Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ActivationNeutrophil activationChemotaxisMHC class II moleculesImmunoglobulin subunitsT cell receptor(TCR) subunitsTCR signaling kinasesLegendT cell surface moleculesSARS-CoV-2 ORFsNKRFPRG3CRPMMP25LBPNLRP1HLA-DRAHLA-DRB1HLA-DRB4HLA-DRB5nsp9nsp10IGLC2IGHEIGLL1IGHG4IGHG2IGHG1IL8IL6CD4CD8BCD8ACD2CD247CD3GCD3ETRBC1TRACLCKZAP70FYNNegative regulation of gene expressionPositive regulation of gene expressionName: Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complexOrganism: Homo sapiens


Description

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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Quality Tags

Image:Curated.pngApproved version
Image:Featured.pngFeatured version
Image:Featured.pngCurrent Highlight
Image:Wplogo_31.pngCommunity: COVID-19

Ontology Terms

Bibliography

  1. Qiming Liang, Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, View ORCID ProfileYafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu; ''Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis''; https://doi.org/10.1101/2020.03.31.019216, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135048
Approved
Featured
view10:55, 2 August 2024EweitzRefine legend
135047view10:52, 2 August 2024EweitzEconomize layout
135045view21:28, 1 August 2024EweitzUse gene symbols
124646
COVID
view13:05, 18 November 2022IsabelWassinkChanged viral protein shape to rounded rectangles
120646view15:34, 22 December 2021EweitzTighten graphics, fix labels
119112view13:26, 17 June 2021Finterlyadded PMID
118879view12:06, 3 June 2021EweitzOntology Term : 'COVID-19' added !
116727view10:25, 11 May 2021EweitzModified title
111618view20:42, 29 August 2020EgonwModified title
111113view09:20, 13 July 2020EgonwMade the include pathway clickable
110229view14:23, 27 April 2020EgonwAdded the NCBI gene identifier for LBP
110023view19:22, 12 April 2020AlexanderPicoOntology Term : 'regulatory pathway' added !
110022view19:21, 12 April 2020AlexanderPicoOntology Term : 'inflammatory response pathway' added !
110021view19:21, 12 April 2020AlexanderPicoOntology Term : 'disease pathway' added !
110020view19:20, 12 April 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
110019view19:20, 12 April 2020AlexanderPicoModified title
110017view19:18, 12 April 2020AlexanderPicoUpdated representation of ORFs and interactions per standards
109953view18:43, 7 April 2020EgonwAdded two identifiers.
109923view17:40, 6 April 2020Khanspersfixed unconnected
109916view16:58, 6 April 2020KhanspersOntology Term : 'viral infectious disease' added !
109904view19:59, 5 April 2020Rex D A BInteractions
109895view18:25, 4 April 2020Rex D A BNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8BGeneProduct926 (Entrez Gene)
CRPGeneProduct1401 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
LBPGeneProduct3929 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MMP25 GeneProduct64386 (Entrez Gene)
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct5725029 (Entrez Gene)
PRG3GeneProduct10394 (Entrez Gene)
SARS-CoV-2 ORFsPathwayWP4846 (WikiPathways)
TRACGeneProduct28755 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)
nsp10ProteinQ87917572 (Wikidata)
nsp9ProteinQ89686805 (Wikidata)

Annotated Interactions

No annotated interactions

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