Vasopressin-regulated water reabsorption (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Tight junctionMicrotubuleF-actin depolymerizationNucleusDNAWaterhomeostasisDyneinUrinary lumenBasolateral membraneDynactinRenal interstitiumfluid (blood)Urinary excretionAQP3AQP4DCTN2DCTN4DCTN1DCTN5DCTN6PAQP2AVPRAB11BRAB11APRKACAPRKACBPRKACGGNASARHGDIAARHGDIBARHGDIGWaterRAB5ASTX4cAMPADCY3ADCY6ADCY9CREB3CREB1CREB3L2CREB3L3CREB3L1CREB3L4CREB5DYNC2H1DYNC2LI1DYNLL2DYNLL1DYNC1LI1DYNC1I2DYNC1I1DYNC1LI2DYNC1H1VAMP2NSFPAQP2PAQP2PAQP2WaterAVPR2AQP3AQP2RAB5BRAB5CWaterPAQP2Tight junctionWaterApicalmembraneRecyclingExocytosisEarly endosomeDegradationCollecting duct principal cellName: Vasopressin-regulated water reabsorptionOrganism: Homo sapiens


Description

This pathway describes Vasopressin-regulated water reabsorption from the kidney tubules of the nephrons back into the circulation. Vasopressin, antidiuretic hormone (ADH), is a peptide hormone produced in neurons of the hypothalamus in response to changes in response to extracellular fluid hypertonicity (hyperosmolality), and is secreted into the circulation. When it reaches the kidney, it binds to Vasopressin 2 receptors, triggering an intracellular signaling cascade that ultimately leads to aquaporin 2 (AQP2) vesicles inserted in the apical membrane. This increases the water permeability of the membrane. An osmotic gradient then drives water transport from the collecting duct through AQP2, and water exits the cell on the basolateral side, and back into the circulation.

This description was adapted from [Wikipedia](https://en.wikipedia.org/wiki/Vasopressin) and [KEGG](https://www.genome.jp/entry/pathway+map04962).

This pathway was modeled from [KEGG](https://www.genome.jp/entry/pathway+map04962).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

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  1. Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA; ''Aquaporins in the kidney: from molecules to medicine.''; Physiol Rev, 2002 PubMed Europe PMC Scholia
  2. Boone M, Deen PM; ''Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.''; Pflugers Arch, 2008 PubMed Europe PMC Scholia
  3. Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frøkiaer J, Marples D; ''Physiology and pathophysiology of renal aquaporins.''; J Am Soc Nephrol, 1999 PubMed Europe PMC Scholia
  4. Marples D, Frøkiaer J, Nielsen S; ''Long-term regulation of aquaporins in the kidney.''; Am J Physiol, 1999 PubMed Europe PMC Scholia
  5. Nguyen MK, Nielsen S, Kurtz I; ''Molecular pathogenesis of nephrogenic diabetes insipidus.''; Clin Exp Nephrol, 2003 PubMed Europe PMC Scholia
  6. Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA; ''Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.''; Physiol Genomics, 2008 PubMed Europe PMC Scholia
  7. Deen PM, van Balkom BW, Kamsteeg EJ; ''Routing of the aquaporin-2 water channel in health and disease.''; Eur J Cell Biol, 2000 PubMed Europe PMC Scholia
  8. Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T; ''Localization and trafficking of aquaporin 2 in the kidney.''; Histochem Cell Biol, 2008 PubMed Europe PMC Scholia
  9. Ward DT, Hammond TG, Harris HW; ''Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.''; Annu Rev Physiol, 1999 PubMed Europe PMC Scholia
  10. Fenton RA, Moeller HB; ''Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.''; Prog Brain Res, 2008 PubMed Europe PMC Scholia
  11. Bonilla-Felix M; ''Development of water transport in the collecting duct.''; Am J Physiol Renal Physiol, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139119
Approved
view02:43, 22 May 2025EweitzUse consistent cell width
139118view02:39, 22 May 2025EweitzEconomize layout
139117view02:34, 22 May 2025EweitzEconomize layout
139116view02:23, 22 May 2025EweitzRefine labels for cell type, nucleus
139115view02:18, 22 May 2025EweitzRefine alignments
139114view02:13, 22 May 2025EweitzEconomize layout
139113view02:04, 22 May 2025EweitzEconomize layout
139112view01:56, 22 May 2025EweitzEconomize layout
139111view01:48, 22 May 2025EweitzStack nodes
139110view01:45, 22 May 2025EweitzStack nodes
139109view01:39, 22 May 2025EweitzDecrease node height
139060view04:56, 17 May 2025Khanspersupdate layout
137801view06:30, 8 March 2025EgonwModified description
134585view23:57, 22 July 2024EweitzOntology Term : 'kidney collecting duct principal cell' added !
119785view22:36, 23 August 2021KhanspersModified description
119784view20:49, 23 August 2021Khanspersadded literature references
119783view20:37, 23 August 2021KhanspersOntology Term : 'kidney cell' added !
119782view20:32, 23 August 2021KhanspersOntology Term : 'water transport pathway' added !
119781view20:16, 23 August 2021KhanspersOntology Term : 'vasopressin signaling pathway' added !
119727view15:25, 8 August 2021Khanspersfixed unconnected
119726view15:24, 8 August 2021KhanspersModified description
119725view15:24, 8 August 2021KhanspersModified description
116565view21:56, 7 May 2021Khansperswork in progress
116564view21:40, 7 May 2021Khansperswork in progress
116287view23:16, 27 April 2021KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADCY3GeneProductENSG00000138031 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
AQP2GeneProductENSG00000167580 (Ensembl)
AQP3GeneProductENSG00000165272 (Ensembl)
AQP4GeneProductENSG00000171885 (Ensembl)
ARHGDIAGeneProductENSG00000141522 (Ensembl)
ARHGDIBGeneProductENSG00000111348 (Ensembl)
ARHGDIGGeneProductENSG00000242173 (Ensembl)
AVPGeneProductENSG00000101200 (Ensembl)
AVPR2GeneProductENSG00000126895 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912
CREB3GeneProductENSG00000107175 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913
CREB3L1GeneProductENSG00000157613 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427
CREB3L2GeneProductENSG00000182158 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647
CREB3L3GeneProductENSG00000060566 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677
CREB3L4GeneProductENSG00000143578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284
CREB5GeneProductENSG00000146592 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991
DCTN1GeneProductENSG00000204843 (Ensembl)
DCTN2GeneProductENSG00000175203 (Ensembl)
DCTN4GeneProductENSG00000132912 (Ensembl)
DCTN5GeneProductENSG00000166847 (Ensembl)
DCTN6GeneProductENSG00000104671 (Ensembl)
DYNC1H1GeneProductENSG00000197102 (Ensembl)
DYNC1I1GeneProductENSG00000158560 (Ensembl)
DYNC1I2GeneProductENSG00000077380 (Ensembl)
DYNC1LI1GeneProductENSG00000144635 (Ensembl)
DYNC1LI2GeneProductENSG00000135720 (Ensembl)
DYNC2H1GeneProductENSG00000187240 (Ensembl)
DYNC2LI1GeneProductENSG00000138036 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
NSFGeneProductENSG00000073969 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
RAB11AGeneProductENSG00000103769 (Ensembl)
RAB11BGeneProductENSG00000185236 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
STX4GeneProductENSG00000103496 (Ensembl)
VAMP2GeneProductENSG00000220205 (Ensembl)
WaterMetaboliteHMDB02111 (HMDB)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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