Pleural mesothelioma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none TCF7L1TCF7LEF1TCF7L2CTNNB114-3-3WWTR1TAMsMMChronic inflammation, proliferation, angiogenesis,resistance to apoptosisTumorigenesis & ProliferationLegendLAT1CollagenolysisPI3Ka-cateninVDACAMPKCancer-associated fibroblastsPrognostic markersGene or proteinpolycomb repressive complex 2 (PRC2)IntegrinsJNKsGrowth arrestcytochrome cMEKKMAP3K5MAP3K9MAP3K1MAP3K2MAP3K3MAP3K4MAP3K6ASKMAP3K10MAP3K11MLKIntegrinsMesothelial cellWNT pathwayRTKsTranscriptionDegradationHippo-Merlin signalingStiff and fibronectin rich ECMOther chemokines/cytokinesMAPK pathwayInflammatory cytokines,cellular stressesCell survivalInflammationCell growth,differentiationChemokines, Cytokines,Pro-angiogenic factorsAutophagyChemokines/Cytokines etc.MetastasisAngiogenesisDNA methylationGenetic aberrationsCell survival & growthReplicative immortalityAP-1 dependent genes/Repair genesCadherinsCell growthIncreased protein synthesis+ Cell growthDNA-damageASXL1CTGFKDM6APORCNCa2+AREGBARD1TGFASOSTBTCHCFC1KMT2CFGF2Unfolded protein responseITPR3IGF1IDO1VGLL4CYCSFGF1MCUHGFlet-7WIF1CER1RAFFN1IGF1RPPARGC1ANOTUMglucoseMDM4SERPINF1LIMD1SLC2A1CD44HGFMETLIN28BKITLGHBEGFKITEGFRTCA cycleBRCA1SLC3A2SLC7A5BAG2SPARCCITTNNT1ADAMTS1MAD2L1UHRF1PRSS23KIF23PODXLTRAF2MDKSELECTHRC1DSC3PDGFRAPDGFRBRING1PHC1BMI1RNF2MYCMAXMAD1CCL2TGFB1IL6DKK2DKK4DKK1RASSF1RASSF4RASSF3RASSF2RASSF7RASSF6RASSF5MAPK8MAPK9MAPK10DDIT3ATF3ACTA2ACTA1ACTBACTC1ACTG1ACTG2ITGB1ITGA1ITGA2ITGA3ITGA4ITGAVITGA6ITGB2ITGB3ITGB4CTNNA1CTNNA2CTNNA3VEGFAVEGFBVEGFCVEGFDPLCB4CCND1FOXM1CTGFPD-L1LGALS9CXCL10CXCL5CXCL12TGFB1LAMA1LAMC1LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3RBBP4SUZ12EEDEZH2COL4A1COL4A2COL4A3COL4A4COL4A5COL4A6FGFR1FGFR2FGFR3FGFR4CSF1CCL2IL10CCL4CXCL5CXCL12TGFB1IL34YY1HCFC1CSF2VEGFAVEGFBVEGFCVEGFDCXCL5CXCL1IL6CXCL12CSF3MYCRASTGFB1CXCL12IL6FGF2CDK4CCND1Histone modificationsTP53BCL2MCL1BCLXLCDKN2ABAXBAKRAGECNNE1CDK214-3-3YAPWWTR114-3-3HIF1APIP3MMP9MMP2CDK7PDK1NF2RASGDPNF-KBDNA repairMEK5GRB2TSC1TSC2CUL1ATMSTATSP1STATAP2ROSRNSMAPK14SHCSAV1MST1STK3ERK2LATS1LATS2ATG13ULK1FIP200JAKCDKN1ACell cycleSETD2SETD5SETDB1AngiogenesisULK2HMGB1c-fosMAP2K4MAP2K7E2F1PRB1PDGFVEGFPIGFBTRCKIBRACyclin