DNA repair pathways, full network (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none DNA Repair PathwaysMismatch Repair (MMR)Nucleotide Excision Repair (NER)Base Excision Repair (BER)Homologous Recombination Repair (HR)Non-Homologous End Joining (NHEJ)Methyl-Guanine DNA Methyltransferase (MGMT)Fanconi Anemia Pathway (FA)Trans-Lesion Synthesis (TLS)ATMATRAlternative End-Joining (Alt-EJ)RPA1RPA2RPA3RFC1RFC2RFC3RFC4RFC5MSH2MSH3MSH6EXO1PCNAMLH1PMS2POLEPOLE2POLE3POLE4POLD1POLD2POLD3POLD4LIG1RBX1DDB1DDB2CUL4ACUL4BXPCXPARAD23ARAD23BCETN2ERCC1ERCC2ERCC3ERCC4ERCC5ERCC6ERCC8CDK7MNAT1CCNHGTF2H5GTF2H2GTF2H1GTF2H3GTF2H4RPA1RPA2RPA3POLEPOLE2POLE3POLE4POLD1POLD2POLD3POLD4PCNARFC1RFC2RFC3RFC4RFC5LIG1XRCC4XRCC5XRCC6WRNPRKDCDCLRE1CPOLMPOLLLIG4NHEJ1OGG1NTHL1NEIL2NEIL3APEX1APEX2PNKPXRCC1POLBPOLLPARP1PARP2HMGB1LIG1LIG3UNGSMUG1MUTYHMPGMBD4TDGPOLD1POLD2POLD3POLD4PCNAPOLEPOLE2POLE3POLE4FEN1NBNMRE11ARPA1BRCA2RAD50RAD51RAD52RAD54BPOLD1POLD2POLD3POLD4FANCAFANCD2FANCCFANCNFANCMFANCLFANCJFANCIFANCGFANCFFANCEFANCBFAAP24FAAP100MHF1MHF2FAN1USP1UAF1ATRCHEK1H2AXBRCA1BRCA2RAD51CLIG4LIG1XRCC4XRCC5XRCC6PRKDCMRE11RAD50XRS2TERF2RAP1AATMATRREV3LREV1POLHPOLIPOLKPCNAMGMTName: DNA repair pathways, full networkOrganism: Homo sapiens


Description

DNA Repair Pathways (Full Network)

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View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

