Arsenic liver toxicity pathway (Homo sapiens)
From WikiPathways
Description
This is an adverse outcome pathway of arsenic toxicity on liver including key processes leading to arsenic induced liver cancer.
Quality Tags
Ontology Terms
Bibliography
- Angrish MM, Allard P, McCullough SD, Druwe IL, Helbling Chadwick L, Hines E, Chorley BN; ''Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation.''; Environ Health Perspect, 2018 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
Arsenic carcinogenesis - reactive oxygen species | Pathway | WP5233 (WikiPathways) | |
Cell cycle | Pathway | WP179 (WikiPathways) | |
DNA damage response | Pathway | WP707 (WikiPathways) | |
KE1194: Increased DNA damage | Key Event | 1194 (AOP-Wiki KE) | |
KE1395: Liver cancer | Key Event | 1395 (AOP-Wiki KE) | |
KE1487:Binding, Thiol/seleno-proteins involved in protection against oxidative stress | Key Event | 1487 (AOP-Wiki KE) | |
KE155: Inadequate DNA repair | Key Event | 155 (AOP-Wiki KE) | |
KE1894: Chronic low grade systemic inflammation | Key Event | 1894 (AOP-Wiki KE) | |
KE1940: Up-regulation of reactive oxygen species | Key Event | 1940 (AOP-Wiki KE) | |
KE1969: Increased oxidative stress | Key Event | 1969 (AOP-Wiki KE) | |
KE716: Increase, cell proliferation (hepatocytes) | Key Event | 716 (AOP-Wiki KE) | |
NRF2 pathway | Pathway | WP2884 (WikiPathways) | |
Oxidative damage response | Pathway | WP3941 (WikiPathways) | |
TNF-alpha signaling pathway | Pathway | WP231 (WikiPathways) |
Annotated Interactions
No annotated interactions