DGABPAIL-1BFOXO1PUMADR5P21BAXERK1ERK2EIF4c-junNLRP3p16INK4AFAKSRCRHEBMDM2AJUBARPS6KA1RPS6KA5MKNK1MKNK2MNKRPS6KA3RPS6KB1RPS6KB2RSKMAP2K1MAP2K2fra-1TEAD1TEAD2TEAD3TEAD4PIP2CASPASE-1AMOT4E-BPBAP1PTENERK5MAP2K6MAP2K3TERTBECLIN1GTPRASApoptosisp14ARFSOSMKNK1MAPKAPK2MKNK2MNKMKYAPWWTR1MDM2E2F1PRB1HMGB1HMGB1PRAS40TEL2TTI1MLST8DEPTORMTORRPTORHMGB1IL-1BPro IL-1BP21Chemokines, Cytokines,Pro-angiogenic factorsCell survivalWnt signalingAutophagyCell migrationNucleusNF-KBSRCNF2PAK1PAK2PAK3PAK4PAK5PAK6MAPK signaling pathwayMicroenvironment interactionsAngiogenesisPDGFAPDGFBPDGFCPDGFDMMP2MMP3MMP9MMP14EGFIGF2METLamininsFN1COL4A1COL4A2COL4A3COL4A4COL4A5COL4A6LAMA1LAMC1LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3glucoseArginineArginineTryptophanTryptophanKynurenineTumor-associated macrophagesPhagocytosisT-LymphocytesPD-L1ROSIL10prostaglandin E2Myeloid-Derived Suppressor CellsCDH5CDH1CDH10CDH17CDH9CDH16CDH6CDH13CDH20CDH2CDH19CDH22CDH8CDH24CDH18CDH12CDH7CDH15CDH11CDH3CDH4PRKAB2PRKAB1PRKAA2PRKAG1PRKAA1PRKAG2PRKAG3FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKFLT3NTRK1NTRK2MOB1AMOB1BEFNA1FGF1FGF11FGF10EFNA2EGFFGF12CSF1ANGPT4ANGPT2ANGPT1VEGFAEFNA3EFNA4EFNA5FGF14FGF5FGF19FGF17FGF18FGF2FGF3FGF4FGF6FGF7FGF8FGF9VEGFDHGFIGF1IGF2INSKITLGFLT3LGVEGFCVEGFBPDGFBPGFPDGFANGFPDGFCFGF21FGF23FGF22PDGFDFGF20FGF13FGF19NTF3NTF4BDNFTGFAGrowth FactorVEGFAVEGFBVEGFCVEGFDCCL5CD47ITGB1ITGA1ITGA2ITGA3ITGA4ITGAVITGA6B1-integrinMAPK8MAPK9MAPK10JNKsMINK1TNIKMAP4K1MAP4K2MAP4K4MAP4K3PSTK38LNDRG1FZD3FZD8FZD10FZD7FZD4FZD1FZD6FZD5FZD9FZD2SFRP1SFRP2SFRP4SFRP5Frizzled LigandsWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16ROR1RYKROR2LRP5LRP6KREMEN1FRAT1FRAT2GSK3BAPCAXIN1CSNK2BCSNK2A1CSNK2A3CSNK2A2CSNK1ECTNNB1CSNK1A1CSNK1A1LPPPCTNNB1CXXC4SENP2DVL3DVL2DVL126S Proteasome DegradationPUbPPCTNNB1CHD8SOX17CTBP1CTBP2PLAUCCND1JUNCCND3FOSL1MYCCCND2PIK3CAPIK3CBPIK3CDPIK3CGRPS6KB1RPS6KB2EIF4BRPS6AKT1AKT3AKT2PI3K-Akt signaling pathwayJAK/STAT pathwayp38MEF2DATF2STAT1CREB1RPS6KA5ELK1MAXHMGN1DDIT3MYCMAPKAPK2PRAS40TEL2TTI1MLST8DEPTORMTORRPTORFrequently mutated tumor suppressor geneFrequently mutated oncogeneMetabolitePathwayCa2+Endoplasmic reticulumCa2+CYCSpolycomb repressive complex 1 (PRC1)BARD1BRCA1OGTHCFC1GluconeogenesisName: Pleural mesotheliomaOrganism: Homo sapiens


Description

Pleural mesothelioma (PM) is a rare type of cancer affecting the mesothelial cells of the lungs. 80% of the patients have been exposed to asbestos before being diagnosed, but only 5% of the people exposed to asbestos develop mesothelioma.