  1. Decottignies A; ''Alternative end-joining mechanisms: a historical perspective.''; Front Genet, 2013 PubMed Europe PMC Scholia
  2. Kee Y, D'Andrea AD; ''Expanded roles of the Fanconi anemia pathway in preserving genomic stability.''; Genes Dev, 2010 PubMed Europe PMC Scholia
  3. Kciuk M, Bukowski K, Marciniak B, Kontek R; ''Advances in DNA Repair-Emerging Players in the Arena of Eukaryotic DNA Repair.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  4. Goodman MF, Woodgate R; ''Translesion DNA polymerases.''; Cold Spring Harb Perspect Biol, 2013 PubMed Europe PMC Scholia
  5. Klinakis A, Karagiannis D, Rampias T; ''Targeting DNA repair in cancer: current state and novel approaches.''; Cell Mol Life Sci, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117703
Approved
view12:23, 22 May 2021EweitzModified title
112230view17:38, 5 October 2020Khanspersupdated one more literature reference
112229view17:36, 5 October 2020Khanspersupdated literature reference format
112077view14:35, 18 September 2020DeSlAdded PW IDs, changed Unknown Nodes to PWs if ID was given in comment.
112076view14:24, 18 September 2020DeSlChanged arrows to graphical lines.
111386view12:22, 5 August 2020Marvin M2Ontology Term : 'DNA repair pathway' added !
111171view13:43, 21 July 2020EgonwAdded the alternative gene name as comment, as it is not an Ensembl identifier.
111170view13:41, 21 July 2020EgonwReplaced with a human gene: http://www.ensembl.org/Mus_musculus/Gene/Compara_Ortholog/Alignment?db=core;g=ENSMUSG00000031928;g1=ENSG00000020922;hom_id=466173121;r=9:14784654-14837123
111106view20:41, 10 July 2020DiazfloreseModified title
111088view22:36, 7 July 2020DaisydxNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
APEX1GeneProductENSG00000100823 (Ensembl)
APEX2GeneProductENSG00000169188 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
Alternative End-Joining (Alt-EJ)
BRCA1GeneProductENSG00000012048 (Ensembl)
BRCA2GeneProductENSG00000139618 (Ensembl)
Base Excision Repair (BER)PathwayWP4752 (WikiPathways) Wikipathway reference: WP4752
CCNHGeneProductENSG00000134480 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CETN2GeneProductENSG00000147400 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
CUL4AGeneProductENSG00000139842 (Ensembl)
CUL4BGeneProductENSG00000158290 (Ensembl)
DCLRE1CGeneProductENSG00000152457 (Ensembl)
DDB1GeneProductENSG00000167986 (Ensembl)
DDB2GeneProductENSG00000134574 (Ensembl)
DNA Repair PathwaysPathway
ERCC1GeneProductENSG00000012061 (Ensembl)
ERCC2GeneProductENSG00000104884 (Ensembl)
ERCC3GeneProductENSG00000163161 (Ensembl)
ERCC4GeneProductENSG00000175595 (Ensembl)
ERCC5 GeneProductENSG00000134899 (Ensembl)
ERCC6GeneProductENSG00000225830 (Ensembl)
ERCC8GeneProductENSG00000049167 (Ensembl)
EXO1GeneProductENSG00000174371 (Ensembl)
FAAP100GeneProductENSG00000185504 (Ensembl)
FAAP24GeneProductENSG00000131944 (Ensembl)
FAN1GeneProductENSG00000198690 (Ensembl)
FANCAGeneProductENSG00000187741 (Ensembl)
FANCBGeneProductENSG00000181544 (Ensembl)
FANCCGeneProductENSG00000158169 (Ensembl)
FANCD2GeneProductENSG00000144554 (Ensembl)
FANCEGeneProductENSG00000112039 (Ensembl)
FANCFGeneProductENSG00000183161 (Ensembl)
FANCGGeneProductENSG00000221829 (Ensembl)
FANCIGeneProductENSG00000140525 (Ensembl)
FANCJGeneProductENSG00000136492 (Ensembl) BRIP1
FANCLGeneProductENSG00000115392 (Ensembl)
FANCMGeneProductENSG00000187790 (Ensembl)
FANCNGeneProductENSG00000083093 (Ensembl) PALB2
FEN1GeneProductENSG00000168496 (Ensembl)
Fanconi Anemia Pathway (FA)
GTF2H1GeneProductENSG00000110768 (Ensembl)
GTF2H2GeneProductENSG00000145736 (Ensembl)
GTF2H3GeneProductENSG00000111358 (Ensembl)
GTF2H4GeneProductENSG00000213780 (Ensembl)
GTF2H5GeneProductENSG00000272047 (Ensembl)
