (LIPID MAPS)
LTB4R2ProteinENSG00000213906 (Ensembl)
  • AKA Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2 [https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JJL9
LTB4RProteinENSG00000213903 (Ensembl)
  • AKA Leukotriene B4 receptor 1[https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_1]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88855
LTC4MetaboliteLMFA03020003 (LIPID MAPS)
LTC4SGeneProductENSG00000213316 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17001
LTD4MetaboliteLMFA03020006 (LIPID MAPS)
LTE4MetaboliteLMFA03020002 (LIPID MAPS)
LXA4Metabolite
LXA4MetaboliteLMFA03040001 (LIPID MAPS)
LXB4MetaboliteLMFA03040002 (LIPID MAPS)
MBDProtein
PPARAProteinENSG00000186951 (Ensembl)
  • AKA Peroxisome proliferator-activated receptor alpha
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204
PPARDProteinENSG00000112033 (Ensembl)
  • AKA Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ) [https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396
PTGR1GeneProductENSG00000106853 (Ensembl)
  • AKA Ltb4dh
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
PTGR2GeneProductENSG00000140043 (Ensembl)
  • AKA Zadh1
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
TRPA1ProteinENSG00000104321 (Ensembl)
  • AKA Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1 or TRPA1 [https://en.wikipedia.org/wiki/TRPA1]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8BLA8
TRPV1ProteinENSG00000196689 (Ensembl)
  • AKA The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1 [https://en.wikipedia.org/wiki/TRPV1]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q704Y3
TXA3MetaboliteLMFA03030005 (LIPID MAPS)
TXB3MetaboliteLMFA03030006 (LIPID MAPS)

Annotated Interactions

No annotated interactions
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