Through a literature study and community workshop, several pathways have been identified to contribute to the development of the disease, which are captured in this PM pathway. Frequently mutated genes are highlighted in bold, where red nodes indicate tumor suppressor genes, and yellow indicates oncogenes.

This pathway has been published in Frontiers in Oncology: https://doi.org/10.3389/fonc.2022.849640

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Quality Tags

Image:Wplogo_31.pngCommunity: Rare Diseases
Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
137400
Approved
view23:37, 1 March 2025EweitzModified description
137399view23:37, 1 March 2025EweitzOntology Term : 'malignant pleural mesothelioma' added !
137398view23:35, 1 March 2025EweitzOntology Term : 'mesothelial cell' added !
127398
RARE
view20:36, 29 September 2023Khanspersupdated phospho sites
126829view09:08, 26 June 2023Marvin M2Modified description
126828view09:06, 26 June 2023Marvin M2Modified title
125314view21:41, 31 January 2023LarsgwAdd DOI to reference
124802view21:26, 11 December 2022AlexanderPicofixed citations
124785view06:42, 11 December 2022AlexanderPicofixed citations
122659view07:29, 27 April 2022Marvin M2Modified description
120373view20:34, 29 November 2021Marvin M2Connected line
120370view20:20, 29 November 2021Marvin M2Added comments for BAP1
120368view19:57, 29 November 2021Marvin M2Updated BAP1 section
120228view22:12, 15 November 2021Marvin M2Corrected PRC2 interactions
120227view22:05, 15 November 2021Marvin M2minor updates to BAP1 section
120212view21:31, 10 November 2021Marvin M2changed mutated genes view
120211view20:50, 10 November 2021Marvin M2Added HGNC symbols and ensembl IDs
120200view23:19, 8 November 2021ZiskaUpdated Ensembl IDs
120068view18:03, 26 October 2021Marvin M2Reshaped BAP1 section
119947view20:02, 27 September 2021Marvin M2Added list of biomarkers of prognosis
119931view20:20, 22 September 2021Marvin M2Legend added
119827view17:04, 29 August 2021Marvin M2Corrected mutated genes
119809view16:45, 26 August 2021Marvin M2Modified description
119808view15:53, 26 August 2021Marvin M2Added more detail and frequently mutated genes
119807view13:14, 26 August 2021Marvin M2Added MAPK target genes
119806view12:32, 26 August 2021Marvin M2Worked on MAPK pathway
119805view21:15, 25 August 2021Marvin M2Improved top left section
119804view20:04, 25 August 2021Marvin M2Improved, added frequently mutated genes.
119739view08:05, 11 August 2021L DupuisConnected lines
119730view12:29, 10 August 2021ZiskaExtended Wnt pathway
119729view19:44, 9 August 2021ZiskaAdded phosphorylation steps in Hippo signaling
119680view18:06, 28 July 2021EgonwFixed a reference
119679view18:04, 28 July 2021EgonwReplaced secondary ChEBI identifiers with primary ones.
