COVID-19 adverse outcome pathway (Homo sapiens)
From WikiPathways
Description
Experimental pathway to investigate overlap of Covid-19 downstream effects and adverse outcome pathways related to lung injury.
Quality Tags
Ontology Terms
Pathway Ontology : nicotinamide adenine dinucleotide biosynthetic pathway nicotinamide adenine dinucleotide metabolic pathway kynurenine metabolic pathway de novo nicotinamide adenine dinucleotide biosynthetic pathway nicotinamide adenine nucleotide utilization pathway nicotinamide adenine dinucleotide biosynthesis, the salvage pathway tryptophan degradation pathway
Bibliography
- Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S; ''A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.''; Circ Res, 2000 PubMed Europe PMC Scholia
- Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, Halappanavar S; ''Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes.''; Part Fibre Toxicol, 2016 PubMed Europe PMC Scholia
- Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, Evelo CT, Hongisto V, Kohonen P, Willighagen E, Grafström RC; ''A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.''; Toxicol Sci, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
ACE2 | GeneProduct | 59272 (Entrez Gene) ![]() | |
AGT | GeneProduct | 183 (Entrez Gene) ![]() | |
CCL2 | GeneProduct | 6347 (Entrez Gene) ![]() | |
CCL3 | GeneProduct | 6348 (Entrez Gene) ![]() | |
CSF3 | GeneProduct | 1440 (Entrez Gene) ![]() | |
CXCL10 | GeneProduct | 3627 (Entrez Gene) ![]() | |
Cytokines and
inflammatory response | Pathway | WP530 (WikiPathways) ![]() | |
IL10 | GeneProduct | 3586 (Entrez Gene) ![]() | |
IL1B | GeneProduct | 3553 (Entrez Gene) ![]() | |
IL2 | GeneProduct | 3558 (Entrez Gene) ![]() | |
IL2RA | GeneProduct | 3559 (Entrez Gene) ![]() | |
IL6 | GeneProduct | 3569 (Entrez Gene) ![]() | |
IL7 | GeneProduct | 3574 (Entrez Gene) ![]() | |
IL8 | GeneProduct | 3576 (Entrez Gene) ![]() | |
LTF danger signal response pathway | Pathway | WP4478 (WikiPathways) ![]() | |
Lung fibrosis | Pathway | WP3624 (WikiPathways) ![]() | |
Positive regulation of leukocyte activation | Pathway | GO:0002696 (Other) ![]() | |
SARS-CoV-2 and COVID-19 pathway | Pathway | WP4846 (WikiPathways) ![]() | |
SARS-CoV-2 and ACE2 receptor:
molecular mechanisms and potential therapeutic target | Pathway | WP4883 (WikiPathways) ![]() | |
TMPRSS2 | GeneProduct | 7113 (Entrez Gene) ![]() | |
TNF | GeneProduct | 7124 (Entrez Gene) ![]() | |
Toll-like receptor signaling | Pathway | WP75 (WikiPathways) ![]() |
Annotated Interactions
Source ![]() | Target ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|---|
ACE2 | AGT | mim-modification | 882484 (BioGrid) ![]() | Proteolytic processing |