FOXA2 pathway (Homo sapiens)

Description

Role of Foxa2

View approved pathways at the new wikipathways.org.

Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH; ''Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.''; Mol Endocrinol, 2010 PubMed Europe PMC Scholia
Horton JD; ''Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis.''; Biochem Soc Trans, 2002 PubMed Europe PMC Scholia
Wolfrum C, Besser D, Luca E, Stoffel M; ''Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH; ''Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.''; Nat Med, 2008 PubMed Europe PMC Scholia
Wolfrum C, Stoffel M; ''Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion.''; Cell Metab, 2006 PubMed Europe PMC Scholia

View all...

Revision	Action	Time	User	Comment
116631	view	11:19, 9 May 2021	Eweitz	Modified title
116279	view	04:52, 26 April 2021	Khanspers	Ontology Term : 'regulatory pathway' added !
115703	view	08:08, 8 March 2021	Fehrhart	connected unconnected line
115683	view	18:20, 3 March 2021	Egonw	Not a conversion
115625	view	11:45, 2 March 2021	ChesdeWindt	Modified title
115620	view	00:23, 2 March 2021	ChesdeWindt	New pathway

View all...

Name	Type	Database reference
ABCC2	GeneProduct	ENSG00000023839 (Ensembl)
ABCC3	GeneProduct	ENSG00000108846 (Ensembl)
ABCC4	GeneProduct	ENSG00000125257 (Ensembl)
Acetyl-CoA carboxylase 1	Protein	Q13085 (Uniprot-TrEMBL)
Apolipoprotein B-100	Protein	P04114 (Uniprot-TrEMBL)
ChREBP	Protein	Q9NP71 (Uniprot-TrEMBL)
FASN	GeneProduct	ENSG00000169710 (Ensembl)
FOXA1	GeneProduct	ENSG00000129514 (Ensembl)
FOXA2	GeneProduct	ENSG00000125798 (Ensembl)
FOXA2	GeneProduct	ENSG00000125798 (Ensembl)
FOXO1	GeneProduct	ENSG00000150907 (Ensembl)
GSTA1	GeneProduct	ENSG00000243955 (Ensembl)
GSTA2	GeneProduct	ENSG00000244067 (Ensembl)
GSTM2	GeneProduct	ENSG00000213366 (Ensembl)
IRS1	GeneProduct	ENSG00000169047 (Ensembl)
IRS2	GeneProduct	ENSG00000185950 (Ensembl)
Insulin	Protein	A6XGL2 (Uniprot-TrEMBL)
MTTP	GeneProduct	ENSG00000138823 (Ensembl)
PPARGC1B	GeneProduct	ENSG00000155846 (Ensembl)
SLC27A5	GeneProduct	ENSG00000083807 (Ensembl)
SLCO1B1	GeneProduct	ENSG00000134538 (Ensembl)
SREBP-1c	Protein	P36956 (Uniprot-TrEMBL)
TAGs	Metabolite	17855 (ChEBI)