119668view12:40, 28 July 2021Marvin M2Added JNKs
119667view12:22, 28 July 2021Marvin M2Cleaning hippo part
119666view12:11, 28 July 2021Marvin M2Improved hippo pathway part
119659view10:58, 28 July 2021Marvin M2Added content in microenvironment
119654view09:58, 28 July 2021Marvin M2Made space and added microenvironment parts
119642view00:10, 28 July 2021ZiskaExtended Hippo-Merlin signalling
119641view20:58, 27 July 2021Marvin M2Added secretions by mesothelioma
119640view20:12, 27 July 2021Marvin M2Added ECM content, and MMP regulations
119630view20:52, 23 July 2021Marvin M2Added ECM-linked hippo signaling, pathway nodes, and started miroenvironment interactions
119629view13:16, 23 July 2021ZiskaAdded regulation of TERT
119595view11:31, 21 July 2021Marvin M2improved annotations
119594view11:23, 21 July 2021Marvin M2Labels added
119586view08:54, 21 July 2021Marvin M2Red coloring for tumor suppressor genes
119580view15:41, 20 July 2021Marvin M2Minor graphical updates
119579view15:33, 20 July 2021Marvin M2Modified description
119578view15:25, 20 July 2021Marvin M2Added pathway nodes, histone modifications
119576view15:59, 19 July 2021Marvin M2Pathway nodes added

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
14-3-3ProteinA0A0J9YWE8 (Uniprot-TrEMBL)
26S Proteasome DegradationPathwayWP183 (WikiPathways)
4E-BPGeneProductENSG00000187840 (Ensembl)
ACTA1GeneProductENSG00000143632 (Ensembl)
ACTA2GeneProductENSG00000107796 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTC1GeneProductENSG00000159251 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTG2GeneProductENSG00000163017 (Ensembl)
ADAMTS1GeneProductENSG00000154734 (Ensembl)
AJUBAGeneProductENSG00000129474 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AMOTGeneProductENSG00000126016 (Ensembl)
ANGPT1GeneProductENSG00000154188 (Ensembl)
ANGPT2GeneProductENSG00000091879 (Ensembl)
ANGPT4GeneProductENSG00000101280 (Ensembl)
AP2GeneProductENSG00000170323 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
ASXL1GeneProductENSG00000171456 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATF3GeneProductENSG00000162772 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
AngiogenesisPathwayWP1993 (WikiPathways)
ApoptosisPathwayWP1772 (WikiPathways)
ArginineMetaboliteCHEBI:29016 (ChEBI)
AutophagyPathwayWP4923 (WikiPathways)
BAG2GeneProductENSG00000112208 (Ensembl)
BAKGeneProductENSG00000030110 (Ensembl)
BAP1GeneProductENSG00000163930 (Ensembl)
  • The Cancer Genome Atlas Data Portal entry for BAP1: https://portal.gdc.cancer.gov/genes/ENSG00000163930
  • Onco KnowledgeBase entry for BAP1: https://www.oncokb.org/gene/BAP1
  • neXtProt entry for BAP1: https://www.nextprot.org/entry/NX_Q92560/
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCLXLGeneProductENSG00000171791 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl)
BECLIN1GeneProductENSG00000126581 (Ensembl)
BMI1GeneProductENSG00000168283 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
BTCGeneProductENSG00000174808 (Ensembl)
BTRCGeneProductENSG00000166167 (Ensembl)
CASPASE-1GeneProductENSG00000137752 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CD47GeneProductENSG00000196776 (Ensembl)
CDH10GeneProductENSG00000040731 (Ensembl)
CDH11GeneProductENSG00000140937 (Ensembl)
CDH12GeneProductENSG00000154162 (Ensembl)
CDH13GeneProductENSG00000140945 (Ensembl)
CDH15GeneProductENSG00000129910 (Ensembl)
CDH16GeneProductENSG00000166589 (Ensembl)
CDH17GeneProductENSG00000079112 (Ensembl)
CDH18GeneProductENSG00000145526 (Ensembl)
CDH19GeneProductENSG00000071991 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDH20GeneProductENSG00000101542 (Ensembl)
CDH22GeneProductENSG00000149654 (Ensembl)
CDH24GeneProductENSG00000139880 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CDH3GeneProductENSG00000062038 (Ensembl)
CDH4GeneProductENSG00000179242 (Ensembl)
CDH5GeneProductENSG00000179776 (Ensembl)
CDH6GeneProductENSG00000113361 (Ensembl)
CDH7GeneProductENSG00000081138 (Ensembl)
CDH8GeneProductENSG00000150394 (Ensembl)
CDH9GeneProductENSG00000113100 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl) P21