H2AXGeneProductENSG00000188486 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
Homologous Recombination Repair (HR)PathwayWP186 (WikiPathways) Wikipathway reference: WP186
LIG1GeneProductENSG00000105486 (Ensembl)
LIG3GeneProductENSG00000005156 (Ensembl)
LIG4GeneProductENSG00000174405 (Ensembl)
MBD4GeneProductENSG00000129071 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)
MHF1GeneProductENSG00000175279 (Ensembl) CENPS
MHF2GeneProductENSG00000169689 (Ensembl) CENPX
MLH1GeneProductENSG00000076242 (Ensembl)
MNAT1GeneProductENSG00000020426 (Ensembl)
MPGGeneProductENSG00000103152 (Ensembl)
MRE11AGeneProductENSG00000020922 (Ensembl)
MRE11GeneProductENSG00000020922 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MSH3GeneProductENSG00000113318 (Ensembl)
MSH6GeneProductENSG00000116062 (Ensembl)
MUTYHGeneProductENSG00000132781 (Ensembl)
Methyl-Guanine DNA Methyltransferase (MGMT)
Mismatch Repair (MMR)PathwayWP531 (WikiPathways) Wikipathway reference: WP531
NBNGeneProductENSG00000104320 (Ensembl)
NEIL2GeneProductENSG00000154328 (Ensembl)
NEIL3GeneProductENSG00000109674 (Ensembl)
NHEJ1GeneProductENSG00000187736 (Ensembl)
NTHL1GeneProductENSG00000065057 (Ensembl)
Non-Homologous End Joining (NHEJ)PathwayWP438 (WikiPathways) Wikipathway reference: WP438
Nucleotide Excision Repair (NER)PathwayWP4753 (WikiPathways) Wikipathway reference: WP4753
OGG1GeneProductENSG00000114026 (Ensembl)
PARP1GeneProductENSG00000143799 (Ensembl)
PARP2GeneProductENSG00000129484 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
PMS2GeneProductENSG00000122512 (Ensembl)
PNKPGeneProductENSG00000039650 (Ensembl)
POLBGeneProductENSG00000070501 (Ensembl)
POLD1GeneProductENSG00000062822 (Ensembl)
POLD2GeneProductENSG00000106628 (Ensembl)
POLD3GeneProductENSG00000077514 (Ensembl)
POLD4GeneProductENSG00000175482 (Ensembl)
POLE2GeneProductENSG00000100479 (Ensembl)
POLE3GeneProductENSG00000148229 (Ensembl)
POLE4GeneProductENSG00000115350 (Ensembl)
POLEGeneProductENSG00000177084 (Ensembl)
POLHGeneProductENSG00000170734 (Ensembl)
POLIGeneProductENSG00000101751 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
POLLGeneProductENSG00000166169 (Ensembl)
POLMGeneProductENSG00000122678 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
RAD23AGeneProductENSG00000179262 (Ensembl)
RAD23BGeneProductENSG00000119318 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
RAD51 GeneProductENSG00000051180 (Ensembl)
RAD51CGeneProductENSG00000108384 (Ensembl)
RAD52GeneProductENSG00000002016 (Ensembl)
RAD54BGeneProductENSG00000197275 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
REV1GeneProductENSG00000135945 (Ensembl)
REV3LGeneProductENSG00000009413 (Ensembl)
RFC1GeneProductENSG00000035928 (Ensembl)
RFC2GeneProductENSG00000049541 (Ensembl)
RFC3GeneProductENSG00000133119 (Ensembl)
RFC4GeneProductENSG00000163918 (Ensembl)
RFC5 GeneProductENSG00000111445 (Ensembl)
RPA1GeneProductENSG00000132383 (Ensembl)
RPA2GeneProductENSG00000117748 (Ensembl)
RPA3GeneProductENSG00000106399 (Ensembl)
SMUG1GeneProductENSG00000123415 (Ensembl)
TDGGeneProductENSG00000139372 (Ensembl)
TERF2GeneProductENSG00000132604 (Ensembl)
Trans-Lesion Synthesis (TLS)
UAF1GeneProductENSG00000114742 (Ensembl) WDR48
UNGGeneProductENSG00000076248 (Ensembl)
USP1GeneProductENSG00000162607 (Ensembl)
WRNGeneProductENSG00000165392 (Ensembl)
XPAGeneProductENSG00000136936 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)
XRCC1GeneProductENSG00000073050 (Ensembl)
XRCC4GeneProductENSG00000152422 (Ensembl)
XRCC5GeneProductENSG00000079246 (Ensembl)
XRCC6GeneProductENSG00000196419 (Ensembl)
XRS2GeneProductS. Cerevisiae: YDR369C

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4946"
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