CDKN2AGeneProductENSG00000147889 (Ensembl)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CITGeneProductENSG00000122966 (Ensembl)
CNNE1GeneProductENSG00000105173 (Ensembl)
COL4A1GeneProductENSG00000187498 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProductENSG00000081052 (Ensembl)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProductENSG00000197565 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProductENSG00000213923 (Ensembl)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
CTHRC1GeneProductENSG00000164932 (Ensembl)
CTNNA1GeneProductENSG00000044115 (Ensembl)
CTNNA2GeneProductENSG00000066032 (Ensembl)
CTNNA3GeneProductENSG00000183230 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CUL1GeneProductENSG00000055130 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL5GeneProductENSG00000163735 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl) Cytochrome C
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cell cyclePathwayWP179 (WikiPathways)
Cell migrationPathwayWP4561 (WikiPathways)
Cyclin DGeneProductENSG00000110092 (Ensembl)
DDIT3GeneProductENSG00000175197 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DNA repairPathwayWP4946 (WikiPathways)
DR5GeneProductENSG00000196363 (Ensembl)
DSC3GeneProductENSG00000134762 (Ensembl)
DVL1GeneProductENSG00000107404 (Ensembl)
DVL2GeneProductENSG00000004975 (Ensembl)
DVL3GeneProductENSG00000161202 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EFNA1GeneProductENSG00000169242 (Ensembl)
EFNA2GeneProductENSG00000099617 (Ensembl)
EFNA3GeneProductENSG00000143590 (Ensembl)
EFNA4GeneProductENSG00000243364 (Ensembl)
EFNA5GeneProductENSG00000184349 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4BGeneProductENSG00000063046 (Ensembl)
EIF4GeneProductENSG00000114867 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
ERK5GeneProductENSG00000166484 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FGF10GeneProductENSG00000070193 (Ensembl)
FGF11GeneProductENSG00000161958 (Ensembl)
FGF12GeneProductENSG00000114279 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FGF14GeneProductENSG00000102466 (Ensembl)
FGF17GeneProductENSG00000158815 (Ensembl)
FGF18GeneProductENSG00000156427 (Ensembl)
FGF19GeneProductENSG00000162344 (Ensembl)
FGF1GeneProductENSG00000113578 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF21GeneProductENSG00000105550 (Ensembl)
FGF22GeneProductENSG00000070388 (Ensembl)
FGF23GeneProductENSG00000118972 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl)
FGF3GeneProductENSG00000186895 (Ensembl)
FGF4GeneProductENSG00000075388 (Ensembl)
FGF5GeneProductENSG00000138675 (Ensembl)
FGF6GeneProductENSG00000111241 (Ensembl)
FGF7GeneProductENSG00000140285 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FGF9GeneProductENSG00000102678 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FLT3LGGeneProductENSG00000090554 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
FOSL1GeneProductENSG00000175592 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FRAT1GeneProductENSG00000165879 (Ensembl)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProductENSG00000111432 (Ensembl)
FZD1GeneProductENSG00000157240 (Ensembl)
FZD2GeneProductENSG00000180340 (Ensembl)
FZD3GeneProductENSG00000104290 (Ensembl)
FZD4GeneProductENSG00000106483 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD6GeneProductENSG00000164930 (Ensembl)
FZD7GeneProductENSG00000155760 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
FZD9GeneProductENSG00000188763 (Ensembl)
GABPAGeneProductENSG00000154727 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GluconeogenesisPathwayWP534 (WikiPathways)
HBEGFGeneProductENSG00000113070 (Ensembl)
HCFC1GeneProductENSG00000172534 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
HMGN1GeneProductENSG00000205581 (Ensembl)
Histone modificationsPathwayWP2369 (WikiPathways)
IDO1GeneProductENSG00000131203 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IGF2GeneProductENSG00000167244 (Ensembl)
IL-1BGeneProductENSG00000125538 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL34GeneProductENSG00000157368 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
INSGeneProductENSG00000254647 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITGB4GeneProductENSG00000132470 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JAK/STAT pathwayPathwayWP2593 (WikiPathways)
JAKGeneProductENSG00000162434 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KDM6AGeneProductENSG00000147050 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
KIBRAGeneProductENSG00000113645 (Ensembl)
KIF23GeneProductENSG00000137807 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KITLGGeneProductENSG00000049130 (Ensembl)
KMT2CGeneProductENSG00000055609 (Ensembl)
KREMEN1GeneProductENSG00000183762 (Ensembl)
KynurenineMetaboliteCHEBI:28683 (ChEBI)
LAMA1GeneProductENSG00000101680 (Ensembl)
LAMA2GeneProductENSG00000196569 (Ensembl)
LAMA3GeneProductENSG00000053747 (Ensembl)
LAMA4GeneProductENSG00000112769 (Ensembl)
LAMA5GeneProductENSG00000130702 (Ensembl)
LAMB1GeneProductENSG00000091136 (Ensembl)
LAMB2GeneProductENSG00000172037 (Ensembl)
LAMB3GeneProductENSG00000196878 (Ensembl)
LAMC1GeneProductENSG00000135862 (Ensembl)
LAMC2GeneProductENSG00000058085 (Ensembl)
LAMC3GeneProductENSG00000050555 (Ensembl)
LATS1GeneProductENSG00000131023 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
LGALS9GeneProductENSG00000168961 (Ensembl)
LIMD1GeneProductENSG00000144791 (Ensembl)
LIN28BGeneProductENSG00000187772 (Ensembl)
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
MAD1GeneProductENSG00000002822 (Ensembl)
MAD2L1GeneProductENSG00000164109 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAP3K10GeneProductENSG00000130758 (Ensembl)
MAP3K11GeneProductENSG00000173327 (Ensembl)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K2GeneProductENSG00000169967 (Ensembl)
MAP3K3GeneProductENSG00000198909 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAP3K6GeneProductENSG00000142733 (Ensembl)
MAP3K9GeneProductENSG00000006432 (Ensembl)
MAP4K1GeneProductENSG00000104814 (Ensembl)
MAP4K2GeneProductENSG00000168067 (Ensembl)
MAP4K3GeneProductENSG00000011566 (Ensembl)
MAP4K4GeneProductENSG00000071054 (Ensembl)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAPKAPK2GeneProductENSG00000162889 (Ensembl)
MAXGeneProductENSG00000125952 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MCUGeneProductENSG00000156026 (Ensembl)
MDKGeneProductENSG00000110492 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MDM4GeneProductENSG00000198625 (Ensembl)
MEF2DGeneProductENSG00000116604 (Ensembl)
MEK5GeneProductENSG00000137764 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MINK1GeneProductENSG00000141503 (Ensembl)
MKNK1GeneProductENSG00000079277 (Ensembl)
MKNK2GeneProductENSG00000099875 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MMP14GeneProductENSG00000157227 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MOB1AGeneProductENSG00000114978 (Ensembl)
MOB1BGeneProductENSG00000173542 (Ensembl)
MST1GeneProductENSG00000173531 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NDRG1GeneProductENSG00000104419 (Ensembl) NDR1/2
NF-KBGeneProductENSG00000109320 (Ensembl)
NF2GeneProductENSG00000186575 (Ensembl)
NGFGeneProductENSG00000134259 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
NTF3GeneProductENSG00000185652 (Ensembl)
NTF4GeneProductENSG00000225950 (Ensembl)
NTRK1GeneProductENSG00000198400 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
OGTGeneProductENSG00000147162 (Ensembl)
P21GeneProductENSG00000124762 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PAK2GeneProductENSG00000180370 (Ensembl)
PAK3GeneProductENSG00000077264 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAK5GeneProductENSG00000101349 (Ensembl)
PAK6GeneProductENSG00000137843 (Ensembl)
PD-L1GeneProductENSG00000120217 (Ensembl)
PDGFAGeneProductENSG00000197461 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFCGeneProductENSG00000145431 (Ensembl)
PDGFDGeneProductENSG00000170962 (Ensembl)
PDGFGeneProductENSG00000197461 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PGFGeneProductENSG00000119630 (Ensembl)
PHC1GeneProductENSG00000111752 (Ensembl)
PI3K-Akt signaling pathwayPathwayWP4172 (WikiPathways)
PIGFGeneProductENSG00000151665 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLAUGeneProductENSG00000122861 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PODXLGeneProductENSG00000128567 (Ensembl)
PORCNGeneProductENSG00000102312 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRB1GeneProductENSG00000251655 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRSS23GeneProductENSG00000150687 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PUMAGeneProductENSG00000105327 (Ensembl)
Pro IL-1BGeneProductENSG00000125538 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAGEGeneProductENSG00000204305 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RASSF1GeneProductENSG00000068028 (Ensembl)
RASSF2GeneProductENSG00000101265 (Ensembl)
RASSF3GeneProductENSG00000153179 (Ensembl)
RASSF4GeneProductENSG00000107551 (Ensembl)
RASSF5GeneProductENSG00000266094 (Ensembl)
RASSF6GeneProductENSG00000169435 (Ensembl)
RASSF7GeneProductENSG00000099849 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RING1GeneProductENSG00000204227 (Ensembl)
RNF2GeneProductENSG00000121481 (Ensembl)
RNSMetaboliteQ225595 (Wikidata)
ROR1GeneProductENSG00000185483 (Ensembl)
ROR2GeneProductENSG00000169071 (Ensembl)
ROSMetaboliteCHEBI:70982 (ChEBI)
RPS6GeneProductENSG00000137154 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KA3GeneProductENSG00000177189 (Ensembl)
RPS6KA5GeneProductENSG00000100784 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RYKGeneProductENSG00000163785 (Ensembl)
SAV1GeneProductENSG00000151748 (Ensembl)
SELEGeneProductENSG00000007908 (Ensembl)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SETD5GeneProductENSG00000168137 (Ensembl)
SETDB1GeneProductENSG00000143379 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SPARCGeneProductENSG00000113140 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STATGeneProductENSG00000115415 (Ensembl)
STK38LGeneProductENSG00000211455 (Ensembl) NDR1/2
STK3GeneProductENSG00000104375 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
TCA cyclePathwayWP78 (WikiPathways) Also known as Krebs or citric acid cycle
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TERTGeneProductENSG00000164362 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNIKGeneProductENSG00000154310 (Ensembl)
TNNT1GeneProductENSG00000105048 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
TryptophanMetaboliteCHEBI:16828 (ChEBI)
UHRF1GeneProductENSG00000276043 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
Unfolded

protein

response		PathwayWP4925 (WikiPathways)
VEGFAGeneProductENSG00000112715 (Ensembl)
VEGFBGeneProductENSG00000173511 (Ensembl)
VEGFCGeneProductENSG00000150630 (Ensembl)
VEGFDGeneProductENSG00000165197 (Ensembl)
VEGFGeneProductENSG00000112715 (Ensembl)
VGLL4GeneProductENSG00000144560 (Ensembl)
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProductENSG00000135925 (Ensembl)
WNT10BGeneProductENSG00000169884 (Ensembl)
WNT11GeneProductENSG00000085741 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
WNT1GeneProductENSG00000125084 (Ensembl)
WNT2BGeneProductENSG00000134245 (Ensembl)
WNT2GeneProductENSG00000105989 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT3GeneProductENSG00000108379 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT5AGeneProductENSG00000114251 (Ensembl)
WNT5BGeneProductENSG00000111186 (Ensembl)
WNT6GeneProductENSG00000115596 (Ensembl)
WNT7AGeneProductENSG00000154764 (Ensembl)
WNT7BGeneProductENSG00000188064 (Ensembl)
WWTR1GeneProductENSG00000018408 (Ensembl)
Wnt signalingPathwayWP428 (WikiPathways)
YAPGeneProductENSG00000137693 (Ensembl)
YY1GeneProductENSG00000100811 (Ensembl)
c-fosMetaboliteCHEBI:62519 (ChEBI)
c-junGeneProductENSG00000177606 (Ensembl)
fra-1 GeneProductENSG00000175592 (Ensembl)
glucoseMetaboliteCHEBI:17234 (ChEBI)
let-7RnaENSG00000284520 (Ensembl)
p14ARFProteinQ8N726 (Uniprot-TrEMBL)
p16INK4AGeneProductP42771 (Uniprot-TrEMBL)
prostaglandin E2MetaboliteCHEBI:15551 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5087"
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